1 to 10 of 57 literature results

• The IRF family transcription factors in immunity and oncogenesis.

  The interferon regulatory factor (IRF) family, consisting of nine members in mammals, was identified in the late 1980s in the context of research into…

  Authors: Tomohiko Tamura, Hideyuki Yanai, David Savitsky, Tadatsugu Taniguchi

  Source: Annual review of immunology. 2008

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• Aimez-vous Brahms? A story capriccioso from the discovery of a cytokine family and its regulators.

  Authors: Tadatsugu Taniguchi

  Source: Nature immunology. 2009 May

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• The contribution of transcription factor IRF1 to the interferon-gamma-interleukin 12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cells.

  Interleukin-12 (IL-12) and interferon-gamma (IFN-gamma) drive T helper type 1 (T(H)1) differentiation, but the mechanisms underlying the regulation of…

  Authors: Shin-ichi Kano, Kojiro Sato, Yasuyuki Morishita, Sabine Vollstedt, Sunhwa Kim, Keith Bishop, Kenya Honda, Masato Kubo, Tadatsugu Taniguchi

  Source: Nature immunology. 2008 Jan

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• HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses.

  The activation of innate immune responses by nucleic acids is crucial to protective and pathological immunities and is mediated by the transmembrane T…

  Authors: Hideyuki Yanai, Tatsuma Ban, ZhiChao Wang, Myoung Kwon Choi, Takeshi Kawamura, Hideo Negishi, Makoto Nakasato, Yan Lu, Sho Hangai, Ryuji Koshiba,…

  Source: Nature. 2009 Nov 5

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• DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response.

  Central to innate immunity is the sensing of pathogen-associated molecular patterns by cytosolic and membrane-associated receptors. In particular, DNA…

  Authors: Akinori Takaoka, Zhichao Wang, Myoung Kwon Choi, Hideyuki Yanai, Hideo Negishi, Tatsuma Ban, Yan Lu, Makoto Miyagishi, Tatsuhiko Kodama, Kenya Honda,…

  Source: Nature. 2007 Jul 26

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• Regulation of the cytosolic DNA-sensing system in innate immunity: a current view.

  The sensing of nucleic acids by pattern recognition receptors is a central feature of innate immunity and is mediated by two types of receptors, Toll-…

  Authors: Hideyuki Yanai, David Savitsky, Tomohiko Tamura, Tadatsugu Taniguchi

  Source: Current opinion in immunology. 2009 Feb

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• Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors.

  Induction of type I interferons (IFNs) by viruses and other pathogens is crucial for innate immunity, and it is mediated by the activation of pattern-…

  Authors: Kenya Honda, Akinori Takaoka, Tadatsugu Taniguchi

  Source: Immunity. 2006 Sep

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• Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction.

  Robust type-I interferon (IFN-alpha/beta) induction in plasmacytoid dendritic cells, through the activation of Toll-like receptor 9 (TLR9), constitute…

  Authors: Kenya Honda, Yusuke Ohba, Hideyuki Yanai, Hideo Negishi, Tatsuaki Mizutani, Akinori Takaoka, Choji Taya, Tadatsugu Taniguchi

  Source: Nature. 2005 Apr 21

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• IRF-7 is the master regulator of type-I interferon-dependent immune responses.

  The type-I interferon (IFN-alpha/beta) response is critical to immunity against viruses and can be triggered in many cell types by cytosolic detection…

  Authors: Kenya Honda, Hideyuki Yanai, Hideo Negishi, Masataka Asagiri, Mitsuharu Sato, Tatsuaki Mizutani, Naoya Shimada, Yusuke Ohba, Akinori Takaoka, Nobuaki Yoshida,…

  Source: Nature. 2005 Apr 7

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• Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors.

  The activation of Toll-like receptors (TLRs) is central to innate and adaptive immunity. All TLRs use the adaptor MyD88 for signalling, but the mechan…

  Authors: Akinori Takaoka, Hideyuki Yanai, Seiji Kondo, Gordon Duncan, Hideo Negishi, Tatsuaki Mizutani, Shin-Ichi Kano, Kenya Honda, Yusuke Ohba, Tak W Mak,…

  Source: Nature. 2005 Mar 10

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