1 to 10 of 12 literature results

• A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses.

  The family of mammalian Nod-like receptors (NLRs) consists of critical intracellular immune proteins structurally related to plant resistance proteins…

  Authors: Annick Mayor, Fabio Martinon, Thibaut De Smedt, Virginie Pétrilli, Jürg Tschopp

  Source: Nature immunology. 2007 May

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• Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner.

  Tumor necrosis factor (TNF) synthesis is known to play a major part in numerous inflammatory disorders, and multiple transcriptional and post-transcri…

  Authors: Frédéric Van Gool, Mara Gallí, Cyril Gueydan, Véronique Kruys, Pierre-Paul Prevot, Antonio Bedalov, Raul Mostoslavsky, Frederick W Alt, Thibaut De Smedt, Oberdan Leo

  Source: Nature medicine. 2009 Feb

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• Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice.

  The cytokine thymic stromal lymphopoietin (TSLP) has been linked to human allergic inflammatory diseases. We show here that TSLP expression was increa…

  Authors: Baohua Zhou, Michael R Comeau, Thibaut De Smedt, H Denny Liggitt, Martin E Dahl, David B Lewis, Dora Gyarmati, Theingi Aye, Daniel J Campbell, Steven F Ziegler

  Source: Nature immunology. 2005 Oct

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• A pilot study of IL-1 inhibition by anakinra in acute gout.

  Monosodium urate crystals stimulate monocytes and macrophages to release IL-1beta through the NALP3 component of the inflammasome. The effectiveness o…

  Authors: Alexander So, Thibaut De Smedt, Sylvie Revaz, Jürg Tschopp

  Source: Arthritis research & therapy. 2007

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• Poxvirus semaphorin A39R inhibits phagocytosis by dendritic cells and neutrophils.

  The poxvirus A39R protein is a member of the semaphorin family that binds to Plexin C1, a molecule expressed on neutrophils and dendritic cells (DC). …

  Authors: Thierry Walzer, Laurent Galibert, Thibaut De Smedt

  Source: European journal of immunology. 2005 Feb

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• Dendritic cell function in mice lacking Plexin C1.

  Semaphorins are secreted or transmembrane proteins that provide essential repulsive guidance cues to growing axons or endothelial cells through their …

  Authors: Thierry Walzer, Laurent Galibert, Thibaut De Smedt

  Source: International immunology. 2005 Jul

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• Pharmacological inhibition of nicotinamide phosphoribosyltransferase/visfatin enzymatic activity identifies a new inflammatory pathway linked to NAD.

  Nicotinamide phosphoribosyltransferase (NAMPT), also known as visfatin, is the rate-limiting enzyme in the salvage pathway of NAD biosynthesis from ni…

  Authors: Nathalie Busso, Mahir Karababa, Massimo Nobile, Aline Rolaz, Frédéric Van Gool, Mara Galli, Oberdan Leo, Alexander So, Thibaut De Smedt

  Source: PloS one. 2008

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• Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome.

  Adjuvants are vaccine additives that stimulate the immune system without having any specific antigenic effect of itself. In this study we show that al…

  Authors: Mirjam Kool, Virginie Pétrilli, Thibaut De Smedt, Aline Rolaz, Hamida Hammad, Menno van Nimwegen, Ingrid M Bergen, Rosa Castillo, Bart N Lambrecht, Jürg Tschopp

  Source: Journal of immunology (Baltimore, Md. : 1950). 2008 Sep 15

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• Plexin C1 engagement on mouse dendritic cells by viral semaphorin A39R induces actin cytoskeleton rearrangement and inhibits integrin-mediated adhesion and chemokine-induced migration.

  The poxvirus A39R protein is a member of the semaphorin family previously reported to bind plexin C1. We show that, in the mouse, plexin C1 is express…

  Authors: Thierry Walzer, Laurent Galibert, Michael R Comeau, Thibaut De Smedt

  Source: Journal of immunology (Baltimore, Md. : 1950). 2005 Jan 1

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• No defect in T-cell priming, secondary response, or tolerance induction in response to inhaled antigens in Fms-like tyrosine kinase 3 ligand-deficient mice.

  BACKGROUND: Respiratory tract dendritic cells (DCs) are crucial for the regulation of immune responses to inhaled antigens. However, the precise funct…

  Authors: Thierry Walzer, Pierre Brawand, David Swart, Joel Tocker, Thibaut De Smedt

  Source: The Journal of allergy and clinical immunology. 2005 Jan

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