10 literature results

• Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas.

  Although cancer arises from a combination of mutations in oncogenes and tumour suppressor genes, the extent to which tumour suppressor gene loss is re…

  Authors: Wen Xue, Lars Zender, Cornelius Miething, Ross A Dickins, Eva Hernando, Valery Krizhanovsky, Carlos Cordon-Cardo, Scott W Lowe

  Source: Nature. 2007 Feb 8

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• Senescence of activated stellate cells limits liver fibrosis.

  Cellular senescence acts as a potent mechanism of tumor suppression; however, its functional contribution to noncancer pathologies has not been examin…

  Authors: Valery Krizhanovsky, Monica Yon, Ross A Dickins, Stephen Hearn, Janelle Simon, Cornelius Miething, Herman Yee, Lars Zender, Scott W Lowe

  Source: Cell. 2008 Aug 22

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• Stem cells: The promises and perils of p53.

  Authors: Valery Krizhanovsky, Scott W Lowe

  Source: Nature. 2009 Aug 27

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• Tissue-specific and reversible RNA interference in transgenic mice.

  Genetically engineered mice provide powerful tools for understanding mammalian gene function. These models traditionally rely on gene overexpression f…

  Authors: Ross A Dickins, Katherine McJunkin, Eva Hernando, Prem K Premsrirut, Valery Krizhanovsky, Darren J Burgess, Sang Yong Kim, Carlos Cordon-Cardo, Lars Zender, Gregory J Hannon,…

  Source: Nature genetics. 2007 Jul

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• A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation.

  Cellular senescence is a stable state of proliferative arrest that provides a barrier to malignant transformation and contributes to the antitumor act…

  Authors: Masashi Narita, Masako Narita, Valery Krizhanovsky, Sabrina Nuñez, Agustin Chicas, Stephen A Hearn, Michael P Myers, Scott W Lowe

  Source: Cell. 2006 Aug 11

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• A novel role for the choroid plexus in BMP-mediated inhibition of differentiation of cerebellar neural progenitors.

  Cerebellar granule cells, the most abundant neurons in the mammalian brain, arise in the rhombic lip located at the roof of the brain's fourth ventric…

  Authors: Valery Krizhanovsky, Nissim Ben-Arie

  Source: Mechanisms of development. 2006 Jan

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• Genotype identification of Math1/LacZ knockout mice based on real-time PCR with SYBR Green I dye.

  Knockout mice are widely used in all fields of biomedical research. Determining the genotype of every newborn mouse is a tedious task, usually perform…

  Authors: Valery Krizhanovsky, Esther Golenser, Nissim Ben-Arie

  Source: Journal of neuroscience methods. 2004 Jul 30

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• Math1 target genes are enriched with evolutionarily conserved clustered E-box binding sites.

  The basic helix-loop-helix (bHLH) transcription factor Math1 and its orthologs are fundamental for proper development of various neuronal subpopulatio…

  Authors: Valery Krizhanovsky, Lilach Soreq, Vitaly Kliminski, Nissim Ben-Arie

  Source: Journal of molecular neuroscience : MN. 2006

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• Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway.

  Cerebellar granule cells (CGC) are the most abundant neurons in the mammalian brain, and an important tool for unraveling molecular mechanisms underly…

  Authors: Roi Gazit, Valery Krizhanovsky, Nissim Ben-Arie

  Source: Development (Cambridge, England). 2004 Feb

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• Dual control of neurogenesis by PC3 through cell cycle inhibition and induction of Math1.

  Growing evidence indicates that cell cycle arrest and neurogenesis are highly coordinated and interactive processes, governed by cell cycle genes and …

  Authors: Daniela Canzoniere, Stefano Farioli-Vecchioli, Filippo Conti, Maria Teresa Ciotti, Ada Maria Tata, Gabriella Augusti-Tocco, Elisabetta Mattei, Madepalli K Lakshmana, Valery Krizhanovsky, Steven A Reeves,…

  Source: The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 Mar 31

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