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1 to 10 of 16 literature results
CLC-0 and cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channels play important roles in Cl(-) transport across cell membranes. The…
Authors: Tsung-Yu Chen, Tzyh-Chang Hwang
Source: Physiological reviews. 2008 Apr
View Full TextThe CLC family comprises a group of integral membrane proteins whose major action is to translocate chloride (Cl-) ions across the cell membranes. Rec…
Authors: Tsung-Yu Chen
Source: Annual review of physiology. 2005
View Full TextUsing the substituted-cysteine-accessibility method, we previously showed that a cysteine residue introduced to the Y512 position of CLC-0 was more ra…
Authors: Xiao-Dong Zhang, Wei-Ping Yu, Tsung-Yu Chen
Source: Biophysical journal. 2010 Feb 3
View Full TextOxidation and reduction (redox) are known to modulate the function of a variety of ion channels. Here, we report a redox regulation of the function of…
Authors: Yong Li, Wei-Ping Yu, Chia-Wei Lin, Tsung-Yu Chen
Source: Biophysical journal. 2005 Jun
View Free Full TextThe effect of intracellular adenosine triphosphate (ATP) on the "common gating" of the CLC-1 chloride channel has been studied by several laboratories…
Authors: Xiao-Dong Zhang, Pang-Yen Tseng, Tsung-Yu Chen
Source: The Journal of general physiology. 2008 Oct
View Full TextIntracellularly applied amphiphilic molecules, such as p-chlorophenoxy acetate (CPA) and octanoate, block various pore-open mutants of CLC-0. The volt…
Authors: Xiao-Dong Zhang, Tsung-Yu Chen
Source: The Journal of general physiology. 2009 Jan
View Full TextThe blockade of CLC-0 chloride channels by p-chlorophenoxy acetate (CPA) has been thought to be state dependent; the conformational change of the chan…
Authors: Xiao-Dong Zhang, Pang-Yen Tseng, Wei-Ping Yu, Tsung-Yu Chen
Source: The Journal of general physiology. 2009 Jan
View Full TextThe cyclic calcium release and uptake during calcium oscillation are thought to result from calcium-induced calcium release (CICR); however, it is unc…
Authors: Yung-Hsiang Yi, Pei-Yun Ho, Tung-Wei Chen, Wen-Jie Lin, Vladimir Gukassyan, Tsung-Heng Tsai, Da-Wei Wang, Tien-Shen Lew, Chih-Yung Tang, Szecheng J Lo,…
Source: The Journal of biological chemistry. 2009 Feb 6
View Full TextThe CLC-1 Cl(-) channel is abundantly expressed on the plasma membrane of muscle cells, and the membrane potential of muscle cells is largely controll…
Authors: Pang-Yen Tseng, Brett Bennetts, Tsung-Yu Chen
Source: The Journal of general physiology. 2007 Aug
View Free Full TextThe charge on the side chain of the internal pore residue lysine 519 (K519) of the Torpedo ClC-0 chloride (Cl-) channel affects channel conductance. E…
Authors: Mei-Fang Chen, Tsung-Yu Chen
Source: The Journal of general physiology. 2003 Aug
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