1 to 10 of 11 literature results

• Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system.

  Previous proteomic and transcriptional analyses of multiple sclerosis lesions revealed modulation of the renin-angiotensin and the opposing kallikrein…

  Authors: Ulf Schulze-Topphoff, Alexandre Prat, Timour Prozorovski, Volker Siffrin, Magdalena Paterka, Josephine Herz, Ivo Bendix, Igal Ifergan, Ines Schadock, Marcelo A Mori,…

  Source: Nature medicine. 2009 Jul

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• Sirt1 contributes critically to the redox-dependent fate of neural progenitors.

  Repair processes that are activated in response to neuronal injury, be it inflammatory, ischaemic, metabolic, traumatic or other cause, are characteri…

  Authors: Timour Prozorovski, Ulf Schulze-Topphoff, Robert Glumm, Jan Baumgart, Friederike Schröter, Olaf Ninnemann, Elise Siegert, Ivo Bendix, Oliver Brüstle, Robert Nitsch,…

  Source: Nature cell biology. 2008 Apr

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• Neuronal damage in autoimmune neuroinflammation mediated by the death ligand TRAIL.

  Here, we provide evidence for a detrimental role of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in neural death in T cell-induced …

  Authors: Orhan Aktas, Alina Smorodchenko, Stefan Brocke, Carmen Infante-Duarte, Ulf Schulze Topphoff, Johannes Vogt, Timour Prozorovski, Susanne Meier, Venera Osmanova, Elena Pohl,…

  Source: Neuron. 2005 May 5

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• Death ligands and autoimmune demyelination.

  Death ligands induce apoptosis, which is a cell suicide program leading mainly to selective elimination of an organism's useless cells. Importantly, t…

  Authors: Orhan Aktas, Timour Prozorovski, Frauke Zipp

  Source: The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 2006 Aug

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• Mouse model mimics multiple sclerosis in the clinico-radiological paradox.

  The value of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, in deriving novel diagnostic and therapeutic inpu…

  Authors: Jens Wuerfel, Eva Tysiak, Timour Prozorovski, Maureen Smyth, Susanne Mueller, Joerg Schnorr, Matthias Taupitz, Frauke Zipp

  Source: The European journal of neuroscience. 2007 Jul

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• Geranylgeranylation but not GTP loading determines rho migratory function in T cells.

  Rho GTPases orchestrate signaling pathways leading to cell migration. Their function depends on GTP loading and isoprenylation by geranylgeranyl pyrop…

  Authors: Sonia Waiczies, Ivo Bendix, Timour Prozorovski, Maya Ratner, Irina Nazarenko, Caspar F Pfueller, Alexander U Brandt, Josephine Herz, Stefan Brocke, Oliver Ullrich,…

  Source: Journal of immunology (Baltimore, Md. : 1950). 2007 Nov 1

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• TRAIL limits excessive host immune responses in bacterial meningitis.

  Apart from potential roles in anti-tumor surveillance, the TNF-related apoptosis-inducing ligand (TRAIL) has important regulatory functions in the hos…

  Authors: Olaf Hoffmann, Josef Priller, Timour Prozorovski, Ulf Schulze-Topphoff, Nevena Baeva, Jan D Lunemann, Orhan Aktas, Cordula Mahrhofer, Sarah Stricker, Frauke Zipp,…

  Source: The Journal of clinical investigation. 2007 Jul

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• Atorvastatin induces T cell anergy via phosphorylation of ERK1.

  Modulation of T cell response is a novel property of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors. Previously we reported the benefits of…

  Authors: Sonia Waiczies, Timour Prozorovski, Carmen Infante-Duarte, Astrid Hahner, Orhan Aktas, Oliver Ullrich, Frauke Zipp

  Source: Journal of immunology (Baltimore, Md. : 1950). 2005 May 1

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• Frequency of blood CX3CR1-positive natural killer cells correlates with disease activity in multiple sclerosis patients.

  Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) characterized by enormous variability in its clinical presentatio…

  Authors: Carmen Infante-Duarte, Alexandra Weber, Jörn Krätzschmar, Timour Prozorovski, Susan Pikol, Isabell Hamann, Judith Bellmann-Strobl, Orhan Aktas, Jan Dörr, Jens Wuerfel,…

  Source: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2005 Nov

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• Green tea epigallocatechin-3-gallate mediates T cellular NF-kappa B inhibition and exerts neuroprotection in autoimmune encephalomyelitis.

  Recent studies in multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE), point to the fact that even in the early p…

  Authors: Orhan Aktas, Timour Prozorovski, Alina Smorodchenko, Nicolai E Savaskan, Roland Lauster, Peter-Michael Kloetzel, Carmen Infante-Duarte, Stefan Brocke, Frauke Zipp

  Source: Journal of immunology (Baltimore, Md. : 1950). 2004 Nov 1

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