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• Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production.

  Increased Abeta42 production has been linked to the development of Alzheimer disease. We now identify a number of compounds that raise Abeta42. Among …

  Authors: Thomas Kukar, Michael Paul Murphy, Jason L Eriksen, Sarah A Sagi, Sascha Weggen, Tawnya E Smith, Thomas Ladd, Murad A Khan, Rajashaker Kache, Jenny Beard,…

  Source: Nature medicine. 2005 May

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• NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo.

  Epidemiologic studies demonstrate that long-term use of NSAIDs is associated with a reduced risk for the development of Alzheimer disease (AD). In thi…

  Authors: Jason L Eriksen, Sarah A Sagi, Tawnya E Smith, Sascha Weggen, Pritam Das, D C McLendon, Victor V Ozols, Kevin W Jessing, Kenton H Zavitz, Edward H Koo,…

  Source: The Journal of clinical investigation. 2003 Aug

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