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1 to 10 of 12 literature results
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Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance.
Obesity and insulin resistance, the cardinal features of metabolic syndrome, are closely associated with a state of low-grade inflammation. In adipose…
Authors: Justin I Odegaard, Roberto R Ricardo-Gonzalez, Matthew H Goforth, Christine R Morel, Vidya Subramanian, Lata Mukundan, Alex Red Eagle, Divya Vats, Frank Brombacher, Anthony W Ferrante,…
Source: Nature. 2007 Jun 28
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Effects of photochemically activated alkylating agents of the FR900482 family on chromatin.
Bioreductive alkylating agents are an important class of clinical antitumor antibiotics that crosslink and monoalkylate DNA. Here, we use a synthetic,…
Authors: Vidya Subramanian, Pascal Ducept, Robert M Williams, Karolin Luger
Source: Chemistry & biology. 2007 May
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CGI-58/ABHD5 is a coenzyme A-dependent lysophosphatidic acid acyltransferase.
Mutations in human CGI-58/ABHD5 cause Chanarin-Dorfman syndrome (CDS), characterized by excessive storage of triacylglycerol in tissues. CGI-58 is an …
Authors: Gabriela Montero-Moran, Jorge M Caviglia, Derek McMahon, Alexis Rothenberg, Vidya Subramanian, Zhi Xu, Samuel Lara-Gonzalez, Judith Storch, George M Carman, Dawn L Brasaemle
Source: Journal of lipid research. 2010 Apr
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Perilipin A and the control of triacylglycerol metabolism.
Perilipin A is the most abundant protein associated with the lipid droplets of adipocytes and functions to control both basal and stimulated lipolysis…
Authors: Dawn L Brasaemle, Vidya Subramanian, Anne Garcia, Amy Marcinkiewicz, Alexis Rothenberg
Source: Molecular and cellular biochemistry. 2009 Jun
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Hydrophobic sequences target and anchor perilipin A to lipid droplets.
Perilipins regulate triacylglycerol storage and hydrolysis in adipocytes. The central 25% of the perilipin A sequence, including three hydrophobic seq…
Authors: Vidya Subramanian, Anne Garcia, Anna Sekowski, Dawn L Brasaemle
Source: Journal of lipid research. 2004 Nov
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Obesity, inflammation, and macrophages.
The World Health Organization estimates that since 1980 the prevalence of obesity has increased more than threefold throughout much of the world, and …
Authors: Vidya Subramanian, Anthony W Ferrante
Source: Nestlé Nutrition workshop series. Paediatric programme. 2009
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Methods to characterize the effect of DNA-modifying compounds on nucleosomal DNA.
Eukaryotic DNA forms a complex with an equal mass of proteins to form chromatin. To fully understand the action of DNA-reactive antitumor antibiotics …
Authors: Vidya Subramanian, Robert M Williams, Dale L Boger, Karolin Luger
Source: Methods in molecular biology (Clifton, N.J.). 2010
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Screening for novel regulators of embryonic stem cell identity.
Two recent studies, including one in this issue of Cell Stem Cell, have identified novel regulators of embryonic stem cell (ESC) self-renewal using ge…
Authors: Vidya Subramanian, Carla A Klattenhoff, Laurie A Boyer
Source: Cell stem cell. 2009 May 8
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Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance.
Macrophage infiltration and activation in metabolic tissues underlie obesity-induced insulin resistance and type 2 diabetes. While inflammatory activa…
Authors: Justin I Odegaard, Roberto R Ricardo-Gonzalez, Alex Red Eagle, Divya Vats, Christine R Morel, Matthew H Goforth, Vidya Subramanian, Lata Mukundan, Anthony W Ferrante, Ajay Chawla
Source: Cell metabolism. 2008 Jun
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The central domain is required to target and anchor perilipin A to lipid droplets.
The perilipins are the most abundant proteins coating the surfaces of lipid droplets in adipocytes and are found at lower levels surrounding lipid dro…
Authors: Anne Garcia, Anna Sekowski, Vidya Subramanian, Dawn L Brasaemle
Source: The Journal of biological chemistry. 2003 Jan 3
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