1 to 10 of 12 literature results

• Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase.

  Hepatitis C virus (HCV) is a human pathogen affecting nearly 3% of the world's population. Chronic infections can lead to cirrhosis and liver cancer. …

  Authors: Timothy L Tellinghuisen, Joseph Marcotrigiano, Charles M Rice

  Source: Nature. 2005 May 19

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• Identification of residues required for RNA replication in domains II and III of the hepatitis C virus NS5A protein.

  The NS5A protein of hepatitis C virus (HCV) plays an important but undefined role in viral RNA replication. NS5A has been proposed to be a three-domai…

  Authors: Timothy L Tellinghuisen, Katie L Foss, Jason C Treadaway, Charles M Rice

  Source: Journal of virology. 2008 Feb

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• The NS5A protein of bovine viral diarrhea virus contains an essential zinc-binding site similar to that of the hepatitis C virus NS5A protein.

  The recent demonstration that the NS5A protein of hepatitis C virus (HCV) contains an unconventional zinc-binding site with the format Cx(17)CxCx(20)C…

  Authors: Timothy L Tellinghuisen, Matthew S Paulson, Charles M Rice

  Source: Journal of virology. 2006 Aug

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• Interaction between hepatitis C virus proteins and host cell factors.

  Since the discovery of the hepatitis C virus (HCV) as the causative agent of non-A, non-B hepatitis, significant effort has been devoted to understand…

  Authors: Timothy L Tellinghuisen, Charles M Rice

  Source: Current opinion in microbiology. 2002 Aug

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• Association of sindbis virus capsid protein with phospholipid membranes and the E2 glycoprotein: implications for alphavirus assembly.

  A late stage in assembly of alphaviruses within infected cells is thought to be directed by interactions between the nucleocapsid and the cytoplasmic …

  Authors: Thomas A Wilkinson, Timothy L Tellinghuisen, Richard J Kuhn, Carol Beth Post

  Source: Biochemistry. 2005 Mar 1

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• Studying hepatitis C virus: making the best of a bad virus.

  Authors: Timothy L Tellinghuisen, Matthew J Evans, Thomas von Hahn, Shihyun You, Charles M Rice

  Source: Journal of virology. 2007 Sep

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• Reverse transcription PCR-based sequence analysis of hepatitis C virus replicon RNA.

  Since the advent of efficient cell-culture methods for HCV replication and, more recently, infection, there has been a need to efficiently sequence th…

  Authors: Timothy L Tellinghuisen, Brett D Lindenbach

  Source: Methods in molecular biology (Clifton, N.J.). 2009

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• Regulation of hepatitis C virion production via phosphorylation of the NS5A protein.

  Hepatitis C virus (HCV) is a significant pathogen, infecting some 170 million people worldwide. Persistent virus infection often leads to cirrhosis an…

  Authors: Timothy L Tellinghuisen, Katie L Foss, Jason Treadaway

  Source: PLoS pathogens. 2008 Mar

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• Molecular and contextual markers of hepatitis C virus and drug abuse.

  The spread of hepatitis C virus (HCV) infection involves a complex interplay of social risks, and molecular factors of both virus and host. Injection …

  Authors: Paul Shapshak, Charurut Somboonwit, Lydia N Drumright, Simon D W Frost, Deborah Commins, Timothy L Tellinghuisen, William K Scott, Robert Duncan, Clyde McCoy, J Bryan Page,…

  Source: Molecular diagnosis & therapy. 2009

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• The NS5A protein of hepatitis C virus is a zinc metalloprotein.

  The NS5A protein of hepatitis C virus is believed to be an integral part of the viral replicase. Despite extensive investigation, the role of this pro…

  Authors: Timothy L Tellinghuisen, Joseph Marcotrigiano, Alexander E Gorbalenya, Charles M Rice

  Source: The Journal of biological chemistry. 2004 Nov 19

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