1 to 10 of 11 literature results

• Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization.

  Controversy surrounds the role and mechanism of mitochondrial cristae remodeling in apoptosis. Here we show that the proapoptotic BH3-only proteins Bi…

  Authors: Ryuji Yamaguchi, Lydia Lartigue, Guy Perkins, Ray T Scott, Amruta Dixit, Yulia Kushnareva, Tomomi Kuwana, Mark H Ellisman, Donald D Newmeyer

  Source: Molecular cell. 2008 Aug 22

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• Bcl-2-family proteins and the role of mitochondria in apoptosis.

  Mitochondria are central to many forms of cell death, usually via the release of pro-apoptotic proteins from the mitochondrial intermembrane space. So…

  Authors: Tomomi Kuwana, Donald D Newmeyer

  Source: Current opinion in cell biology. 2003 Dec

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• Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization.

  Mitochondrial fusion and division play important roles in the regulation of apoptosis. Mitochondrial fusion proteins attenuate apoptosis by inhibiting…

  Authors: Ann Cassidy-Stone, Jerry E Chipuk, Elena Ingerman, Cheng Song, Choong Yoo, Tomomi Kuwana, Mark J Kurth, Jared T Shaw, Jenny E Hinshaw, Douglas R Green,…

  Source: Developmental cell. 2008 Feb

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• BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly.

  Using a Bax-dependent membrane-permeabilization assay, we show that peptides corresponding to the BH3 domains of Bcl-2 family "BH3-only" proteins have…

  Authors: Tomomi Kuwana, Lisa Bouchier-Hayes, Jerry E Chipuk, Christine Bonzon, Barbara A Sullivan, Douglas R Green, Donald D Newmeyer

  Source: Molecular cell. 2005 Feb 18

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• Mitochondrial outer membrane proteins assist Bid in Bax-mediated lipidic pore formation.

  Mitochondrial outer membrane permeabilization (MOMP) is a critical step in apoptosis and is regulated by Bcl-2 family proteins. In vitro systems using…

  Authors: Blanca Schafer, Joel Quispe, Vineet Choudhary, Jerry E Chipuk, Teddy G Ajero, Han Du, Roger Schneiter, Tomomi Kuwana

  Source: Molecular biology of the cell. 2009 Apr

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• Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane.

  Bcl-2 family proteins regulate the release of proteins like cytochrome c from mitochondria during apoptosis. We used cell-free systems and ultimately …

  Authors: Tomomi Kuwana, Mason R Mackey, Guy Perkins, Mark H Ellisman, Martin Latterich, Roger Schneiter, Douglas R Green, Donald D Newmeyer

  Source: Cell. 2002 Nov 1

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• Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins.

  Normal cellular lifespan is contingent upon preserving outer mitochondrial membrane (OMM) integrity, as permeabilization promotes apoptosis. BCL-2 fam…

  Authors: Jerry E Chipuk, John C Fisher, Christopher P Dillon, Richard W Kriwacki, Tomomi Kuwana, Douglas R Green

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2008 Dec 23

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• Caspase inhibition blocks cell death and results in cell cycle arrest in cytokine-deprived hematopoietic cells.

  Cytokine deprivation has been classically used to study molecular processes of apoptosis. Following interleukin (IL)-3 withdrawal in FL5.12 cells, Bax…

  Authors: Nicholas M Brown, Sean M Martin, Nick Maurice, Tomomi Kuwana, C Michael Knudson

  Source: The Journal of biological chemistry. 2007 Jan 26

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• The multidomain proapoptotic molecules Bax and Bak are directly activated by heat.

  During apoptosis, engagement of the mitochondrial pathway involves a decisive event characterized by the release of mitochondrial intermembrane space …

  Authors: Lisa J Pagliari, Tomomi Kuwana, Christine Bonzon, Donald D Newmeyer, Shine Tu, Helen M Beere, Douglas R Green

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2005 Dec 13

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• PUMA couples the nuclear and cytoplasmic proapoptotic function of p53.

  The Trp53 tumor suppressor gene product (p53) functions in the nucleus to regulate proapoptotic genes, whereas cytoplasmic p53 directly activates proa…

  Authors: Jerry E Chipuk, Lisa Bouchier-Hayes, Tomomi Kuwana, Donald D Newmeyer, Douglas R Green

  Source: Science (New York, N.Y.). 2005 Sep 9

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