1 to 10 of 23 literature results

• Genes mirror geography within Europe.

  Understanding the genetic structure of human populations is of fundamental interest to medical, forensic and anthropological sciences. Advances in hig…

  Authors: John Novembre, Toby Johnson, Katarzyna Bryc, Zoltán Kutalik, Adam R Boyko, Adam Auton, Amit Indap, Karen S King, Sven Bergmann, Matthew R Nelson,…

  Source: Nature. 2008 Nov 6

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• Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms.

  Uric acid (UA) is the final catabolic product of purine metabolism and elevated levels are associated with diabetes and cardiovascular disease. A rece…

  Authors: Pim van der Harst, Stephan J L Bakker, Rudolf A de Boer, Bruce H R Wolffenbuttel, Toby Johnson, Mark J Caulfield, Gerjan Navis

  Source: Human molecular genetics. 2010 Jan 15

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• Genome-wide association analysis identifies 20 loci that influence adult height.

  Adult height is a model polygenic trait, but there has been limited success in identifying the genes underlying its normal variation. To identify gene…

  Authors: Michael N Weedon, Hana Lango, Cecilia M Lindgren, Chris Wallace, David M Evans, Massimo Mangino, Rachel M Freathy, John R B Perry, Suzanne Stevens, Alistair S Hall,…

  Source: Nature genetics. 2008 May

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• Genome-wide association study identifies five loci associated with lung function.

  Pulmonary function measures are heritable traits that predict morbidity and mortality and define chronic obstructive pulmonary disease (COPD). We test…

  Authors: Emmanouela Repapi, Ian Sayers, Louise V Wain, Paul R Burton, Toby Johnson, Ma'en Obeidat, Jing Hua Zhao, Adaikalavan Ramasamy, Guangju Zhai, Veronique Vitart,…

  Source: Nature genetics. 2010 Jan

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• LDL-cholesterol concentrations: a genome-wide association study.

  BACKGROUND: LDL cholesterol has a causal role in the development of cardiovascular disease. Improved understanding of the biological mechanisms that u…

  Authors: Manjinder S Sandhu, Dawn M Waterworth, Sally L Debenham, Eleanor Wheeler, Konstantinos Papadakis, Jing Hua Zhao, Kijoung Song, Xin Yuan, Toby Johnson, Sofie Ashford,…

  Source: Lancet. 2008 Feb 9

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• MCALIGN: stochastic alignment of noncoding DNA sequences based on an evolutionary model of sequence evolution.

  A method is described for performing global alignment of noncoding DNA sequences based on an evolutionary model parameterized by the frequency distrib…

  Authors: Peter D Keightley, Toby Johnson

  Source: Genome research. 2004 Mar

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• New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.

  Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide as…

  Authors: Josée Dupuis, Claudia Langenberg, Inga Prokopenko, Richa Saxena, Nicole Soranzo, Anne U Jackson, Eleanor Wheeler, Nicole L Glazer, Nabila Bouatia-Naji, Anna L Gloyn,…

  Source: Nature genetics. 2010 Feb

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• Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.

  Glucose levels 2 h after an oral glucose challenge are a clinical measure of glucose tolerance used in the diagnosis of type 2 diabetes. We report a m…

  Authors: Richa Saxena, Marie-France Hivert, Claudia Langenberg, Toshiko Tanaka, James S Pankow, Peter Vollenweider, Valeriya Lyssenko, Nabila Bouatia-Naji, Josée Dupuis, Anne U Jackson,…

  Source: Nature genetics. 2010 Feb

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• Variants in MTNR1B influence fasting glucose levels.

  To identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-…

  Authors: Inga Prokopenko, Claudia Langenberg, Jose C Florez, Richa Saxena, Nicole Soranzo, Gudmar Thorleifsson, Ruth J F Loos, Alisa K Manning, Anne U Jackson, Yurii Aulchenko,…

  Source: Nature genetics. 2009 Jan

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• Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

  Blood lipids are important cardiovascular disease (CVD) risk factors with both genetic and environmental determinants. The Whitehall II study (n=5592)…

  Authors: Philippa J Talmud, Fotios Drenos, Sonia Shah, Tina Shah, Jutta Palmen, Claudio Verzilli, Tom R Gaunt, Jacky Pallas, Ruth Lovering, Kawah Li,…

  Source: American journal of human genetics. 2009 Nov

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