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Mechanotransduction by hair cells: models, molecules, and mechanisms.
Mechanotransduction, the transformation of mechanical force into an electrical signal, allows living organisms to hear, register movement and gravity,…
Authors: Peter G Gillespie, Ulrich Müller
Source: Cell. 2009 Oct 2
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Cadherins and mechanotransduction by hair cells.
Mechanotransduction, the conversion of a mechanical stimulus into an electrical signal is crucial for our ability to hear and to maintain balance. Rec…
Authors: Ulrich Müller
Source: Current opinion in cell biology. 2008 Oct
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Silencing the cochlear amplifier by immobilizing prestin.
Achieving the exquisite sensitivity and frequency selectivity of the mammalian ear requires active amplification of input sound. In this issue of Neur…
Authors: Ulrich Müller, Peter Gillespie
Source: Neuron. 2008 May 8
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Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells.
Hair cells of the inner ear are mechanosensors that transduce mechanical forces arising from sound waves and head movement into electrochemical signal…
Authors: Piotr Kazmierczak, Hirofumi Sakaguchi, Joshua Tokita, Elizabeth M Wilson-Kubalek, Ronald A Milligan, Ulrich Müller, Bechara Kachar
Source: Nature. 2007 Sep 6
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Industrial applications of metal-organic frameworks.
New materials are prerequisite for major breakthrough applications influencing our daily life, and therefore are pivotal for the chemical industry. Me…
Authors: Alexander U Czaja, Natalia Trukhan, Ulrich Müller
Source: Chemical Society reviews. 2009 May
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Cadherin 23 is a component of the tip link in hair-cell stereocilia.
Mechanoelectrical transduction, the conversion of mechanical force into electrochemical signals, underlies a range of sensory phenomena, including tou…
Authors: Jan Siemens, Concepcion Lillo, Rachel A Dumont, Anna Reynolds, David S Williams, Peter G Gillespie, Ulrich Müller
Source: Nature. 2004 Apr 29
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Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells.
Hair cells have highly organized bundles of apical projections, or stereocilia, that are deflected by sound and movement. Displacement of stereocilia …
Authors: Christian Söllner, Gerd-Jörg Rauch, Jan Siemens, Robert Geisler, Stephan C Schuster, Ulrich Müller, Teresa Nicolson, Tübingen 2000 Screen Consortium
Source: Nature. 2004 Apr 29
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Harmonin mutations cause mechanotransduction defects in cochlear hair cells.
In hair cells, mechanotransduction channels are gated by tip links, the extracellular filaments that consist of cadherin 23 (CDH23) and protocadherin …
Authors: Nicolas Grillet, Wei Xiong, Anna Reynolds, Piotr Kazmierczak, Takashi Sato, Concepcion Lillo, Rachel A Dumont, Edith Hintermann, Anna Sczaniecka, Martin Schwander,…
Source: Neuron. 2009 May 14
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Mutations in voltage-gated potassium channel KCNC3 cause degenerative and developmental central nervous system phenotypes.
Potassium channel mutations have been described in episodic neurological diseases. We report that K+ channel mutations cause disease phenotypes with n…
Authors: Michael F Waters, Natali A Minassian, Giovanni Stevanin, Karla P Figueroa, John P A Bannister, Dagmar Nolte, Allan F Mock, Virgilio Gerald H Evidente, Dominic B Fee, Ulrich Müller,…
Source: Nature genetics. 2006 Apr
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Mutations in LOXHD1, an evolutionarily conserved stereociliary protein, disrupt hair cell function in mice and cause progressive hearing loss in humans.
Hearing loss is the most common form of sensory impairment in humans and is frequently progressive in nature. Here we link a previously uncharacterize…
Authors: Nicolas Grillet, Martin Schwander, Michael S Hildebrand, Anna Sczaniecka, Anand Kolatkar, Janice Velasco, Jennifer A Webster, Kimia Kahrizi, Hossein Najmabadi, William J Kimberling,…
Source: American journal of human genetics. 2009 Sep
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