1 to 10 of 1,075 literature results

• The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation.

  Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pleiotropic cytokine that controls the production and function of blood cells, is dereg…

  Authors: Guido Hansen, Timothy R Hercus, Barbara J McClure, Frank C Stomski, Mara Dottore, Jason Powell, Hayley Ramshaw, Joanna M Woodcock, Yibin Xu, Mark Guthridge,…

  Source: Cell. 2008 Aug 8

  View Full Text

• The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease.

  Already 20 years have passed since the cloning of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor alpha-chain, the first member…

  Authors: Timothy R Hercus, Daniel Thomas, Mark A Guthridge, Paul G Ekert, Jack King-Scott, Michael W Parker, Angel F Lopez

  Source: Blood. 2009 Aug 13

  View Full Text

• The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants.

  The commonly used anti-cancer drug chlorambucil is the primary treatment for patients with chronic lymphocytic leukaemia. Chlorambucil has been shown …

  Authors: Lorien J Parker, Sarah Ciccone, Louis C Italiano, Alessandra Primavera, Aaron J Oakley, Craig J Morton, Nancy C Hancock, Mario Lo Bello, Michael W Parker

  Source: Journal of molecular biology. 2008 Jun 27

  View Full Text

• Oseltamivir resistance and the H274Y neuraminidase mutation in seasonal, pandemic and highly pathogenic influenza viruses.

  Along with influenza vaccines, the world is currently almost completely dependent on two licensed drugs for the treatment or prevention of seasonal (i…

  Authors: Aeron C Hurt, Jessica K Holien, Michael W Parker, Ian G Barr

  Source: Drugs. 2009

  View Full Text

• Prediction of sublayer depth in turbid media using spatially offset Raman spectroscopy.

  We demonstrate experimentally the feasibility of monitoring the depth of optically thick layers within turbid media using spatially offset Raman spect…

  Authors: N A Macleod, A Goodship, A W Parker, P Matousek

  Source: Analytical chemistry. 2008 Nov 1

  View Full Text

• Technique for enhancing signal in conventional backscattering fluorescence and Raman spectroscopy of turbid media.

  We demonstrate experimentally, for the first time, the feasibility of passively enhancing fluorescence and Raman signals from diffusely scattering med…

  Authors: Kevin Buckley, Allen Goodship, Neil A Macleod, Anthony W Parker, Pavel Matousek

  Source: Analytical chemistry. 2008 Aug 1

  View Full Text

• Anxiety over GABA(A) receptor structure relieved by AChBP.

  The GABA(A) receptor is the primary mediator of inhibitory neurotransmission in the brain and is a major target for neuromodulatory drugs such as benz…

  Authors: Brett A Cromer, Craig J Morton, Michael W Parker

  Source: Trends in biochemical sciences. 2002 Jun

  View Full Text

• Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site.

  HIV integrase (IN) is an essential enzyme in HIV replication and an important target for drug design. IN has been shown to interact with a number of c…

  Authors: Jerome Wielens, Stephen J Headey, Dharshini Jeevarajah, David I Rhodes, John Deadman, David K Chalmers, Martin J Scanlon, Michael W Parker

  Source: FEBS letters. 2010 Mar 15

  View Full Text

• A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore.

  Picrotoxin, an antagonist of structurally-rated GABA(A) receptors (GABA(A)Rs) and glycine receptors (GlyRs), is an equimolar mixture of picrotoxinin (…

  Authors: Zhe Yang, Brett A Cromer, Robert J Harvey, Michael W Parker, Joseph W Lynch

  Source: Journal of neurochemistry. 2007 Oct

  View Full Text

• Structures of perfringolysin O suggest a pathway for activation of cholesterol-dependent cytolysins.

  Cholesterol-dependent cytolysins (CDCs), a large family of bacterial toxins, are secreted as water-soluble monomers and yet are capable of generating …

  Authors: Jamie Rossjohn, Galina Polekhina, Susanne C Feil, Craig J Morton, Rodney K Tweten, Michael W Parker

  Source: Journal of molecular biology. 2007 Apr 13

  View Full Text