1 to 10 of 118 literature results

• Structural basis of integrin regulation and signaling.

  Integrins are cell adhesion molecules that mediate cell-cell, cell-extracellular matrix, and cell-pathogen interactions. They play critical roles for …

  Authors: Bing-Hao Luo, Christopher V Carman, Timothy A Springer

  Source: Annual review of immunology. 2007

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• Integrin inside-out signaling and the immunological synapse.

  Integrins dynamically equilibrate between three conformational states on cell surfaces. A bent conformation has a closed headpiece. Two extended confo…

  Authors: Timothy A Springer, Michael L Dustin

  Source: Current opinion in cell biology. 2012 Feb

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• A mechanically stabilized receptor-ligand flex-bond important in the vasculature.

  Haemostasis in the arteriolar circulation mediated by von Willebrand factor (VWF) binding to platelets is an example of an adhesive interaction that m…

  Authors: Jongseong Kim, Cheng-Zhong Zhang, Xiaohui Zhang, Timothy A Springer

  Source: Nature. 2010 Aug 19

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• Latent TGF-β structure and activation.

  Transforming growth factor (TGF)-β is stored in the extracellular matrix as a latent complex with its prodomain. Activation of TGF-β1 requires the bin…

  Authors: Minlong Shi, Jianghai Zhu, Rui Wang, Xing Chen, Lizhi Mi, Thomas Walz, Timothy A Springer

  Source: Nature. 2011 Jun 16

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• Trans-cellular migration: cell-cell contacts get intimate.

  Trans-cellular migration, the movement of one cell directly through another, seems an unlikely, counterintuitive, and even bizarre process. Trans-cell…

  Authors: Christopher V Carman, Timothy A Springer

  Source: Current opinion in cell biology. 2008 Oct

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• Remodeling of the lectin-EGF-like domain interface in P- and L-selectin increases adhesiveness and shear resistance under hydrodynamic force.

  Crystal structures of the lectin and epidermal growth factor (EGF)-like domains of P-selectin show 'bent' and 'extended' conformations. An extended co…

  Authors: Uyen T Phan, Travis T Waldron, Timothy A Springer

  Source: Nature immunology. 2006 Aug

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• Integrin structures and conformational signaling.

  Integrins are cell adhesion molecules that play critical roles in development, wound healing, hemostasis, immunity and cancer. Advances in the past tw…

  Authors: Bing-Hao Luo, Timothy A Springer

  Source: Current opinion in cell biology. 2006 Oct

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• The structure of a receptor with two associating transmembrane domains on the cell surface: integrin alphaIIbbeta3.

  Structures of intact receptors with single-pass transmembrane domains are essential to understand how extracellular and cytoplasmic domains regulate a…

  Authors: Jieqing Zhu, Bing-Hao Luo, Patrick Barth, Jack Schonbrun, David Baker, Timothy A Springer

  Source: Molecular cell. 2009 Apr 24

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• César Milstein, the father of modern immunology.

  Authors: Timothy A Springer

  Source: Nature immunology. 2002 Jun

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• Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces.

  The complete ectodomain of integrin alpha(IIb)beta(3) reveals a bent, closed, low-affinity conformation, the beta knee, and a mechanism for linking cy…

  Authors: Jianghai Zhu, Bing-Hao Luo, Tsan Xiao, Chengzhong Zhang, Noritaka Nishida, Timothy A Springer

  Source: Molecular cell. 2008 Dec 26

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