1 to 10 of 19 literature results

• Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance.

  Chronic infection with hepatitis C virus (HCV) affects 170 million people worldwide and is the leading cause of cirrhosis in North America. Although t…

  Authors: Dongliang Ge, Jacques Fellay, Alexander J Thompson, Jason S Simon, Kevin V Shianna, Thomas J Urban, Erin L Heinzen, Ping Qiu, Arthur H Bertelsen, Andrew J Muir,…

  Source: Nature. 2009 Sep 17

  View Full Text

• ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C.

  Chronic infection with the hepatitis C virus (HCV) affects 170 million people worldwide and is an important cause of liver-related morbidity and morta…

  Authors: Jacques Fellay, Alexander J Thompson, Dongliang Ge, Curtis E Gumbs, Thomas J Urban, Kevin V Shianna, Latasha D Little, Ping Qiu, Arthur H Bertelsen, Mark Watson,…

  Source: Nature. 2010 Mar 18

  View Full Text

• WGAViewer: software for genomic annotation of whole genome association studies.

  To meet the immediate need for a framework of post-whole genome association (WGA) annotation, we have developed WGAViewer, a suite of JAVA software to…

  Authors: Dongliang Ge, Kunlin Zhang, Anna C Need, Olivier Martin, Jacques Fellay, Thomas J Urban, Amalio Telenti, David B Goldstein

  Source: Genome research. 2008 Apr

  View Free Full Text

• CCL3L1 and HIV/AIDS susceptibility.

  Authors: Thomas J Urban, Amy C Weintrob, Jacques Fellay, Sara Colombo, Kevin V Shianna, Curtis Gumbs, Margalida Rotger, Kimberly Pelak, Kristen K Dang, Roger Detels,…

  Source: Nature medicine. 2009 Oct

  View Full Text

• Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP.

  The second messenger, cGMP, mediates a host of cellular responses to various stimuli, resulting in the regulation of many critical physiologic functio…

  Authors: Cheryl D Cropp, Takafumi Komori, James E Shima, Thomas J Urban, Sook Wah Yee, Swati S More, Kathleen M Giacomini

  Source: Molecular pharmacology. 2008 Apr

  View Free Full Text

• Functional genomics of membrane transporters in human populations.

  Although considerable progress has been made toward characterizing human DNA sequence variation, there remains a deficiency in information on human ph…

  Authors: Thomas J Urban, Ronnie Sebro, Evan H Hurowitz, Maya K Leabman, Ilaria Badagnani, Leah L Lagpacan, Neil Risch, Kathleen M Giacomini

  Source: Genome research. 2006 Feb

  View Free Full Text

• PharmGKB submission update: V. PMT submissions of genetic variation in SLC22 family transporters.

  Authors: Yan Shu, Thomas J Urban, Maya K Leabman, Tomoe Fujita, Andrew R Erdman, Leah L Lagpacan, Chaline Brown, Richard A Castro, Conrad C Huang, Doug Stryke,…

  Source: Pharmacological reviews. 2006 Mar

  View Full Text

• The organic cation transporter, OCTN1, expressed in the human heart, potentiates antagonism of the HERG potassium channel.

  BACKGROUND: Variable function and expression of drug transporters have been proposed as mechanisms contributing to variable response to drug therapy. …

  Authors: Brian F McBride, Tao Yang, Kai Liu, Thomas J Urban, Kathleen M Giacomini, Richard B Kim, Dan M Roden

  Source: Journal of cardiovascular pharmacology. 2009 Jul

  View Full Text

• Functional genetic diversity in the high-affinity carnitine transporter OCTN2 (SLC22A5).

  Systemic carnitine deficiency (SCD) is a rare autosomal recessive disease resulting from defects in the OCTN2 (SLC22A5) gene, which encodes the high-a…

  Authors: Thomas J Urban, Renata C Gallagher, Chaline Brown, Richard A Castro, Leah L Lagpacan, Claire M Brett, Travis R Taylor, Elaine J Carlson, Thomas E Ferrin, Esteban G Burchard,…

  Source: Molecular pharmacology. 2006 Nov

  View Full Text

• Functional and genetic diversity in the concentrative nucleoside transporter, CNT1, in human populations.

  The concentrative nucleoside transporter, CNT1 (SLC28A1), mediates the cellular uptake of naturally occurring pyrimidine nucleosides and many structur…

  Authors: Jennifer H Gray, Lara M Mangravite, Ryan P Owen, Thomas J Urban, Wendy Chan, Elaine J Carlson, Conrad C Huang, Michiko Kawamoto, Susan J Johns, Douglas Stryke,…

  Source: Molecular pharmacology. 2004 Mar

  View Full Text