7 literature results

• Analysis of the role of the HIF hydroxylase family members in erythropoiesis.

  HIF (hypoxia-inducible factor) hydroxylases have been implicated in EPO (erythropoietin) production and erythropoiesis. Here we examined the role of e…

  Authors: Timothy S Fisher, Paul D Lira, Jeffrey L Stock, David G Perregaux, William H Brissette, Terence R S Ozolins, Baiyong Li

  Source: Biochemical and biophysical research communications. 2009 Oct 30

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• Defects in embryonic development of EGLN1/PHD2 knockdown transgenic mice are associated with induction of Igfbp in the placenta.

  The HIF (hypoxia inducible factor) hydroxylases EGNL1/PHD2 has been implicated in embryonic development. Here we knocked down EGNL1 in vivo by injecti…

  Authors: Terence R S Ozolins, Timothy S Fisher, Diane M Nadeau, Jeffrey L Stock, Anne S Klein, Anthony J Milici, Daniel Morton, Margaret B Wilhelms, William H Brissette, Baiyong Li

  Source: Biochemical and biophysical research communications. 2009 Dec 18

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• Cyclophosphamide and the Teratology Society: an awkward marriage.

  Cyclophosphamide (CPA) is a potent and highly effective chemotherapeutic and immunosuppressive agent that has been marketed for about 50 years. Report…

  Authors: Terence R S Ozolins

  Source: Birth defects research. Part B, Developmental and reproductive toxicology. 2010 Aug

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• Buthionine sulfoximine embryotoxicity is associated with prolonged AP-1 activation.

  Many teratogens induce oxidative stress, altering redox status and redox signaling; this has led to the suggestion that developmental toxicants act by…

  Authors: Terence R S Ozolins, Wafa Harrouk, Tonia Doerksen, Jacquetta M Trasler, Barbara F Hales

  Source: Teratology. 2002 Oct

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• Thoracic skeletal defects and cardiac malformations: a common epigenetic link?

  Congenital heart defects (CHDs) are the most common birth defects in humans. In addition, cardiac malformations represent the most frequently identifi…

  Authors: Andrea D Weston, Terence R S Ozolins, Nigel A Brown

  Source: Birth defects research. Part C, Embryo today : reviews. 2006 Dec

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• Refinement of a morphological scoring system for postimplantation rabbit conceptuses.

  The rabbit is used extensively in developmental toxicity testing, yet basic information on rabbit embryo development is lacking. The goals of this stu…

  Authors: Edward W Carney, Belen Tornesi, Charles Keller, Heather A Findlay, William S Nowland, Valerie A Marshall, Terence R S Ozolins

  Source: Birth defects research. Part B, Developmental and reproductive toxicology. 2007 Jun

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• Rat embryos express transcripts for cyclooxygenase-1 and carbonic anhydrase-4, but not for cyclooxygenase-2, during organogenesis.

  Acetylsalicylic acid (ASA) is a rat teratogen, and exposures on gestational days (GDs) 9 and 10 induce diaphragm, cardiac, and midline defects. ASA in…

  Authors: Randal D Streck, Steven W Kumpf, Terence R S Ozolins, Donald B Stedman

  Source: Birth defects research. Part B, Developmental and reproductive toxicology. 2003 Feb

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