1 to 10 of 47 literature results

• The somatostatin analogue octreotide confers sensitivity to rapamycin treatment on pituitary tumor cells.

  Rapamycin and its analogues have significant antiproliferative action against a variety of tumors. However, sensitivity to rapamycin is reduced by Akt…

  Authors: Vesna Cerovac, Jose Monteserin-Garcia, Hadara Rubinfeld, Michael Buchfelder, Marco Losa, Tullio Florio, Marcelo Paez-Pereda, Günter K Stalla, Marily Theodoropoulou

  Source: Cancer research. 2010 Jan 15

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• Somatostatin/somatostatin receptor signalling: phosphotyrosine phosphatases.

  Activation of phosphotyrosine phosphatases (PTPs) by somatostatin receptor (SSTR) represents one of the main intracellular mechanisms involved in the …

  Authors: Tullio Florio

  Source: Molecular and cellular endocrinology. 2008 May 14

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• Efficacy of a dopamine-somatostatin chimeric molecule, BIM-23A760, in the control of cell growth from primary cultures of human non-functioning pituitary adenomas: a multi-center study.

  Dopamine D2 and somatostatin receptors (sstrs) were reported to affect non-functioning pituitary adenoma (NFPA) proliferation in vitro. However, the r…

  Authors: Tullio Florio, Federica Barbieri, Renato Spaziante, Gianluigi Zona, Leo J Hofland, Peter M van Koetsveld, Richard A Feelders, Günter K Stalla, Marily Theodoropoulou, Michael D Culler,…

  Source: Endocrine-related cancer. 2008 Jun

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• Octreotide, a somatostatin analogue, mediates its antiproliferative action in pituitary tumor cells by altering phosphatidylinositol 3-kinase signaling and inducing Zac1 expression.

  Somatostatin limits cell growth by inhibiting the proliferative activity of growth factor receptors. In this study, it is shown that in pituitary tumo…

  Authors: Marily Theodoropoulou, Jing Zhang, Sandra Laupheimer, Marcelo Paez-Pereda, Christophe Erneux, Tullio Florio, Uberto Pagotto, Günter K Stalla

  Source: Cancer research. 2006 Feb 1

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• Somatostatin receptors 1, 2, and 5 cooperate in the somatostatin inhibition of C6 glioma cell proliferation in vitro via a phosphotyrosine phosphatase-eta-dependent inhibition of extracellularly regulated kinase-1/2.

  Somatostatin inhibits cell proliferation through the activation of five receptors (SSTR1-5) expressed in normal and cancer cells. We analyzed the role…

  Authors: Federica Barbieri, Alessandra Pattarozzi, Monica Gatti, Carola Porcile, Adriana Bajetto, Angelo Ferrari, Michael D Culler, Tullio Florio

  Source: Endocrinology. 2008 Sep

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• 17beta-estradiol promotes breast cancer cell proliferation-inducing stromal cell-derived factor-1-mediated epidermal growth factor receptor transactivation: reversal by gefitinib pretreatment.

  The coordinated activity of estrogens and epidermal growth factor receptor (EGFR) family agonists represents the main determinant of breast cancer cel…

  Authors: Alessandra Pattarozzi, Monica Gatti, Federica Barbieri, Roberto Würth, Carola Porcile, Gianluigi Lunardi, Alessandra Ratto, Roberto Favoni, Adriana Bajetto, Angelo Ferrari,…

  Source: Molecular pharmacology. 2008 Jan

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• Role of stromal cell-derived factor 1 (SDF1/CXCL12) in regulating anterior pituitary function.

  Chemokines are key factors involved in the regulation of immune response, through the activation and control of leukocyte traffic, lymphopoiesis and i…

  Authors: Federica Barbieri, Adriana Bajetto, Carola Porcile, Alessandra Pattarozzi, Gennaro Schettini, Tullio Florio

  Source: Journal of molecular endocrinology. 2007 Mar

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• Chemokine stromal cell-derived factor 1alpha induces proliferation and growth hormone release in GH4C1 rat pituitary adenoma cell line through multiple intracellular signals.

  We used GH4C1 cells as a model to study the effects of the chemokine stromal cell-derived factor 1 (SDF1) in pituitary functions. In these cells, SDF1…

  Authors: Tullio Florio, Silvia Casagrande, Fabrizio Diana, Adriana Bajetto, Carola Porcile, Gianluigi Zona, Stefano Thellung, Sara Arena, Alessandra Pattarozzi, Alessandro Corsaro,…

  Source: Molecular pharmacology. 2006 Feb

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• Intracellular accumulation of a mild-denatured monomer of the human PrP fragment 90-231, as possible mechanism of its neurotoxic effects.

  Because of high tendency of the prion protein (PrP) to aggregate, the exact PrP isoform responsible for prion diseases as well as the pathological mec…

  Authors: Katia Chiovitti, Alessandro Corsaro, Stefano Thellung, Valentina Villa, Domenico Paludi, Cristina D'Arrigo, Claudio Russo, Angelo Perico, Adriana Ianieri, Domenico Di Cola,…

  Source: Journal of neurochemistry. 2007 Dec

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• ERK1/2 and p38 MAP kinases control prion protein fragment 90-231-induced astrocyte proliferation and microglia activation.

  Astrogliosis and microglial activation are a common feature during prion diseases, causing the release of chemoattractant and proinflammatory factors …

  Authors: Stefano Thellung, Valentina Villa, Alessandro Corsaro, Francesca Pellistri, Valentina Venezia, Claudio Russo, Antonio Aceto, Mauro Robello, Tullio Florio

  Source: Glia. 2007 Nov 1

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