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Comparative genomic and phylogeographic analysis of Mycobacterium leprae.
Reductive evolution and massive pseudogene formation have shaped the 3.31-Mb genome of Mycobacterium leprae, an unculturable obligate pathogen that ca…
Authors: Marc Monot, Nadine Honoré, Thierry Garnier, Nora Zidane, Diana Sherafi, Alberto Paniz-Mondolfi, Masanori Matsuoka, G Michael Taylor, Helen D Donoghue, Abi Bouwman,…
Source: Nature genetics. 2009 Dec
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Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer.
Mycobacterium ulcerans is found in aquatic ecosystems and causes Buruli ulcer in humans, a neglected but devastating necrotic disease of subcutaneous …
Authors: Timothy P Stinear, Torsten Seemann, Sacha Pidot, Wafa Frigui, Gilles Reysset, Thierry Garnier, Guillaume Meurice, David Simon, Christiane Bouchier, Laurence Ma,…
Source: Genome research. 2007 Feb
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Differential effects of prior exposure to environmental mycobacteria on vaccination with Mycobacterium bovis BCG or a recombinant BCG strain expressing RD1 antigens.
In silico analysis reveals that most protective antigens expressed by the antituberculous vaccine Mycobacterium bovis BCG (BCG) are conserved in M. av…
Authors: Caroline Demangel, Thierry Garnier, Ida Rosenkrands, Stewart T Cole
Source: Infection and immunity. 2005 Apr
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A comprehensive survey of single nucleotide polymorphisms (SNPs) across Mycobacterium bovis strains and M. bovis BCG vaccine strains refines the genealogy and defines a minimal set of SNPs that separate virulent M. bovis strains and M. bovis BCG strains.
To further unravel the mechanisms responsible for attenuation of the tuberculosis vaccine Mycobacterium bovis BCG, comparative genomics was used to id…
Authors: M Carmen Garcia Pelayo, Swapna Uplekar, Andrew Keniry, Pablo Mendoza Lopez, Thierry Garnier, Javier Nunez Garcia, Laura Boschiroli, Xiangmei Zhou, Julian Parkhill, Noel Smith,…
Source: Infection and immunity. 2009 May
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Common evolutionary origin for the unstable virulence plasmid pMUM found in geographically diverse strains of Mycobacterium ulcerans.
The 174-kb virulence plasmid pMUM001 in Mycobacterium ulcerans epidemic strain Agy99 harbors three very large and homologous genes that encode giant p…
Authors: Timothy P Stinear, Hui Hong, Wafa Frigui, Melinda J Pryor, Roland Brosch, Thierry Garnier, Peter F Leadlay, Stewart T Cole
Source: Journal of bacteriology. 2005 Mar
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Spread of injectate associated with radial or median nerve-type motor response during infraclavicular brachial-plexus block: an ultrasound evaluation.
BACKGROUND AND OBJECTIVES: We have compared ultrasound characteristics of spread during infraclavicular brachial-plexus blocks by use of electrically …
Authors: Sébastien Bloc, Thierry Garnier, Bernard Komly, Hugues Asfazadourian, Pascal Leclerc, Luc Mercadal, Bertrand Morel, Gilles Dhonneur
Source: Regional anesthesia and pain medicine. 2007 Mar-Apr
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Single-stimulation, low-volume infraclavicular plexus block: influence of the evoked distal motor response on success rate.
BACKGROUND AND OBJECTIVES: We compared the success rate of single-injection infraclavicular plexus block by using electrically evoked radial, ulnar, o…
Authors: Sébastien Bloc, Thierry Garnier, Bernard Komly, Pascal Leclerc, Luc Mercadal, Bertrand Morel, Gilles Dhonneur
Source: Regional anesthesia and pain medicine. 2006 Sep-Oct
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Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant.
Mycobacterium microti is a member of the Mycobacterium tuberculosis complex that causes tuberculosis in voles. Most strains of M. microti are harmless…
Authors: Priscille Brodin, Karin Eiglmeier, Magali Marmiesse, Alain Billault, Thierry Garnier, Stefan Niemann, Stewart T Cole, Roland Brosch
Source: Infection and immunity. 2002 Oct
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Royal Society of Tropical Medicine and Hygiene Meeting at Manson House, London, 18th January 2001. Pathogen genomes and human health. Mycobacterial genomics.
The small size of their genomes made bacterial ideal model organisms for the emerging field of genomics. Elucidating the genome sequences of mycobacte…
Authors: Stephen V Gordon, Roland Brosch, Karin Eiglmeier, Thierry Garnier, R Glyn Hewinson, Stewart T Cole
Source: Transactions of the Royal Society of Tropical Medicine and Hygiene. 2002 Jan-Feb
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Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP.
Analysis of mycobacterial strains that have lost their ability to cause disease is a powerful approach to identify yet unknown virulence determinants …
Authors: Wafa Frigui, Daria Bottai, Laleh Majlessi, Marc Monot, Emmanuelle Josselin, Priscille Brodin, Thierry Garnier, Brigitte Gicquel, Carlos Martin, Claude Leclerc,…
Source: PLoS pathogens. 2008 Feb 8
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