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Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemia.
Bortezomib reversibly inhibits 26S proteasomal degradation, interferes with NF-kappaB, and exhibits antitumor activity in human malignancies. Zinc fin…
Authors: Shujun Liu, Zhongfa Liu, Zhiliang Xie, Jiuxia Pang, Jianhua Yu, Esther Lehmann, Lenguyen Huynh, Tamara Vukosavljevic, Mitsui Takeki, Rebecca B Klisovic,…
Source: Blood. 2008 Feb 15
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Long-term disease-free survivors with cytogenetically normal acute myeloid leukemia and MLL partial tandem duplication: a Cancer and Leukemia Group B study.
The clinical impact of MLL partial tandem duplication (MLL-PTD) was evaluated in 238 adults aged 18 to 59 years with cytogenetically normal (CN) de no…
Authors: Susan P Whitman, Amy S Ruppert, Guido Marcucci, Krzysztof Mrózek, Peter Paschka, Christian Langer, Claudia D Baldus, Jing Wen, Tamara Vukosavljevic, Bayard L Powell,…
Source: Blood. 2007 Jun 15
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High BAALC expression associates with other molecular prognostic markers, poor outcome, and a distinct gene-expression signature in cytogenetically normal patients younger than 60 years with acute myeloid leukemia: a Cancer and Leukemia Group B (CALGB) study.
BAALC expression is considered an independent prognostic factor in cytogenetically normal acute myeloid leukemia (CN-AML), but has yet to be investiga…
Authors: Christian Langer, Michael D Radmacher, Amy S Ruppert, Susan P Whitman, Peter Paschka, Krzysztof Mrózek, Claudia D Baldus, Tamara Vukosavljevic, Chang-Gong Liu, Mary E Ross,…
Source: Blood. 2008 Jun 1
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Independent confirmation of a prognostic gene-expression signature in adult acute myeloid leukemia with a normal karyotype: a Cancer and Leukemia Group B study.
Patients with acute myeloid leukemia (AML) and normal karyotype are classified in an intermediate-risk group, albeit this subset is heterogeneous for …
Authors: Michael D Radmacher, Guido Marcucci, Amy S Ruppert, Krzysztof Mrózek, Susan P Whitman, James W Vardiman, Peter Paschka, Tamara Vukosavljevic, Claudia D Baldus, Jonathan E Kolitz,…
Source: Blood. 2006 Sep 1
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Durable hematologic complete response and suppression of HTLV-1 viral load following alemtuzumab in zidovudine/IFN-{alpha}-refractory adult T-cell leukemia.
Adult T-cell leukemia (ATL) is a highly chemoresistant and usually fatal T-cell malignancy due to the human T-cell lymphotropic virus-1 (HTLV-1). Afte…
Authors: Andrew Mone, Shannon Puhalla, Susan Whitman, Robert A Baiocchi, Julio Cruz, Tamara Vukosavljevic, Amy Banks, Charles F Eisenbeis, John C Byrd, Michael A Caligiuri,…
Source: Blood. 2005 Nov 15
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The MLL partial tandem duplication: evidence for recessive gain-of-function in acute myeloid leukemia identifies a novel patient subgroup for molecular-targeted therapy.
MLL (ALL-1) chimeric fusions and MLL partial tandem duplications (PTD) may have mechanistically distinct contributions to leukemogenesis. Acute myeloi…
Authors: Susan P Whitman, Shujun Liu, Tamara Vukosavljevic, Laura J Rush, Li Yu, Chunhui Liu, Marko I Klisovic, Kati Maharry, Martin Guimond, Matthew P Strout,…
Source: Blood. 2005 Jul 1
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Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia.
The translocation t(8;21)(q22;q22) in acute myeloid leukemia (AML) results in the expression of the fusion protein RUNX1/MTG8, which in turn recruits …
Authors: Shujun Liu, Tiansheng Shen, Lenguyen Huynh, Marko I Klisovic, Laura J Rush, Jamie L Ford, Jianhua Yu, Brian Becknell, Yu Li, Chunhui Liu,…
Source: Cancer research. 2005 Feb 15
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Phase I study of GTI-2040, an antisense to ribonucleotide reductase, in combination with high-dose cytarabine in patients with acute myeloid leukemia.
PURPOSE: Inhibition of ribonucleotide reductase reduces the availability of the endogenous pool of deoxycytidine and may increase cytarabine (AraC) cy…
Authors: Rebecca B Klisovic, William Blum, Xiaohui Wei, Shujun Liu, Zhongfa Liu, Zhiliang Xie, Tamara Vukosavljevic, Cheryl Kefauver, Lenguyen Huynh, Jiuxia Pang,…
Source: Clinical cancer research : an official journal of the American Association for Cancer Research. 2008 Jun 15
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MicroRNA expression in cytogenetically normal acute myeloid leukemia.
BACKGROUND: A role of microRNAs in cancer has recently been recognized. However, little is known about the role of microRNAs in acute myeloid leukemia…
Authors: Guido Marcucci, Michael D Radmacher, Kati Maharry, Krzysztof Mrózek, Amy S Ruppert, Peter Paschka, Tamara Vukosavljevic, Susan P Whitman, Claudia D Baldus, Christian Langer,…
Source: The New England journal of medicine. 2008 May 1
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Targeting AML1/ETO-histone deacetylase repressor complex: a novel mechanism for valproic acid-mediated gene expression and cellular differentiation in AML1/ETO-positive acute myeloid leukemia cells.
In t(8;21) acute myeloid leukemia (AML), the AML1/ETO fusion protein promotes leukemogenesis by recruiting class I histone deacetylase (HDAC)-containi…
Authors: Shujun Liu, Rebecca B Klisovic, Tamara Vukosavljevic, Jianhua Yu, Peter Paschka, Lenguyen Huynh, Jiuxia Pang, Paolo Neviani, Zhongfa Liu, William Blum,…
Source: The Journal of pharmacology and experimental therapeutics. 2007 Jun
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