1 to 10 of 116 literature results

• SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin.

  The Sir2 deacetylase regulates chromatin silencing and lifespan in Saccharomyces cerevisiae. In mice, deficiency for the Sir2 family member SIRT6 lead…

  Authors: Eriko Michishita, Ronald A McCord, Elisabeth Berber, Mitomu Kioi, Hesed Padilla-Nash, Mara Damian, Peggie Cheung, Rika Kusumoto, Tiara L A Kawahara, J Carl Barrett,…

  Source: Nature. 2008 Mar 27

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• ATM prevents the persistence and propagation of chromosome breaks in lymphocytes.

  DNA double-strand breaks (DSBs) induce a signal transmitted by the ataxia-telangiectasia mutated (ATM) kinase, which suppresses illegitimate joining o…

  Authors: Elsa Callén, Mila Jankovic, Simone Difilippantonio, Jeremy A Daniel, Hua-Tang Chen, Arkady Celeste, Manuela Pellegrini, Kevin McBride, Danny Wangsa, Andrea L Bredemeyer,…

  Source: Cell. 2007 Jul 13

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• AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations.

  Cancer-initiating translocations such as those associated with lymphomas require the formation of paired DNA double-strand breaks (DSBs). Activation-i…

  Authors: Davide F Robbiani, Samuel Bunting, Niklas Feldhahn, Anne Bothmer, Jordi Camps, Stephanie Deroubaix, Kevin M McBride, Isaac A Klein, Gary Stone, Thomas R Eisenreich,…

  Source: Molecular cell. 2009 Nov 25

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• Positional stability of single double-strand breaks in mammalian cells.

  Formation of cancerous translocations requires the illegitimate joining of chromosomes containing double-strand breaks (DSBs). It is unknown how broke…

  Authors: Evi Soutoglou, Jonas F Dorn, Kundan Sengupta, Maria Jasin, Andre Nussenzweig, Thomas Ried, Gaudenz Danuser, Tom Misteli

  Source: Nature cell biology. 2007 Jun

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• The XIST noncoding RNA functions independently of BRCA1 in X inactivation.

  Females with germline mutations in BRCA1 are predisposed to develop breast and ovarian cancers. A previous report indicated that BRCA1 colocalizes wit…

  Authors: Cuiying Xiao, Judith A Sharp, Misako Kawahara, Albert R Davalos, Michael J Difilippantonio, Ying Hu, Wenmei Li, Liu Cao, Ken Buetow, Thomas Ried,…

  Source: Cell. 2007 Mar 9

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• Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice.

  In lower eukaryotes, Sir2 serves as a histone deacetylase and is implicated in chromatin silencing, longevity, and genome stability. Here we mutated t…

  Authors: Rui-Hong Wang, Kundan Sengupta, Cuiling Li, Hyun-Seok Kim, Liu Cao, Cuiying Xiao, Sangsoo Kim, Xiaoling Xu, Yin Zheng, Beverly Chilton,…

  Source: Cancer cell. 2008 Oct 7

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• H2AX haploinsufficiency modifies genomic stability and tumor susceptibility.

  Histone H2AX becomes phosphorylated in chromatin domains flanking sites of DNA double-strand breakage associated with gamma-irradiation, meiotic recom…

  Authors: Arkady Celeste, Simone Difilippantonio, Michael J Difilippantonio, Oscar Fernandez-Capetillo, Duane R Pilch, Olga A Sedelnikova, Michael Eckhaus, Thomas Ried, William M Bonner, André Nussenzweig

  Source: Cell. 2003 Aug 8

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• Beta-catenin expression results in p53-independent DNA damage and oncogene-induced senescence in prelymphomagenic thymocytes in vivo.

  The expression of beta-catenin, a potent oncogene, is causally linked to tumorigenesis. Therefore, it was surprising that the transgenic expression of…

  Authors: Mai Xu, Qing Yu, Ramesh Subrahmanyam, Michael J Difilippantonio, Thomas Ried, Jyoti Misra Sen

  Source: Molecular and cellular biology. 2008 Mar

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• From silencing to gene expression: real-time analysis in single cells.

  We have developed an inducible system to visualize gene expression at the levels of DNA, RNA and protein in living cells. The system is composed of a …

  Authors: Susan M Janicki, Toshiro Tsukamoto, Simone E Salghetti, William P Tansey, Ravi Sachidanandam, Kannanganattu V Prasanth, Thomas Ried, Yaron Shav-Tal, Edouard Bertrand, Robert H Singer,…

  Source: Cell. 2004 Mar 5

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• Cisplatin depletes TREX2 and causes Robertsonian translocations as seen in TREX2 knockout cells.

  Cisplatin, an anticancer drug, forms DNA interstrand cross-links (ICL) that interfere with replication, whereas TREX2 is a 3'-->5' exonuclease that re…

  Authors: Ming-Jiu Chen, Lavinia C Dumitrache, Danny Wangsa, Sheng-Mei Ma, Hesed Padilla-Nash, Thomas Ried, Paul Hasty

  Source: Cancer research. 2007 Oct 1

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