1 to 10 of 93 literature results

• MicroRNAs and cancer: short RNAs go a long way.

  MicroRNAs (miRNAs) may be important regulators of gene expression. By modulating oncogenic and tumor suppressor pathways they could, in principle, con…

  Authors: Andrea Ventura, Tyler Jacks

  Source: Cell. 2009 Feb 20

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• Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma.

  NF-kappaB transcription factors function as crucial regulators of inflammatory and immune responses as well as of cell survival. They have also been i…

  Authors: Etienne Meylan, Alison L Dooley, David M Feldser, Lynn Shen, Erin Turk, Chensi Ouyang, Tyler Jacks

  Source: Nature. 2009 Nov 5

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• Impaired microRNA processing enhances cellular transformation and tumorigenesis.

  MicroRNAs (miRNAs) are a new class of small noncoding RNAs that post-transcriptionally regulate the expression of target mRNA transcripts. Many of the…

  Authors: Madhu S Kumar, Jun Lu, Kim L Mercer, Todd R Golub, Tyler Jacks

  Source: Nature genetics. 2007 May

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• Restoration of p53 function leads to tumour regression in vivo.

  Tumorigenesis is a multi-step process that requires activation of oncogenes and inactivation of tumour suppressor genes. Mouse models of human cancers…

  Authors: Andrea Ventura, David G Kirsch, Margaret E McLaughlin, David A Tuveson, Jan Grimm, Laura Lintault, Jamie Newman, Elizabeth E Reczek, Ralph Weissleder, Tyler Jacks

  Source: Nature. 2007 Feb 8

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• Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals.

  There is growing recognition that mammalian cells produce many thousands of large intergenic transcripts. However, the functional significance of thes…

  Authors: Mitchell Guttman, Ido Amit, Manuel Garber, Courtney French, Michael F Lin, David Feldser, Maite Huarte, Or Zuk, Bryce W Carey, John P Cassady,…

  Source: Nature. 2009 Mar 12

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• Dicer1 functions as a haploinsufficient tumor suppressor.

  While the global down-regulation of microRNAs (miRNAs) is a common feature of human tumors, its genetic basis is largely undefined. To explore this qu…

  Authors: Madhu S Kumar, Ryan E Pester, Cindy Y Chen, Keara Lane, Christine Chin, Jun Lu, David G Kirsch, Todd R Golub, Tyler Jacks

  Source: Genes & development. 2009 Dec 1

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• Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells.

  An alternative to therapeutic targeting of oncogenes is to perform "synthetic lethality" screens for genes that are essential only in the context of s…

  Authors: Claudia Scholl, Stefan Fröhling, Ian F Dunn, Anna C Schinzel, David A Barbie, So Young Kim, Serena J Silver, Pablo Tamayo, Raymond C Wadlow, Sridhar Ramaswamy,…

  Source: Cell. 2009 May 29

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• Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras.

  Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human malignancies. To investigate the cellular origin(s) of this cancer, we determi…

  Authors: Sharon Y Gidekel Friedlander, Gerald C Chu, Eric L Snyder, Nomeda Girnius, Gregory Dibelius, Denise Crowley, Eliza Vasile, Ronald A DePinho, Tyler Jacks

  Source: Cancer cell. 2009 Nov 6

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• Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.

  Kras is commonly mutated in colon cancers, but mutations in Nras are rare. We have used genetically engineered mice to determine whether and how these…

  Authors: Kevin M Haigis, Krystle R Kendall, Yufang Wang, Ann Cheung, Marcia C Haigis, Jonathan N Glickman, Michiko Niwa-Kawakita, Alejandro Sweet-Cordero, Judith Sebolt-Leopold, Kevin M Shannon,…

  Source: Nature genetics. 2008 May

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• Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters.

  miR-17 approximately 92, miR-106b approximately 25, and miR-106a approximately 363 belong to a family of highly conserved miRNA clusters. Amplificatio…

  Authors: Andrea Ventura, Amanda G Young, Monte M Winslow, Laura Lintault, Alex Meissner, Stefan J Erkeland, Jamie Newman, Roderick T Bronson, Denise Crowley, James R Stone,…

  Source: Cell. 2008 Mar 7

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