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Endothelial cells form a phalanx to block tumor metastasis.
Tumor blood vessels deliver oxygen poorly, thereby contributing to tumor hypoxia and upregulation of proangiogenic cytokines in an escalating feedback…
Authors: Victoria L Bautch
Source: Cell. 2009 Mar 6
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Local guidance of emerging vessel sprouts requires soluble Flt-1.
Blood vessel networks form via sprouting of endothelial cells from parent vessels. Extrinsic cues guide sprouts after they leave the initiation site, …
Authors: John C Chappell, Sarah M Taylor, Napoleone Ferrara, Victoria L Bautch
Source: Developmental cell. 2009 Sep
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Endocardial cells are a distinct endothelial lineage derived from Flk1+ multipotent cardiovascular progenitors.
Identification of multipotent cardiac progenitors has provided important insights into the mechanisms of myocardial lineage specification, yet has don…
Authors: Andrew M Misfeldt, Scott C Boyle, Kevin L Tompkins, Victoria L Bautch, Patricia A Labosky, H Scott Baldwin
Source: Developmental biology. 2009 Sep 1
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Orientation of endothelial cell division is regulated by VEGF signaling during blood vessel formation.
New blood vessel formation requires the coordination of endothelial cell division and the morphogenetic movements of vessel expansion, but it is not k…
Authors: Gefei Zeng, Sarah M Taylor, Janet R McColm, Nicholas C Kappas, Joseph B Kearney, Lucy H Williams, Mary E Hartnett, Victoria L Bautch
Source: Blood. 2007 Feb 15
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Blood vessel patterning at the embryonic midline.
The reproducible pattern of blood vessels formed in vertebrate embryos has been described extensively, but only recently have we obtained the genetic …
Authors: Kelly A Hogan, Victoria L Bautch
Source: Current topics in developmental biology. 2004
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The VEGF receptor flt-1 (VEGFR-1) is a positive modulator of vascular sprout formation and branching morphogenesis.
Sprouting angiogenesis is critical to blood vessel formation, but the cellular and molecular controls of this process are poorly understood. We used t…
Authors: Joseph B Kearney, Nicholas C Kappas, Catharina Ellerstrom, Frank W DiPaola, Victoria L Bautch
Source: Blood. 2004 Jun 15
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Neutralizing VEGF decreases tortuosity and alters endothelial cell division orientation in arterioles and veins in a rat model of ROP: relevance to plus disease.
PURPOSE: To study the effects of vascular endothelial growth factor (VEGF) on endothelial nitric oxide synthetase (eNOS) and retinal vascular tortuosi…
Authors: M Elizabeth Hartnett, David Martiniuk, Grace Byfield, Pete Geisen, Gefei Zeng, Victoria L Bautch
Source: Investigative ophthalmology & visual science. 2008 Jul
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Assembly and patterning of vertebrate blood vessels.
The mechanisms that regulate blood vessel assembly at appropriate sites in the organism are poorly understood, yet understanding this regulation is cr…
Authors: Victoria L Bautch, Carrie A Ambler
Source: Trends in cardiovascular medicine. 2004 May
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HoxB5 is an upstream transcriptional switch for differentiation of the vascular endothelium from precursor cells.
Endothelial cells differentiate from mesoderm-derived precursors to initiate the earliest events in vascular development. Although the signaling event…
Authors: Yaxu Wu, Martin Moser, Victoria L Bautch, Cam Patterson
Source: Molecular and cellular biology. 2003 Aug
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A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
We identified Ras guanine-releasing protein 3 (RasGRP3) as a guanine exchange factor expressed in blood vessels via an embryonic stem (ES) cell-based …
Authors: David M Roberts, Amanda L Anderson, Michihiro Hidaka, Raymond L Swetenburg, Cam Patterson, William L Stanford, Victoria L Bautch
Source: Molecular and cellular biology. 2004 Dec
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