1 to 8 of 8 literature results

• Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors.

  Inhibitors of alpha(v)beta(3) and alpha(v)beta(5) integrin have entered clinical trials as antiangiogenic agents for cancer treatment but generally ha…

  Authors: Andrew R Reynolds, Ian R Hart, Alan R Watson, Jonathan C Welti, Rita G Silva, Stephen D Robinson, Georges Da Violante, Morgane Gourlaouen, Mishal Salih, Matt C Jones,…

  Source: Nature medicine. 2009 Apr

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• A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1.

  Cell adhesion to extracellular matrix (ECM) proteins is crucial for the structural integrity of tissues and epithelial-mesenchymal interactions mediat…

  Authors: Kogo Takamiya, Vassiliki Kostourou, Susanne Adams, Shalini Jadeja, Georges Chalepakis, Peter J Scambler, Richard L Huganir, Ralf H Adams

  Source: Nature genetics. 2004 Feb

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• Effects of overexpression of dimethylarginine dimethylaminohydrolase on tumor angiogenesis assessed by susceptibility magnetic resonance imaging.

  Intracellular factors that regulate nitric oxide (NO) synthesis represent important targets in tumor progression. Overexpression of dimethylarginine d…

  Authors: Vassiliki Kostourou, Simon P Robinson, Guy St J Whitley, John R Griffiths

  Source: Cancer research. 2003 Aug 15

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• Efficient, inducible Cre-recombinase activation in vascular endothelium.

  In recent years, gene-targeting studies in mice have elucidated many molecular mechanisms in vascular biology. However, it has been difficult to apply…

  Authors: Suzanne Claxton, Vassiliki Kostourou, Shalini Jadeja, Pierre Chambon, Kairbaan Hodivala-Dilke, Marcus Fruttiger

  Source: Genesis (New York, N.Y. : 2000). 2008 Feb

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• Alphav beta3 integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesis.

  Both vascular endothelial growth factor receptors (VEGFR) and integrins are major regulators of VEGF-induced angiogenesis. Previous work has shown tha…

  Authors: Stephen D Robinson, Louise E Reynolds, Vassiliki Kostourou, Andrew R Reynolds, Rita Graça da Silva, Bernardo Tavora, Marianne Baker, John F Marshall, Kairbaan M Hodivala-Dilke

  Source: The Journal of biological chemistry. 2009 Dec 4

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• Genetic ablation of the alpha 6-integrin subunit in Tie1Cre mice enhances tumour angiogenesis.

  Laminins are expressed highly in blood vessel basement membranes and have been implicated in angiogenesis. alpha6beta1- and alpha6beta4-integrins are …

  Authors: Mitchel Germain, Adèle De Arcangelis, Stephen D Robinson, Marianne Baker, Bernardo Tavora, Gabriela D'Amico, Rita Silva, Vassiliki Kostourou, Louise E Reynolds, Alan Watson,…

  Source: The Journal of pathology. 2010 Feb

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• Regulation of lymphatic-blood vessel separation by endothelial Rac1.

  Sprouting angiogenesis and lymphatic-blood vessel segregation both involve the migration of endothelial cells, but the precise migratory molecules tha…

  Authors: Gabriela D'Amico, Dylan T Jones, Emma Nye, Karen Sapienza, Antoine R Ramjuan, Louise E Reynolds, Stephen D Robinson, Vassiliki Kostourou, Dolores Martinez, Deborah Aubyn,…

  Source: Development (Cambridge, England). 2009 Dec

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• Overexpression of dimethylarginine dimethylaminohydrolase enhances tumor hypoxia: an insight into the relationship of hypoxia and angiogenesis in vivo.

  The oxygenation status of tumors derived from wild-type C6 glioma cells and clone D27 cells overexpressing dimethylarginine dimethylaminohydrolase (DD…

  Authors: Vassiliki Kostourou, Helen Troy, Joanne F Murray, Elizabeth R Cullis, Guy St J Whitley, John R Griffiths, Simon P Robinson

  Source: Neoplasia (New York, N.Y.). 2004 Jul-Aug

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