1 to 10 of 19 literature results

• Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.

  Adipocyte fatty-acid-binding protein, aP2 (FABP4) is expressed in adipocytes and macrophages, and integrates inflammatory and metabolic responses. Stu…

  Authors: Masato Furuhashi, Gürol Tuncman, Cem Z Görgün, Liza Makowski, Genichi Atsumi, Eric Vaillancourt, Keita Kono, Vladimir R Babaev, Sergio Fazio, MacRae F Linton,…

  Source: Nature. 2007 Jun 21

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• Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.

  BACKGROUND: The peroxisome proliferator-activated receptor-alpha (PPARalpha) plays important roles in lipid metabolism, inflammation, and atherosclero…

  Authors: Vladimir R Babaev, Hiroyuki Ishiguro, Lei Ding, Patricia G Yancey, Dwayne E Dove, William J Kovacs, Clay F Semenkovich, Sergio Fazio, MacRae F Linton

  Source: Circulation. 2007 Sep 18

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• Cyclooxygenase-1 deficiency in bone marrow cells increases early atherosclerosis in apolipoprotein E- and low-density lipoprotein receptor-null mice.

  BACKGROUND: Cyclooxygenase-1 (COX-1) has been implicated in the pathogenesis of atherothrombosis and is expressed by the major cell types of atheroscl…

  Authors: Vladimir R Babaev, Lei Ding, Jeff Reese, Jason D Morrow, Matthew D Breyer, Sudhansu K Dey, Sergio Fazio, MacRae F Linton

  Source: Circulation. 2006 Jan 3

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• Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice.

  BACKGROUND: The adipocyte fatty acid-binding protein (FABP) aP2 is expressed by adipocytes and macrophages and modulates insulin resistance, glucose a…

  Authors: Jeffrey B Boord, Kazuhisa Maeda, Liza Makowski, Vladimir R Babaev, Sergio Fazio, MacRae F Linton, Gökhan S Hotamisligil

  Source: Circulation. 2004 Sep 14

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• Absence of regulated splicing of fibronectin EDA exon reduces atherosclerosis in mice.

  Atherosclerotic lesions are characterized by a profound alteration in the architecture of the arterial intima, with a marked increase of fibronectin (…

  Authors: Vladimir R Babaev, Fabiola Porro, MacRae F Linton, Sergio Fazio, Francisco E Baralle, Andrés F Muro

  Source: Atherosclerosis. 2008 Apr

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• Inactivation of macrophage scavenger receptor class B type I promotes atherosclerotic lesion development in apolipoprotein E-deficient mice.

  BACKGROUND: Scavenger receptor class B type I (SR-BI) is expressed in macrophages, where it has been proposed to facilitate cholesterol efflux. Howeve…

  Authors: Wenwu Zhang, Patricia G Yancey, Yan Ru Su, Vladimir R Babaev, Yuomin Zhang, Sergio Fazio, MacRae F Linton

  Source: Circulation. 2003 Nov 4

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• Severely altered cholesterol homeostasis in macrophages lacking apoE and SR-BI.

  Mice deficient in scavenger receptor class B type I (SR-BI) and apolipoprotein E (apoE) [double knockout (DKO) mice] develop dyslipidemia, accelerated…

  Authors: Patricia G Yancey, W Gray Jerome, Hong Yu, Evelyn E Griffin, Brian E Cox, Vladimir R Babaev, Sergio Fazio, MacRae F Linton

  Source: Journal of lipid research. 2007 May

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• Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice.

  BACKGROUND: Atherosclerosis has features of an inflammatory disease. Because cyclooxygenase (COX)-2 is expressed in atherosclerotic lesions and promot…

  Authors: Michael E Burleigh, Vladimir R Babaev, John A Oates, Raymond C Harris, Shiva Gautam, Denis Riendeau, Lawrence J Marnett, Jason D Morrow, Sergio Fazio, MacRae F Linton

  Source: Circulation. 2002 Apr 16

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• Transiently heightened angiotensin II has distinct effects on atherosclerosis and aneurysm formation in hyperlipidemic mice.

  Experimentally sustained increase in angiotensin II (AngII) promotes tissue destruction in various cardiovascular disorders. We examined whether trans…

  Authors: Nobuhiko Ayabe, Vladimir R Babaev, Yiwei Tang, Takakuni Tanizawa, Agnes B Fogo, Macrae F Linton, Iekuni Ichikawa, Sergio Fazio, Valentina Kon

  Source: Atherosclerosis. 2006 Feb

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• Cyclooxygenase-2 promotes early atherosclerotic lesion formation in ApoE-deficient and C57BL/6 mice.

  Cyclooxygenase (COX) 2 is expressed in atherosclerotic lesions. We have previously reported that selective inhibition of COX-2 reduces early atheroscl…

  Authors: Michael E Burleigh, Vladimir R Babaev, Patricia G Yancey, Amy S Major, Jennifer L McCaleb, John A Oates, Jason D Morrow, Sergio Fazio, Macrae F Linton

  Source: Journal of molecular and cellular cardiology. 2005 Sep

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