1 to 10 of 57 literature results

• Carbonyl reductases: the complex relationships of mammalian carbonyl- and quinone-reducing enzymes and their role in physiology.

  Carbonyl groups are frequently found in endogenous or xenobiotic compounds. Reactive carbonyls, formed during lipid peroxidation or food processing, a…

  Authors: Udo Oppermann

  Source: Annual review of pharmacology and toxicology. 2007

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• Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.

  Post-translational histone modification has a fundamental role in chromatin biology and is proposed to constitute a 'histone code' in epigenetic regul…

  Authors: Stanley S Ng, Kathryn L Kavanagh, Michael A McDonough, Danica Butler, Ewa S Pilka, Benoit M R Lienard, James E Bray, Pavel Savitsky, Opher Gileadi, Frank von Delft,…

  Source: Nature. 2007 Jul 5

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• A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics.

  Methylation of lysine residues on the tails of histone proteins is a major determinant of the transcription state of associated DNA coding regions. Th…

  Authors: Amy M Quinn, Mark T Bedford, Alexsandra Espejo, Astrid Spannhoff, Christopher P Austin, Udo Oppermann, Anton Simeonov

  Source: Nucleic acids research. 2010 Feb

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• Investigating the genetic association between ERAP1 and ankylosing spondylitis.

  A strong association between ERAP1 and ankylosing spondylitis (AS) was recently identified by the Wellcome Trust Case Control Consortium and the Austr…

  Authors: David Harvey, Jennifer J Pointon, David M Evans, Tugce Karaderi, Claire Farrar, Louise H Appleton, Roger D Sturrock, Millicent A Stone, Udo Oppermann, Matthew A Brown,…

  Source: Human molecular genetics. 2009 Nov 1

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• Structural basis for different specificities of acyltransferases associated with the human cytosolic and mitochondrial fatty acid synthases.

  Animals employ two systems for the de novo biosynthesis of fatty acids: a megasynthase complex in the cytosol (type I) that produces mainly palmitate,…

  Authors: Gabor Bunkoczi, Stephanie Misquitta, Xiaoqiu Wu, Wen Hwa Lee, Alexandra Rojkova, Grazyna Kochan, Kathryn L Kavanagh, Udo Oppermann, Stuart Smith

  Source: Chemistry & biology. 2009 Jun 26

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• Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A.

  Acyl-CoA synthetases belong to the superfamily of adenylate-forming enzymes, and catalyze the two-step activation of fatty acids or carboxylate-contai…

  Authors: Grazyna Kochan, Ewa S Pilka, Frank von Delft, Udo Oppermann, Wyatt W Yue

  Source: Journal of molecular biology. 2009 May 22

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• Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase.

  Crystallographic analysis of the catalytic domain of PHD finger protein 8 (PHF8), an N(epsilon)-methyl lysine histone demethylase associated with ment…

  Authors: Wyatt W Yue, Viktorija Hozjan, Wei Ge, Christoph Loenarz, Christopher D O Cooper, Christopher J Schofield, Kathryn L Kavanagh, Udo Oppermann, Michael A McDonough

  Source: FEBS letters. 2010 Feb 19

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• Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.

  Ferrous ion and 2-oxoglutarate (2OG) oxygenases catalyze the demethylation of N(epsilon)-methylated lysine residues in histones. Here we report studie…

  Authors: Nathan R Rose, Esther C Y Woon, Guy L Kingham, Oliver N F King, Jasmin Mecinović, Ian J Clifton, Stanley S Ng, Jobina Talib-Hardy, Udo Oppermann, Michael A McDonough,…

  Source: Journal of medicinal chemistry. 2010 Feb 25

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• Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis.

  Cryptosporidiosis is a neglected disease without a wholly effective drug. We present a study demonstrating nitrogen-containing bisphosphonates (N-BPs)…

  Authors: Jennifer D Artz, James E Dunford, Michael J Arrowood, Aiping Dong, Maksymilian Chruszcz, Kathryn L Kavanagh, Wladek Minor, R Graham G Russell, F Hal Ebetino, Udo Oppermann,…

  Source: Chemistry & biology. 2008 Dec 22

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• SALMON: solvent accessibility, ligand binding, and mapping of ligand orientation by NMR spectroscopy.

  Quinone oxidoreductase 2 (NQO2) binds the prodrug tretazicar (also known as CB1954, 5-(aziridin-1-yl)-2,4-dinitrobenzamide), which exhibits a profound…

  Authors: Christian Ludwig, Paul J A Michiels, Xiaoqiu Wu, Kathryn L Kavanagh, Ewa Pilka, Anna Jansson, Udo Oppermann, Ulrich L Günther

  Source: Journal of medicinal chemistry. 2008 Jan 10

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