1 to 10 of 42 literature results

• Hepatic insulin resistance directly promotes formation of cholesterol gallstones.

  Despite the well-documented association between gallstones and the metabolic syndrome, the mechanistic links between these two disorders remain unknow…

  Authors: Sudha B Biddinger, Joel T Haas, Bian B Yu, Olivier Bezy, Enxuan Jing, Wenwei Zhang, Terry G Unterman, Martin C Carey, C Ronald Kahn

  Source: Nature medicine. 2008 Jul

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• FOXO transcription factors and VEGF neutralizing antibody enhance antiangiogenic effects of resveratrol.

  Resveratrol (trans-3,5,4'-trihydroxystilbene), a compound found largely in the skins of red grapes and wines, possesses anti-cancer and anti-angiogeni…

  Authors: Rakesh K Srivastava, Terry G Unterman, Sharmila Shankar

  Source: Molecular and cellular biochemistry. 2010 Apr

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• Forkhead box protein O1 negatively regulates skeletal myocyte differentiation through degradation of mammalian target of rapamycin pathway components.

  The forkhead transcription factor forkhead box protein O1 (FoxO1), a downstream target of phosphatidylinositol 3-kinase/Akt signaling, has been report…

  Authors: Ai-Luen Wu, Jeong-Ho Kim, Chongben Zhang, Terry G Unterman, Jie Chen

  Source: Endocrinology. 2008 Mar

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• Insulin response sequence-dependent and -independent mechanisms mediate effects of insulin on glucocorticoid-stimulated insulin-like growth factor binding protein-1 promoter activity.

  IGF binding protein-1 (IGFBP-1) gene expression is stimulated by glucocorticoids and suppressed by insulin in the liver. Insulin response sequences (I…

  Authors: Lixia Gan, Haiyun Pan, Terry G Unterman

  Source: Endocrinology. 2005 Oct

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• Protein kinase B-alpha inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors.

  Starvation and diabetes increase pyruvate dehydrogenase kinase-4 (PDK4) expression, which conserves gluconeogenic substrates by inactivating the pyruv…

  Authors: Hye-Sook Kwon, Boli Huang, Terry G Unterman, Robert A Harris

  Source: Diabetes. 2004 Apr

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• Oxygen-dependent modulation of insulin-like growth factor binding protein biosynthesis in primary cultures of rat hepatocytes.

  Higher levels of IGF-binding protein 1 (IGFBP-1) mRNA are expressed in the less aerobic perivenous zone of the liver. Because gradients in oxygen tens…

  Authors: Jens-Gerd Scharf, Terry G Unterman, Thomas Kietzmann

  Source: Endocrinology. 2005 Dec

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• Regulation of SREBP1c gene expression in skeletal muscle: role of retinoid X receptor/liver X receptor and forkhead-O1 transcription factor.

  Sterol regulatory element binding protein 1c (SREBP1c) is a master regulator of lipogenic gene expression in liver and adipose tissue, where its expre…

  Authors: Yasutomi Kamei, Shinji Miura, Takayoshi Suganami, Fumiko Akaike, Sayaka Kanai, Satoshi Sugita, Aki Katsumata, Hiroyuki Aburatani, Terry G Unterman, Osamu Ezaki,…

  Source: Endocrinology. 2008 May

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• Advanced rat mammary cancers are growth hormone dependent.

  Epidemiological studies suggest that the GH/IGF-I axis may promote human cancers. Animal models in which the GH/IGF-I axis can be controlled may be he…

  Authors: Qi Shen, Daniel D Lantvit, Qing Lin, Yongjun Li, Konstantin Christov, Zhuohua Wang, Terry G Unterman, Rajendra G Mehta, Steven M Swanson

  Source: Endocrinology. 2007 Oct

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• FOXO1A differentially regulates genes of decidualization.

  The forkhead box O1A (FOXO1A) has been identified as one gene that is up-regulated early in the decidualization process. To further investigate the ro…

  Authors: Oscar L Buzzio, Zhenxiao Lu, Curt D Miller, Terry G Unterman, J Julie Kim

  Source: Endocrinology. 2006 Aug

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• Disruption of growth hormone signaling retards prostate carcinogenesis in the Probasin/TAg rat.

  We asked whether down-regulation of GH signaling could block carcinogenesis in the Probasin/TAg rat, a model of aggressive prostate cancer. The Sponta…

  Authors: Zhuohua Wang, Raul M Luque, Rhonda D Kineman, Vera H Ray, Konstantin T Christov, Daniel D Lantvit, Tomoyuki Shirai, Samad Hedayat, Terry G Unterman, Maarten C Bosland,…

  Source: Endocrinology. 2008 Mar

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