1 to 10 of 23 literature results

• Reprogramming of human somatic cells to pluripotency with defined factors.

  Pluripotency pertains to the cells of early embryos that can generate all of the tissues in the organism. Embryonic stem cells are embryo-derived cell…

  Authors: In-Hyun Park, Rui Zhao, Jason A West, Akiko Yabuuchi, Hongguang Huo, Tan A Ince, Paul H Lerou, M William Lensch, George Q Daley

  Source: Nature. 2008 Jan 10

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• Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression.

  The p53 tumor suppressor is a key mediator of cellular responses to various stresses. Here, we show that under conditions of basal physiologic and cel…

  Authors: Samuel Godar, Tan A Ince, George W Bell, David Feldser, Joana Liu Donaher, Jonas Bergh, Anne Liu, Kevin Miu, Randolph S Watnick, Ferenc Reinhardt,…

  Source: Cell. 2008 Jul 11

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• Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer.

  Epithelial ovarian tumors present a complex clinical, diagnostic and therapeutic challenge because of the difficulty of early detection, lack of known…

  Authors: Daniela M Dinulescu, Tan A Ince, Bradley J Quade, Sarah A Shafer, Denise Crowley, Tyler Jacks

  Source: Nature medicine. 2005 Jan

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• Systemic endocrine instigation of indolent tumor growth requires osteopontin.

  The effects of primary tumors on the host systemic environment and resulting contributions of the host to tumor growth are poorly understood. Here, we…

  Authors: Sandra S McAllister, Ann M Gifford, Ashley L Greiner, Stephen P Kelleher, Matthew P Saelzler, Tan A Ince, Ferenc Reinhardt, Lyndsay N Harris, Bonnie L Hylander, Elizabeth A Repasky,…

  Source: Cell. 2008 Jun 13

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• Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells.

  Somatic cells can be reprogrammed into induced pluripotent stem (iPS) cells by enforced expression of transcription factors. Using serial live imaging…

  Authors: Elayne M Chan, Sutheera Ratanasirintrawoot, In-Hyun Park, Philip D Manos, Yuin-Han Loh, Hongguang Huo, Justine D Miller, Odelya Hartung, Junsung Rho, Tan A Ince,…

  Source: Nature biotechnology. 2009 Nov

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• Human embryonic stem cell derivation from poor-quality embryos.

  During in vitro fertilization, embryos deemed clinically useless based on poor morphology are typically discarded. Here we demonstrate a statistical c…

  Authors: Paul H Lerou, Akiko Yabuuchi, Hongguang Huo, Ayumu Takeuchi, Jessica Shea, Tina Cimini, Tan A Ince, Elizabeth Ginsburg, Catherine Racowsky, George Q Daley

  Source: Nature biotechnology. 2008 Feb

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• Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes.

  We investigated the influence of normal cell phenotype on the neoplastic phenotype by comparing tumors derived from two different normal human mammary…

  Authors: Tan A Ince, Andrea L Richardson, George W Bell, Maki Saitoh, Samuel Godar, Antoine E Karnoub, James D Iglehart, Robert A Weinberg

  Source: Cancer cell. 2007 Aug

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• Functional genomics and the breast cancer problem.

  The clinical treatment of primary breast cancers has been greatly complicated by the inability to accurately predict which tumors will eventually beco…

  Authors: Tan A Ince, Robert A Weinberg

  Source: Cancer cell. 2002 Feb

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• Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis.

  Tumor angiogenesis is postulated to be regulated by the balance between pro- and anti-angiogenic factors. We demonstrate that the critical step in est…

  Authors: Randolph S Watnick, Yi-Ning Cheng, Annapoorni Rangarajan, Tan A Ince, Robert A Weinberg

  Source: Cancer cell. 2003 Mar

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• The terminology of teratocarcinomas and teratomas.

  Authors: M William Lensch, Tan A Ince

  Source: Nature biotechnology. 2007 Nov

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