1 to 9 of 9 literature results

• Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system.

  Previous proteomic and transcriptional analyses of multiple sclerosis lesions revealed modulation of the renin-angiotensin and the opposing kallikrein…

  Authors: Ulf Schulze-Topphoff, Alexandre Prat, Timour Prozorovski, Volker Siffrin, Magdalena Paterka, Josephine Herz, Ivo Bendix, Igal Ifergan, Ines Schadock, Marcelo A Mori,…

  Source: Nature medicine. 2009 Jul

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• Sirt1 contributes critically to the redox-dependent fate of neural progenitors.

  Repair processes that are activated in response to neuronal injury, be it inflammatory, ischaemic, metabolic, traumatic or other cause, are characteri…

  Authors: Timour Prozorovski, Ulf Schulze-Topphoff, Robert Glumm, Jan Baumgart, Friederike Schröter, Olaf Ninnemann, Elise Siegert, Ivo Bendix, Oliver Brüstle, Robert Nitsch,…

  Source: Nature cell biology. 2008 Apr

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• Neuronal damage in autoimmune neuroinflammation mediated by the death ligand TRAIL.

  Here, we provide evidence for a detrimental role of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in neural death in T cell-induced …

  Authors: Orhan Aktas, Alina Smorodchenko, Stefan Brocke, Carmen Infante-Duarte, Ulf Schulze Topphoff, Johannes Vogt, Timour Prozorovski, Susanne Meier, Venera Osmanova, Elena Pohl,…

  Source: Neuron. 2005 May 5

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• MAPK3 deficiency drives autoimmunity via dendritic cell arming.

  Dendritic cells (DC) are professional antigen-presenting cells that instruct T cells during the inflammatory course of EAE. We have previously shown t…

  Authors: Ivo Bendix, Caspar F Pfueller, Tina Leuenberger, Nadezhda Glezeva, Volker Siffrin, Yasmin Müller, Timour Prozorovski, Wiebke Hansen, Ulf Schulze-Topphoff, Christoph Loddenkemper,…

  Source: European journal of immunology. 2010 Feb 23

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• The role of TRAIL/TRAIL receptors in central nervous system pathology.

  Initially, the tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) aroused major interest due to its preferential toxic effect again…

  Authors: Orhan Aktas, Ulf Schulze-Topphoff, Frauke Zipp

  Source: Frontiers in bioscience : a journal and virtual library. 2007

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• MMPs contribute to TNF-alpha-induced alteration of the blood-cerebrospinal fluid barrier in vitro.

  The epithelial cells of the choroid plexus separate the central nervous system from the blood forming the blood-cerebrospinal fluid (CSF) barrier. The…

  Authors: Patrick Zeni, Eva Doepker, Ulf Schulze-Topphoff, Ulf Schulze Topphoff, Sabine Huewel, Tobias Tenenbaum, Hans-Joachim Galla

  Source: American journal of physiology. Cell physiology. 2007 Sep

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• Differential immune cell dynamics in the CNS cause CD4+ T cell compartmentalization.

  In the course of autoimmune CNS inflammation, inflammatory infiltrates form characteristic perivascular lymphocyte cuffs by mechanisms that are not ye…

  Authors: Volker Siffrin, Alexander U Brandt, Helena Radbruch, Josephine Herz, Nadia Boldakowa, Tina Leuenberger, Johannes Werr, Astrid Hahner, Ulf Schulze-Topphoff, Robert Nitsch,…

  Source: Brain : a journal of neurology. 2009 May

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• TRAIL limits excessive host immune responses in bacterial meningitis.

  Apart from potential roles in anti-tumor surveillance, the TNF-related apoptosis-inducing ligand (TRAIL) has important regulatory functions in the hos…

  Authors: Olaf Hoffmann, Josef Priller, Timour Prozorovski, Ulf Schulze-Topphoff, Nevena Baeva, Jan D Lunemann, Orhan Aktas, Cordula Mahrhofer, Sarah Stricker, Frauke Zipp,…

  Source: The Journal of clinical investigation. 2007 Jul

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• Autoregulation of Th1-mediated inflammation by twist1.

  The basic helix-loop-helix transcriptional repressor twist1, as an antagonist of nuclear factor kappaB (NF-kappaB)-dependent cytokine expression, is i…

  Authors: Uwe Niesner, Inka Albrecht, Marko Janke, Cornelia Doebis, Christoph Loddenkemper, Maria H Lexberg, Katharina Eulenburg, Stephan Kreher, Juliana Koeck, Ria Baumgrass,…

  Source: The Journal of experimental medicine. 2008 Aug 4

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