10 literature results

• Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint.

  Activation of toll-like receptors (TLRs) leads to derepression and subsequent activation of inflammatory response genes that play essential roles in i…

  Authors: Wendy Huang, Serena Ghisletti, Valentina Perissi, Michael G Rosenfeld, Christopher K Glass

  Source: Molecular cell. 2009 Jul 10

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• TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints.

  A key strategy to achieve regulated gene expression in higher eukaryotes is to prevent illegitimate signal-independent activation by imposing robust c…

  Authors: Valentina Perissi, Claudio Scafoglio, Jie Zhang, Kenneth A Ohgi, David W Rose, Christopher K Glass, Michael G Rosenfeld

  Source: Molecular cell. 2008 Mar 28

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• A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma.

  Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) has essential roles in adipogenesis and glucose homeostasis, and is a molecular target o…

  Authors: Gabriel Pascual, Amy L Fong, Sumito Ogawa, Amir Gamliel, Andrew C Li, Valentina Perissi, David W Rose, Timothy M Willson, Michael G Rosenfeld, Christopher K Glass

  Source: Nature. 2005 Sep 29

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• A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors.

  The mechanisms that control the precisely regulated switch from gene repression to gene activation represent a central question in mammalian developme…

  Authors: Valentina Perissi, Aneel Aggarwal, Christopher K Glass, David W Rose, Michael G Rosenfeld

  Source: Cell. 2004 Feb 20

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• Anti-inflammatory and antidiabetic roles of PPARgamma.

  The peroxisome proliferator-activated receptor gamma (PPARgamma) regulates adipocyte differentiation and glucose homeostasis and is the molecular targ…

  Authors: Gabriel Pascual, Amy L Sullivan, Sumito Ogawa, Amir Gamliel, Valentina Perissi, Michael G Rosenfeld, Christopher K Glass

  Source: Novartis Foundation symposium. 2007

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• Deconstructing repression: evolving models of co-repressor action.

  A crucial aspect of development, homeostasis and prevention of disease is the strict maintenance of patterns of gene repression. Gene repression is la…

  Authors: Valentina Perissi, Kristen Jepsen, Christopher K Glass, Michael G Rosenfeld

  Source: Nature reviews. Genetics. 2010 Feb

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• Controlling nuclear receptors: the circular logic of cofactor cycles.

  Nuclear receptors regulate many biologically important processes in development and homeostasis by their bimodal function as repressors and activators…

  Authors: Valentina Perissi, Michael G Rosenfeld

  Source: Nature reviews. Molecular cell biology. 2005 Jul

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• A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription.

  Multiple enzymatic activities are required for transcriptional initiation. The enzyme DNA topoisomerase II associates with gene promoter regions and c…

  Authors: Bong-Gun Ju, Victoria V Lunyak, Valentina Perissi, Ivan Garcia-Bassets, David W Rose, Christopher K Glass, Michael G Rosenfeld

  Source: Science (New York, N.Y.). 2006 Jun 23

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• A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation.

  The nuclear receptor corepressor (NCoR) and the related factor known as silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) are es…

  Authors: Sumito Ogawa, Jean Lozach, Kristen Jepsen, Dominique Sawka-Verhelle, Valentina Perissi, Roman Sasik, David W Rose, Randall S Johnson, Michael G Rosenfeld, Christopher K Glass

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2004 Oct 5

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• Tissue-specific regulation of retinal and pituitary precursor cell proliferation.

  Mammalian organogenesis requires the expansion of pluripotent precursor cells before the subsequent determination of specific cell types, but the tiss…

  Authors: Xue Li, Valentina Perissi, Forrest Liu, David W Rose, Michael G Rosenfeld

  Source: Science (New York, N.Y.). 2002 Aug 16

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