1 to 10 of 16 literature results

• CLC-0 and CFTR: chloride channels evolved from transporters.

  CLC-0 and cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channels play important roles in Cl(-) transport across cell membranes. The…

  Authors: Tsung-Yu Chen, Tzyh-Chang Hwang

  Source: Physiological reviews. 2008 Apr

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• Structure and function of clc channels.

  The CLC family comprises a group of integral membrane proteins whose major action is to translocate chloride (Cl-) ions across the cell membranes. Rec…

  Authors: Tsung-Yu Chen

  Source: Annual review of physiology. 2005

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• Accessibility of the CLC-0 pore to charged methanethiosulfonate reagents.

  Using the substituted-cysteine-accessibility method, we previously showed that a cysteine residue introduced to the Y512 position of CLC-0 was more ra…

  Authors: Xiao-Dong Zhang, Wei-Ping Yu, Tsung-Yu Chen

  Source: Biophysical journal. 2010 Feb 3

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• Oxidation and reduction control of the inactivation gating of Torpedo ClC-0 chloride channels.

  Oxidation and reduction (redox) are known to modulate the function of a variety of ion channels. Here, we report a redox regulation of the function of…

  Authors: Yong Li, Wei-Ping Yu, Chia-Wei Lin, Tsung-Yu Chen

  Source: Biophysical journal. 2005 Jun

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• ATP inhibition of CLC-1 is controlled by oxidation and reduction.

  The effect of intracellular adenosine triphosphate (ATP) on the "common gating" of the CLC-1 chloride channel has been studied by several laboratories…

  Authors: Xiao-Dong Zhang, Pang-Yen Tseng, Tsung-Yu Chen

  Source: The Journal of general physiology. 2008 Oct

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• Amphiphilic blockers punch through a mutant CLC-0 pore.

  Intracellularly applied amphiphilic molecules, such as p-chlorophenoxy acetate (CPA) and octanoate, block various pore-open mutants of CLC-0. The volt…

  Authors: Xiao-Dong Zhang, Tsung-Yu Chen

  Source: The Journal of general physiology. 2009 Jan

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• Blocking pore-open mutants of CLC-0 by amphiphilic blockers.

  The blockade of CLC-0 chloride channels by p-chlorophenoxy acetate (CPA) has been thought to be state dependent; the conformational change of the chan…

  Authors: Xiao-Dong Zhang, Pang-Yen Tseng, Wei-Ping Yu, Tsung-Yu Chen

  Source: The Journal of general physiology. 2009 Jan

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• Membrane targeting and coupling of NHE1-integrinalphaIIbbeta3-NCX1 by lipid rafts following integrin-ligand interactions trigger Ca2+ oscillations.

  The cyclic calcium release and uptake during calcium oscillation are thought to result from calcium-induced calcium release (CICR); however, it is unc…

  Authors: Yung-Hsiang Yi, Pei-Yun Ho, Tung-Wei Chen, Wen-Jie Lin, Vladimir Gukassyan, Tsung-Heng Tsai, Da-Wei Wang, Tien-Shen Lew, Chih-Yung Tang, Szecheng J Lo,…

  Source: The Journal of biological chemistry. 2009 Feb 6

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• Cytoplasmic ATP inhibition of CLC-1 is enhanced by low pH.

  The CLC-1 Cl(-) channel is abundantly expressed on the plasma membrane of muscle cells, and the membrane potential of muscle cells is largely controll…

  Authors: Pang-Yen Tseng, Brett Bennetts, Tsung-Yu Chen

  Source: The Journal of general physiology. 2007 Aug

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• Side-chain charge effects and conductance determinants in the pore of ClC-0 chloride channels.

  The charge on the side chain of the internal pore residue lysine 519 (K519) of the Torpedo ClC-0 chloride (Cl-) channel affects channel conductance. E…

  Authors: Mei-Fang Chen, Tsung-Yu Chen

  Source: The Journal of general physiology. 2003 Aug

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