1 to 6 of 6 literature results

• Myc deletion rescues Apc deficiency in the small intestine.

  The APC gene encodes the adenomatous polyposis coli tumour suppressor protein, germline mutation of which characterizes familial adenomatous polyposis…

  Authors: Owen J Sansom, Valerie S Meniel, Vanesa Muncan, Toby J Phesse, Julie A Wilkins, Karen R Reed, J Keith Vass, Dimitris Athineos, Hans Clevers, Alan R Clarke

  Source: Nature. 2007 Apr 5

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• gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.

  Although gastrointestinal cancers are frequently associated with chronic inflammation, the underlying molecular links have not been comprehensively de…

  Authors: Julia Bollrath, Toby J Phesse, Vivian A von Burstin, Tracy Putoczki, Moritz Bennecke, Trudie Bateman, Tim Nebelsiek, Therese Lundgren-May, Ozge Canli, Sarah Schwitalla,…

  Source: Cancer cell. 2009 Feb 3

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• K-ras and Wnt signaling synergize to accelerate prostate tumorigenesis in the mouse.

  Aberrant Ras and Wnt signaling are emerging as key events in the multistep nature of prostate tumorigenesis and progression. Here, we report the gener…

  Authors: Helen B Pearson, Toby J Phesse, Alan R Clarke

  Source: Cancer research. 2009 Jan 1

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• Liver zonation occurs through a beta-catenin-dependent, c-Myc-independent mechanism.

  BACKGROUND AND AIMS: The Wnt pathway has previously been shown to play a role in hepatic zonation. Herein, we have explored the role of 3 key componen…

  Authors: Zoé D Burke, Karen R Reed, Toby J Phesse, Owen J Sansom, Alan R Clarke, David Tosh

  Source: Gastroenterology. 2009 Jun

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• Deficiency of Mbd2 attenuates Wnt signaling.

  We have previously shown that deficiency of the methyl binding domain protein Mbd2 dramatically reduces adenoma burden on an Apc(Min/+) background. To…

  Authors: Toby J Phesse, Lee Parry, Karen R Reed, Kenneth B Ewan, Trevor C Dale, Owen J Sansom, Alan R Clarke

  Source: Molecular and cellular biology. 2008 Oct

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• Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc.

  Inhibition of the mutationally activated Wnt cascade in colorectal cancer cell lines induces a rapid G1 arrest and subsequent differentiation. This ar…

  Authors: Vanesa Muncan, Owen J Sansom, Leon Tertoolen, Toby J Phesse, Harry Begthel, Elena Sancho, Alicia M Cole, Alex Gregorieff, Ignacio Moreno de Alboran, Hans Clevers,…

  Source: Molecular and cellular biology. 2006 Nov

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