1 to 10 of 20 literature results

• Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis.

  Many tissues have a specific signal transduction system for endoplasmic reticulum (ER) dysfunction; however, the mechanisms underlying the ER stress r…

  Authors: Atsushi Saito, Shin-ichiro Hino, Tomohiko Murakami, Soshi Kanemoto, Shinichi Kondo, Masahiro Saitoh, Riko Nishimura, Toshiyuki Yoneda, Tatsuya Furuichi, Shiro Ikegawa,…

  Source: Nature cell biology. 2009 Oct

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• Nucleotide-sugar transporter SLC35D1 is critical to chondroitin sulfate synthesis in cartilage and skeletal development in mouse and human.

  Proteoglycans are a family of extracellular macromolecules comprised of glycosaminoglycan chains of a repeated disaccharide linked to a central core p…

  Authors: Shuichi Hiraoka, Tatsuya Furuichi, Gen Nishimura, Shunichi Shibata, Masaki Yanagishita, David L Rimoin, Andrea Superti-Furga, Peter G Nikkels, Minako Ogawa, Kayoko Katsuyama,…

  Source: Nature medicine. 2007 Nov

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• Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation.

  Eukaryotic cells have signalling pathways from the endoplasmic reticulum (ER) to cytosol and nuclei, to avoid excess accumulation of unfolded proteins…

  Authors: Tomohiko Murakami, Atsushi Saito, Shin-ichiro Hino, Shinichi Kondo, Soshi Kanemoto, Kazuyasu Chihara, Hiroshi Sekiya, Kenji Tsumagari, Kimiko Ochiai, Kazuya Yoshinaga,…

  Source: Nature cell biology. 2009 Oct

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• Core-binding factor beta interacts with Runx2 and is required for skeletal development.

  Core-binding factor beta (CBFbeta, also called polyomavirus enhancer binding protein 2beta (PEBP2B)) is associated with an inversion of chromosome 16 …

  Authors: Carolina A Yoshida, Tatsuya Furuichi, Takashi Fujita, Ryo Fukuyama, Naoko Kanatani, Shinji Kobayashi, Masanobu Satake, Kenji Takada, Toshihisa Komori

  Source: Nature genetics. 2002 Dec

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• Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog.

  The differentiation of mesenchymal cells into chondrocytes and chondrocyte proliferation and maturation are fundamental steps in skeletal development.…

  Authors: Carolina A Yoshida, Hiromitsu Yamamoto, Takashi Fujita, Tatsuya Furuichi, Kosei Ito, Ken-ichi Inoue, Kei Yamana, Akira Zanma, Kenji Takada, Yoshiaki Ito,…

  Source: Genes & development. 2004 Apr 15

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• A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation.

  Lumbar-disc herniation (LDH), one of the most common musculoskeletal diseases, has strong genetic determinants. Recently, several genes that encode ex…

  Authors: Yuichiro Hirose, Kazuhiro Chiba, Tatsuki Karasugi, Masahiro Nakajima, Yoshiharu Kawaguchi, Yasuo Mikami, Tatsuya Furuichi, Futoshi Mio, Atsushi Miyake, Takeshi Miyamoto,…

  Source: American journal of human genetics. 2008 May

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• A functional SNP in EDG2 increases susceptibility to knee osteoarthritis in Japanese.

  Osteoarthritis (OA) is the most common form of arthritis and is characterized by the gradual loss of articular cartilage. Several OA-susceptibility ge…

  Authors: Hideyuki Mototani, Aritoshi Iida, Masahiro Nakajima, Tatsuya Furuichi, Yoshinari Miyamoto, Tatsuhiko Tsunoda, Akihiro Sudo, Akihiro Kotani, Atsumasa Uchida, Kouichi Ozaki,…

  Source: Human molecular genetics. 2008 Jun 15

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• A novel dominant-negative mutation in Gdf5 generated by ENU mutagenesis impairs joint formation and causes osteoarthritis in mice.

  Growth and differentiation factor 5 (GDF5) has been implicated in chondrogenesis and joint formation, and an association of GDF5 and osteoarthritis (O…

  Authors: Hiroshi Masuya, Keiichiro Nishida, Tatsuya Furuichi, Hideaki Toki, Gen Nishimura, Hidehiko Kawabata, Haruka Yokoyama, Aki Yoshida, Sayaka Tominaga, Junko Nagano,…

  Source: Human molecular genetics. 2007 Oct 1

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• Runx2 deficiency in chondrocytes causes adipogenic changes in vitro.

  Runx2 (runt-related transcription factor 2) is an important transcription factor for chondrocyte differentiation as well as for osteoblast differentia…

  Authors: Hirayuki Enomoto, Tatsuya Furuichi, Akira Zanma, Kei Yamana, Carolina Yoshida, Satoru Sumitani, Hiroyasu Yamamoto, Motomi Enomoto-Iwamoto, Masahiro Iwamoto, Toshihisa Komori

  Source: Journal of cell science. 2004 Jan 26

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• A compound heterozygote of novel and recurrent DTDST mutations results in a novel intermediate phenotype of Desbuquois dysplasia, diastrophic dysplasia, and recessive form of multiple epiphyseal dysplasia.

  Diastrophic dysplasia sulfate transporter (DTDST) is required for synthesis of sulfated proteoglycans in cartilage, and its loss-of-function mutations…

  Authors: Atsushi Miyake, Gen Nishimura, Toru Futami, Hirofumi Ohashi, Kazuhiro Chiba, Yoshiaki Toyama, Tatsuya Furuichi, Shiro Ikegawa

  Source: Journal of human genetics. 2008

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