1 to 9 of 9 literature results

• Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.

  Phosphoinositide 3-kinases (PI3Ks) signal downstream of multiple cell-surface receptor types. Class IA PI3K isoforms couple to tyrosine kinases and co…

  Authors: Mariona Graupera, Julie Guillermet-Guibert, Lazaros C Foukas, Li-Kun Phng, Robert J Cain, Ashreena Salpekar, Wayne Pearce, Stephen Meek, Jaime Millan, Pedro R Cutillas,…

  Source: Nature. 2008 May 29

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• Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation.

  The eight catalytic subunits of the mammalian phosphoinositide-3-OH kinase (PI(3)K) family form the backbone of an evolutionarily conserved signalling…

  Authors: Lazaros C Foukas, Marc Claret, Wayne Pearce, Klaus Okkenhaug, Stephen Meek, Emma Peskett, Sara Sancho, Andrew J H Smith, Dominic J Withers, Bart Vanhaesebroeck

  Source: Nature. 2006 May 18

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• Essential role for the p110delta phosphoinositide 3-kinase in the allergic response.

  Inflammatory substances released by mast cells induce and maintain the allergic response. Mast cell differentiation and activation are regulated, resp…

  Authors: Khaled Ali, Antonio Bilancio, Matthew Thomas, Wayne Pearce, Alasdair M Gilfillan, Christine Tkaczyk, Nicolas Kuehn, Alexander Gray, June Giddings, Emma Peskett,…

  Source: Nature. 2004 Oct 21

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• Inactivation of PI3Kgamma and PI3Kdelta distorts T-cell development and causes multiple organ inflammation.

  Mice lacking both the p110gamma and p110delta isoforms display severe impairment of thymocyte development. Here, we show that this phenotype is recapi…

  Authors: Hong Ji, Felix Rintelen, Caroline Waltzinger, Dominique Bertschy Meier, Antonio Bilancio, Wayne Pearce, Emilio Hirsch, Matthias P Wymann, Thomas Rückle, Montserrat Camps,…

  Source: Blood. 2007 Oct 15

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• Airway inflammation: chemokine-induced neutrophilia and the class I phosphoinositide 3-kinases.

  Class I phosphoinositide 3-kinases (PI3K) are known to play a significant role in neutrophil chemotaxis. However, the relative contributions of differ…

  Authors: Matthew J Thomas, Alexandra Smith, Denise H Head, Laura Milne, Andrew Nicholls, Wayne Pearce, Bart Vanhaesebroeck, Matthias P Wymann, Emilio Hirsch, Alexandre Trifilieff,…

  Source: European journal of immunology. 2005 Apr

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• Role of the p110delta PI 3-kinase in integrin and ITAM receptor signalling in platelets.

  We have investigated the function of the p110delta catalytic subunit of phosphoinositide 3-kinase (PI 3-kinase) in platelets using p110delta knock-out…

  Authors: Yotis A Senis, Ben T Atkinson, Andrew C Pearce, Peter Wonerow, Jocelyn M Auger, Klaus Okkenhaug, Wayne Pearce, Elena Vigorito, Bart Vanhaesebroeck, Martin Turner,…

  Source: Platelets. 2005 May-Jun

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• Ultrasensitive and absolute quantification of the phosphoinositide 3-kinase/Akt signal transduction pathway by mass spectrometry.

  The phosphoinositide 3-kinase (PI3K)/Akt pathway controls a vast array of normal physiological processes and is frequently aberrantly activated in can…

  Authors: Pedro R Cutillas, Asim Khwaja, Mariona Graupera, Wayne Pearce, Severine Gharbi, Mike Waterfield, Bart Vanhaesebroeck

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2006 Jun 13

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• Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase.

  The expression and function of the 8 distinct catalytic isoforms of PI 3-kinase (PI3K) in the nervous system are unknown. Whereas most PI3Ks have a br…

  Authors: Britta J Eickholt, Aminul I Ahmed, Meirion Davies, Evangelia A Papakonstanti, Wayne Pearce, Michelle L Starkey, Antonio Bilancio, Anna C Need, Andrew J H Smith, Susan M Hall,…

  Source: PloS one. 2007

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• Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice.

  Class IA phosphoinositide 3-kinases (PI3Ks) are a family of p85/p110 heterodimeric lipid kinases that generate second messenger signals downstream of …

  Authors: Klaus Okkenhaug, Antonio Bilancio, Géraldine Farjot, Helen Priddle, Sara Sancho, Emma Peskett, Wayne Pearce, Stephen E Meek, Ashreena Salpekar, Michael D Waterfield,…

  Source: Science (New York, N.Y.). 2002 Aug 9

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