1 to 10 of 2,169 literature results

• SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta.

  Obesity and metabolic syndrome are increasingly recognized as major risk factors for cardiovascular disease. Herein we show that Krüppel-like transcri…

  Authors: Yumiko Oishi, Ichiro Manabe, Kazuyuki Tobe, Mitsuru Ohsugi, Tetsuya Kubota, Katsuhito Fujiu, Koji Maemura, Naoto Kubota, Takashi Kadowaki, Ryozo Nagai

  Source: Nature medicine. 2008 Jun

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• The Daphniphyllum alkaloids.

  About two hundred Daphniphyllum alkaloids have so far been isolated from thirteen species of the genus Daphniphyllum. This comprehensive review summar…

  Authors: Jun'ichi Kobayashi, Takaaki Kubota

  Source: Natural product reports. 2009 Jul

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• Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions.

  Adiponectin plays a central role as an antidiabetic and antiatherogenic adipokine. AdipoR1 and AdipoR2 serve as receptors for adiponectin in vitro, an…

  Authors: Toshimasa Yamauchi, Yasunori Nio, Toshiyuki Maki, Masaki Kobayashi, Takeshi Takazawa, Masato Iwabu, Miki Okada-Iwabu, Sachiko Kawamoto, Naoto Kubota, Tetsuya Kubota,…

  Source: Nature medicine. 2007 Mar

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• The feedback phase of type I interferon induction in dendritic cells requires interferon regulatory factor 8.

  Dendritic cells (DCs) produce type I interferons (IFNs) in greater amounts than other cells, but the mechanisms remain elusive. Here we studied the ro…

  Authors: Prafullakumar Tailor, Tomohiko Tamura, Hee Jeong Kong, Toru Kubota, Mayumi Kubota, Paola Borghi, Lucia Gabriele, Keiko Ozato

  Source: Immunity. 2007 Aug

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• Stereoselective aldol reaction of glutarimides using pseudo C(2) symmetry.

  The boron aldol reaction of beta-substituted glutaric imides bearing an oxazolidinone-based auxiliary proceeds with excellent diastereoselectivity; sw…

  Authors: Yohsuke Watanabe, Takashi Yamazaki, Toshio Kubota

  Source: Organic letters. 2010 Jan 15

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• The role of S-1 in the treatment of gastric cancer.

  S-1 is a potent antitumour drug in gastric cancer. After years of disagreement about the utility of chemotherapy for advanced gastric cancer, several …

  Authors: T Kubota

  Source: British journal of cancer. 2008 Apr 22

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• Retinoid ameliorates experimental autoimmune myositis, with modulation of Th cell differentiation and antibody production in vivo.

  OBJECTIVE: Polymyositis and dermatomyositis are chronic inflammatory muscle diseases. Retinoids are compounds that bind to the retinoic acid binding s…

  Authors: Naho Ohyanagi, Miwako Ishido, Fumihito Suzuki, Kayoko Kaneko, Tetsuo Kubota, Nobuyuki Miyasaka, Toshihiro Nanki

  Source: Arthritis and rheumatism. 2009 Oct

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• Down-regulation of RhoA is involved in the cytotoxic action of lipophilic statins in HepG2 cells.

  OBJECTIVE: Hepatotoxicity is one of the major complaints that occur during lipid-lowering therapy with 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reduct…

  Authors: Asuka Maeda, Takahisa Yano, Yoshinori Itoh, Midori Kakumori, Toshio Kubota, Nobuaki Egashira, Ryozo Oishi

  Source: Atherosclerosis. 2010 Jan

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• Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells.

  The recruitment of basophils into the sites of allergic inflammation is often observed. However, no definitive evidence has been provided that basophi…

  Authors: Kaori Mukai, Kunie Matsuoka, Choji Taya, Hidenori Suzuki, Hiroo Yokozeki, Kiyoshi Nishioka, Katsuiku Hirokawa, Maki Etori, Makoto Yamashita, Toshiyuki Kubota,…

  Source: Immunity. 2005 Aug

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• Zamamidines A and B, new manzamine alkaloids from the sponge Amphimedon species.

  New manzamine alkaloids, zamamidines A (1) and B (2), have been isolated from an Okinawan marine sponge Amphimedon species. The structures and stereoc…

  Authors: Yohei Takahashi, Takaaki Kubota, Jane Fromont, Jun'ichi Kobayashi

  Source: Organic letters. 2009 Jan 1

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