1 to 10 of 15 literature results

• Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry.

  Hepatitis C virus (HCV) is a leading cause of cirrhosis and liver cancer worldwide. A better understanding of the viral life cycle, including the mech…

  Authors: Matthew J Evans, Thomas von Hahn, Donna M Tscherne, Andrew J Syder, Maryline Panis, Benno Wölk, Theodora Hatziioannou, Jane A McKeating, Paul D Bieniasz, Charles M Rice

  Source: Nature. 2007 Apr 12

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• Hepatitis C virus continuously escapes from neutralizing antibody and T-cell responses during chronic infection in vivo.

  BACKGROUND & AIMS: Broadly reactive neutralizing antibodies (nAbs) and multispecific T-cell responses are generated during chronic hepatitis C virus (…

  Authors: Thomas von Hahn, Joo Chun Yoon, Harvey Alter, Charles M Rice, Barbara Rehermann, Peter Balfe, Jane A McKeating

  Source: Gastroenterology. 2007 Feb

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• Mutations in hepatitis C virus E2 located outside the CD81 binding sites lead to escape from broadly neutralizing antibodies but compromise virus infectivity.

  Broadly neutralizing antibodies are commonly present in the sera of patients with chronic hepatitis C virus (HCV) infection. To elucidate possible mec…

  Authors: Zhen-yong Keck, Sophia H Li, Jinming Xia, Thomas von Hahn, Peter Balfe, Jane A McKeating, Jeroen Witteveldt, Arvind H Patel, Harvey Alter, Charles M Rice,…

  Source: Journal of virology. 2009 Jun

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• Superinfection exclusion in cells infected with hepatitis C virus.

  Superinfection exclusion is the ability of an established virus infection to interfere with infection by a second virus. In this study, we found that …

  Authors: Donna M Tscherne, Matthew J Evans, Thomas von Hahn, Christopher T Jones, Zania Stamataki, Jane A McKeating, Brett D Lindenbach, Charles M Rice

  Source: Journal of virology. 2007 Apr

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• Diverse CD81 proteins support hepatitis C virus infection.

  Hepatitis C virus (HCV) entry is dependent on CD81. To investigate whether the CD81 sequence is a determinant of HCV host range, we expressed a panel …

  Authors: Mike Flint, Thomas von Hahn, Jie Zhang, Michelle Farquhar, Christopher T Jones, Peter Balfe, Charles M Rice, Jane A McKeating

  Source: Journal of virology. 2006 Nov

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• High-avidity monoclonal antibodies against the human scavenger class B type I receptor efficiently block hepatitis C virus infection in the presence of high-density lipoprotein.

  The human scavenger class B type 1 receptor (SR-B1/Cla1) was identified as a putative receptor for hepatitis C virus (HCV) because it binds to soluble…

  Authors: Maria Teresa Catanese, Rita Graziani, Thomas von Hahn, Martine Moreau, Thierry Huby, Giacomo Paonessa, Claudia Santini, Alessandra Luzzago, Charles M Rice, Riccardo Cortese,…

  Source: Journal of virology. 2007 Aug

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• In vitro veritas? The challenges of studying hepatitis C virus infectivity in a test tube.

  Authors: Thomas von Hahn, Jane A McKeating

  Source: Journal of hepatology. 2007 Mar

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• Relevance of endotoxin receptor CD14 and TLR4 gene variants in chronic liver disease.

  OBJECTIVE: The lipopolysaccharide (LPS)-triggered release of inflammatory cytokines from Kupffer cells is mediated via the CD14/TLR4 receptor complex.…

  Authors: Thomas Von Hahn, Juliane Halangk, Heiko Witt, Konrad Neumann, Tobias Müller, Gero Puhl, Peter Neuhaus, Renate Nickel, Ulrich Beuers, Bertram Wiedenmann,…

  Source: Scandinavian journal of gastroenterology. 2008

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• Know your enemy: translating insights about the molecular biology of hepatitis C virus into novel therapeutic approaches.

  Identified in 1989 as the cause of what was then known as hepatitis non-A non-B, the hepatitis C virus (HCV) continues to be a significant global publ…

  Authors: Thomas von Hahn, Eike Steinmann, Sandra Ciesek, Thomas Pietschmann

  Source: Expert review of gastroenterology & hepatology. 2010 Feb

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• Studying hepatitis C virus: making the best of a bad virus.

  Authors: Timothy L Tellinghuisen, Matthew J Evans, Thomas von Hahn, Shihyun You, Charles M Rice

  Source: Journal of virology. 2007 Sep

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