Click on one of these terms to refine your search
1 to 10 of 116 literature results
The Sir2 deacetylase regulates chromatin silencing and lifespan in Saccharomyces cerevisiae. In mice, deficiency for the Sir2 family member SIRT6 lead…
Authors: Eriko Michishita, Ronald A McCord, Elisabeth Berber, Mitomu Kioi, Hesed Padilla-Nash, Mara Damian, Peggie Cheung, Rika Kusumoto, Tiara L A Kawahara, J Carl Barrett,…
Source: Nature. 2008 Mar 27
View Free Full TextDNA double-strand breaks (DSBs) induce a signal transmitted by the ataxia-telangiectasia mutated (ATM) kinase, which suppresses illegitimate joining o…
Authors: Elsa Callén, Mila Jankovic, Simone Difilippantonio, Jeremy A Daniel, Hua-Tang Chen, Arkady Celeste, Manuela Pellegrini, Kevin McBride, Danny Wangsa, Andrea L Bredemeyer,…
Source: Cell. 2007 Jul 13
View Full TextCancer-initiating translocations such as those associated with lymphomas require the formation of paired DNA double-strand breaks (DSBs). Activation-i…
Authors: Davide F Robbiani, Samuel Bunting, Niklas Feldhahn, Anne Bothmer, Jordi Camps, Stephanie Deroubaix, Kevin M McBride, Isaac A Klein, Gary Stone, Thomas R Eisenreich,…
Source: Molecular cell. 2009 Nov 25
View Full TextFormation of cancerous translocations requires the illegitimate joining of chromosomes containing double-strand breaks (DSBs). It is unknown how broke…
Authors: Evi Soutoglou, Jonas F Dorn, Kundan Sengupta, Maria Jasin, Andre Nussenzweig, Thomas Ried, Gaudenz Danuser, Tom Misteli
Source: Nature cell biology. 2007 Jun
View Free Full TextFemales with germline mutations in BRCA1 are predisposed to develop breast and ovarian cancers. A previous report indicated that BRCA1 colocalizes wit…
Authors: Cuiying Xiao, Judith A Sharp, Misako Kawahara, Albert R Davalos, Michael J Difilippantonio, Ying Hu, Wenmei Li, Liu Cao, Ken Buetow, Thomas Ried,…
Source: Cell. 2007 Mar 9
View Full TextIn lower eukaryotes, Sir2 serves as a histone deacetylase and is implicated in chromatin silencing, longevity, and genome stability. Here we mutated t…
Authors: Rui-Hong Wang, Kundan Sengupta, Cuiling Li, Hyun-Seok Kim, Liu Cao, Cuiying Xiao, Sangsoo Kim, Xiaoling Xu, Yin Zheng, Beverly Chilton,…
Source: Cancer cell. 2008 Oct 7
View Free Full TextHistone H2AX becomes phosphorylated in chromatin domains flanking sites of DNA double-strand breakage associated with gamma-irradiation, meiotic recom…
Authors: Arkady Celeste, Simone Difilippantonio, Michael J Difilippantonio, Oscar Fernandez-Capetillo, Duane R Pilch, Olga A Sedelnikova, Michael Eckhaus, Thomas Ried, William M Bonner, André Nussenzweig
Source: Cell. 2003 Aug 8
View Full TextThe expression of beta-catenin, a potent oncogene, is causally linked to tumorigenesis. Therefore, it was surprising that the transgenic expression of…
Authors: Mai Xu, Qing Yu, Ramesh Subrahmanyam, Michael J Difilippantonio, Thomas Ried, Jyoti Misra Sen
Source: Molecular and cellular biology. 2008 Mar
View Free Full TextWe have developed an inducible system to visualize gene expression at the levels of DNA, RNA and protein in living cells. The system is composed of a …
Authors: Susan M Janicki, Toshiro Tsukamoto, Simone E Salghetti, William P Tansey, Ravi Sachidanandam, Kannanganattu V Prasanth, Thomas Ried, Yaron Shav-Tal, Edouard Bertrand, Robert H Singer,…
Source: Cell. 2004 Mar 5
View Full TextCisplatin, an anticancer drug, forms DNA interstrand cross-links (ICL) that interfere with replication, whereas TREX2 is a 3'-->5' exonuclease that re…
Authors: Ming-Jiu Chen, Lavinia C Dumitrache, Danny Wangsa, Sheng-Mei Ma, Hesed Padilla-Nash, Thomas Ried, Paul Hasty
Source: Cancer research. 2007 Oct 1
View Full Text