1 to 10 of 59 literature results

• Large recurrent microdeletions associated with schizophrenia.

  Reduced fecundity, associated with severe mental disorders, places negative selection pressure on risk alleles and may explain, in part, why common va…

  Authors: Hreinn Stefansson, Dan Rujescu, Sven Cichon, Olli P H Pietiläinen, Andres Ingason, Stacy Steinberg, Ragnheidur Fossdal, Engilbert Sigurdsson, Thordur Sigmundsson, Jacobine E Buizer-Voskamp,…

  Source: Nature. 2008 Sep 11

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• Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.

  Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation of inflammatory responses and thus have important roles …

  Authors: Daniel F Gudbjartsson, Unnur S Bjornsdottir, Eva Halapi, Anna Helgadottir, Patrick Sulem, Gudrun M Jonsdottir, Gudmar Thorleifsson, Hafdis Helgadottir, Valgerdur Steinthorsdottir, Hreinn Stefansson,…

  Source: Nature genetics. 2009 Mar

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• Common variants conferring risk of schizophrenia.

  Schizophrenia is a complex disorder, caused by both genetic and environmental factors and their interactions. Research on pathogenesis has traditional…

  Authors: Hreinn Stefansson, Roel A Ophoff, Stacy Steinberg, Ole A Andreassen, Sven Cichon, Dan Rujescu, Thomas Werge, Olli P H Pietiläinen, Ole Mors, Preben B Mortensen,…

  Source: Nature. 2009 Aug 6

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• Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene.

  Oxidative stress could be involved in the pathophysiology of schizophrenia, a major psychiatric disorder. Glutathione (GSH), a redox regulator, is dec…

  Authors: Mirjana Tosic, Jurg Ott, Sandra Barral, Pierre Bovet, Patricia Deppen, Fulvia Gheorghita, Marie-Louise Matthey, Josef Parnas, Martin Preisig, Michael Saraga,…

  Source: American journal of human genetics. 2006 Sep

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• A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia.

  The Abelson helper integration site 1 (AHI1) gene locus on chromosome 6q23 is among a group of candidate loci for schizophrenia susceptibility that we…

  Authors: Andrés Ingason, Ina Giegling, Sven Cichon, Thomas Hansen, Henrik B Rasmussen, Jimmi Nielsen, Gesche Jürgens, Pierandrea Muglia, Annette M Hartmann, Eric Strengman,…

  Source: Human molecular genetics. 2010 Jan 12

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• Evidence for a possible association of neurotrophin receptor (NTRK-3) gene polymorphisms with hippocampal function and schizophrenia.

  Altered neurodevelopment and plasticity are implicated in schizophrenia pathology. Based on the important role of neurotrophic factors in brain develo…

  Authors: Mona K Otnaess, Srdjan Djurovic, Lars M Rimol, Bettina Kulle, Anna K Kähler, Erik G Jönsson, Ingrid Agartz, Kjetil Sundet, Håkan Hall, Sally Timm,…

  Source: Neurobiology of disease. 2009 Jun

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• Antidepressive-drug-induced bodyweight gain is associated with polymorphisms in genes coding for COMT and TPH1.

  Bodyweight gain is a common side effect of treatment with antidepressive drugs; however, little is known about the mechanisms behind this weight gain.…

  Authors: Anna Secher, Jens Bukh, Camilla Bock, Pernille Koefoed, Henrik Berg Rasmussen, Thomas Werge, Lars Vedel Kessing, Erling Mellerup

  Source: International clinical psychopharmacology. 2009 Jul

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• Association between a disrupted-in-schizophrenia 1 (DISC1) single nucleotide polymorphism and schizophrenia in a combined Scandinavian case-control sample.

  Disrupted-in-schizophrenia-1 (DISC1), located on chromosome 1q42.1, is linked to rare familial schizophrenia in a large Scottish family. The chromosom…

  Authors: Peter Saetre, Ingrid Agartz, Alessandra De Franciscis, Per Lundmark, Srdjan Djurovic, Anna Kähler, Ole A Andreassen, Klaus D Jakobsen, Henrik B Rasmussen, Thomas Werge,…

  Source: Schizophrenia research. 2008 Dec

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• Mutation screening of the glutamate cysteine ligase modifier (GCLM) gene in patients with schizophrenia.

  BACKGROUND: Experimental evidences show that glutathione and its rate-limiting synthesizing enzyme, the glutamate-cysteine ligase (GCL), are involved …

  Authors: Christophe Butticaz, Thomas Werge, Jacques S Beckmann, Michel Cuénod, Kim Q Do, Carlo Rivolta

  Source: Psychiatric genetics. 2009 Aug

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• Disruption of the neurexin 1 gene is associated with schizophrenia.

  Deletions within the neurexin 1 gene (NRXN1; 2p16.3) are associated with autism and have also been reported in two families with schizophrenia. We exa…

  Authors: Dan Rujescu, Andres Ingason, Sven Cichon, Olli P H Pietiläinen, Michael R Barnes, Timothea Toulopoulou, Marco Picchioni, Evangelos Vassos, Ulrich Ettinger, Elvira Bramon,…

  Source: Human molecular genetics. 2009 Mar 1

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