1 to 10 of 97 literature results

• Identification of RPS14 as a 5q- syndrome gene by RNA interference screen.

  Somatic chromosomal deletions in cancer are thought to indicate the location of tumour suppressor genes, by which a complete loss of gene function occ…

  Authors: Benjamin L Ebert, Jennifer Pretz, Jocelyn Bosco, Cindy Y Chang, Pablo Tamayo, Naomi Galili, Azra Raza, David E Root, Eyal Attar, Steven R Ellis,…

  Source: Nature. 2008 Jan 17

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• Impaired microRNA processing enhances cellular transformation and tumorigenesis.

  MicroRNAs (miRNAs) are a new class of small noncoding RNAs that post-transcriptionally regulate the expression of target mRNA transcripts. Many of the…

  Authors: Madhu S Kumar, Jun Lu, Kim L Mercer, Todd R Golub, Tyler Jacks

  Source: Nature genetics. 2007 May

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• Genomics: global views of leukaemia.

  Authors: Todd R Golub

  Source: Nature. 2007 Apr 12

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• Toward a functional taxonomy of cancer.

  Interrogating the genomes of tumor cells with genomic and proteomic methods is becoming a mainstay of modern cancer classification efforts. This notio…

  Authors: Todd R Golub

  Source: Cancer cell. 2004 Aug

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• The landscape of somatic copy-number alteration across human cancers.

  A powerful way to discover key genes with causal roles in oncogenesis is to identify genomic regions that undergo frequent alteration in human cancers…

  Authors: Rameen Beroukhim, Craig H Mermel, Dale Porter, Guo Wei, Soumya Raychaudhuri, Jerry Donovan, Jordi Barretina, Jesse S Boehm, Jennifer Dobson, Mitsuyoshi Urashima,…

  Source: Nature. 2010 Feb 18

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• Dicer1 functions as a haploinsufficient tumor suppressor.

  While the global down-regulation of microRNAs (miRNAs) is a common feature of human tumors, its genetic basis is largely undefined. To explore this qu…

  Authors: Madhu S Kumar, Ryan E Pester, Cindy Y Chen, Keara Lane, Christine Chin, Jun Lu, David G Kirsch, Todd R Golub, Tyler Jacks

  Source: Genes & development. 2009 Dec 1

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• Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

  Leukaemias and other cancers possess a rare population of cells capable of the limitless self-renewal necessary for cancer initiation and maintenance.…

  Authors: Andrei V Krivtsov, David Twomey, Zhaohui Feng, Matthew C Stubbs, Yingzi Wang, Joerg Faber, Jason E Levine, Jing Wang, William C Hahn, D Gary Gilliland,…

  Source: Nature. 2006 Aug 17

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• Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals.

  Comprehensive identification of all functional elements encoded in the human genome is a fundamental need in biomedical research. Here, we present a c…

  Authors: Xiaohui Xie, Jun Lu, E J Kulbokas, Todd R Golub, Vamsi Mootha, Kerstin Lindblad-Toh, Eric S Lander, Manolis Kellis

  Source: Nature. 2005 Mar 17

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• Lin28 promotes transformation and is associated with advanced human malignancies.

  Multiple members of the let-7 family of miRNAs are often repressed in human cancers, thereby promoting oncogenesis by derepressing targets such as HMG…

  Authors: Srinivas R Viswanathan, John T Powers, William Einhorn, Yujin Hoshida, Tony L Ng, Sara Toffanin, Maureen O'Sullivan, Jun Lu, Letha A Phillips, Victoria L Lockhart,…

  Source: Nature genetics. 2009 Jul

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• MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer.

  While altered expression of microRNAs (miRs) in tumors has been well documented, it remains unclear how the miR transcriptome intersects neoplastic pr…

  Authors: Peter Olson, Jun Lu, Hao Zhang, Anny Shai, Matthew G Chun, Yucheng Wang, Steven K Libutti, Eric K Nakakura, Todd R Golub, Douglas Hanahan

  Source: Genes & development. 2009 Sep 15

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