10 literature results

• Human tumor-specific T lymphocytes: does function matter more than number?

  In recent years, several clinical trials have involved the vaccination of cancer patients with tumor-specific antigens that are recognized by T lympho…

  Authors: Pierre G Coulie, Thierry Connerotte

  Source: Current opinion in immunology. 2005 Jun

  View Full Text

• Functions of Anti-MAGE T-cells induced in melanoma patients under different vaccination modalities.

  Tumor regressions have been observed in a small proportion of melanoma patients vaccinated with a MAGE-A3 peptide presented by HLA-A1, administered as…

  Authors: Thierry Connerotte, Aline Van Pel, Danièle Godelaine, Eric Tartour, Beatrice Schuler-Thurner, Sophie Lucas, Kris Thielemans, Gerold Schuler, Pierre G Coulie

  Source: Cancer research. 2008 May 15

  View Full Text

• Comparison of stable human Treg and Th clones by transcriptional profiling.

  From cancerous and non-cancerous patients, we derived stable clones of CD4(+) Treg, defined as clones that expressed high CD25 at rest, were anergic i…

  Authors: Julie Stockis, Wolfram Fink, Violaine François, Thierry Connerotte, Charles de Smet, Laurent Knoops, Pierre van der Bruggen, Thierry Boon, Pierre G Coulie, Sophie Lucas

  Source: European journal of immunology. 2009 Mar

  View Full Text

• Impaired up-regulation of polo-like kinase 2 in B-cell chronic lymphocytic leukaemia lymphocytes resistant to fludarabine and 2-chlorodeoxyadenosine: a potential marker of defective damage response.

  The functional evaluation of ataxia telangiectasia mutated (ATM) and p53 was recently developed in B-cell chronic lymphocytic leukaemia (B-CLL), a dis…

  Authors: Emeline de Viron, Laurent Knoops, Thierry Connerotte, Caroline Smal, Lucienne Michaux, Pascale Saussoy, Pascal Vannuffel, Eline Beert, Marie-Christiane Vekemans, Cédric Hermans,…

  Source: British journal of haematology. 2009 Dec

  View Full Text

• Cytolytic T-cell responses of cancer patients vaccinated with a MAGE antigen.

  Cancer-germline' genes such as the MAGE gene family are expressed in many tumors and in male germline cells but not in normal tissues. They encode sha…

  Authors: Pierre G Coulie, Vaios Karanikas, Christophe Lurquin, Didier Colau, Thierry Connerotte, Takeshi Hanagiri, Aline Van Pel, Sophie Lucas, Danièle Godelaine, Christophe Lonchay,…

  Source: Immunological reviews. 2002 Oct

  View Full Text

• Dominant TCR V alpha usage by virus and tumor-reactive T cells with wide affinity ranges for their specific antigens.

  We have studied the TCR features and functional responses of three sets of human cytolytic T cell (CTL) clones, recognizing antigenic peptides present…

  Authors: Lydie Trautmann, Nathalie Labarrière, Francine Jotereau, Vaios Karanikas, Nadine Gervois, Thierry Connerotte, Pierre Coulie, Marc Bonneville

  Source: European journal of immunology. 2002 Nov

  View Full Text

• Use of 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography in the early diagnosis of asymptomatic bleomycin-induced pneumonitis.

  Authors: Thierry Connerotte, Max Lonneux, Yves de Meeûs, Cédric Hermans, Marie-Christiane Vekemans, Augustin Ferrant, Eric Van Den Neste

  Source: Annals of hematology. 2008 Nov

  View Full Text

• Correlation between tumor regression and T cell responses in melanoma patients vaccinated with a MAGE antigen.

  The cancer-germline gene MAGE-3 codes for tumor-specific antigens recognized on many tumors by T lymphocytes. A MAGE-3 antigen presented by HLA-A1 has…

  Authors: Christophe Lonchay, Pierre van der Bruggen, Thierry Connerotte, Takeshi Hanagiri, Pierre Coulie, Didier Colau, Sophie Lucas, Aline Van Pel, Kris Thielemans, Nicolas van Baren,…

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2004 Oct 5

  View Free Full Text

• Monoclonal anti-MAGE-3 CTL responses in melanoma patients displaying tumor regression after vaccination with a recombinant canarypox virus.

  We have analyzed the T cell responses of HLA-A1 metastatic melanoma patients with detectable disease, following vaccination with a recombinant ALVAC v…

  Authors: Vaios Karanikas, Christophe Lurquin, Didier Colau, Nicolas van Baren, Charles De Smet, Bernard Lethé, Thierry Connerotte, Véronique Corbière, Marie-Ange Demoitié, Danielle Liénard,…

  Source: Journal of immunology (Baltimore, Md. : 1950). 2003 Nov 1

  View Full Text

• Prevalent role of TCR alpha-chain in the selection of the preimmune repertoire specific for a human tumor-associated self-antigen.

  The specificity of recognition of pMHC complexes by T lymphocytes is determined by the V regions of the TCR alpha- and beta-chains. Recent experimenta…

  Authors: Pierre-Yves Dietrich, Frédérique-Anne Le Gal, Valérie Dutoit, Mikäel J Pittet, Lydie Trautman, Alfred Zippelius, Isabelle Cognet, Valérie Widmer, Paul R Walker, Olivier Michielin,…

  Source: Journal of immunology (Baltimore, Md. : 1950). 2003 May 15

  View Full Text