1 to 9 of 9 literature results

• Pharmaco-metabonomic phenotyping and personalized drug treatment.

  There is a clear case for drug treatments to be selected according to the characteristics of an individual patient, in order to improve efficacy and r…

  Authors: T Andrew Clayton, John C Lindon, Olivier Cloarec, Henrik Antti, Claude Charuel, Gilles Hanton, Jean-Pierre Provost, Jean-Loïc Le Net, David Baker, Rosalind J Walley,…

  Source: Nature. 2006 Apr 20

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• Mechanistic aspects and novel biomarkers of responder and non-responder phenotypes in galactosamine-induced hepatitis.

  The amino sugar galactosamine (galN) induces alterations in the hepatic uridine nucleotide pool and has been widely used as a model of human viral hep…

  Authors: Muireann Coen, Elizabeth J Want, T Andrew Clayton, Cynthia M Rhode, Young Shick Hong, Hector C Keun, Glenn H Cantor, Alan L Metz, Donald G Robertson, Michael D Reily,…

  Source: Journal of proteome research. 2009 Nov

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• An integrated metabonomic approach to describe temporal metabolic disregulation induced in the rat by the model hepatotoxin allyl formate.

  The time-related metabolic events in rat liver, plasma, and urine following hepatotoxic insult with allyl formate (75 mg/kg) were studied using a comb…

  Authors: Ivan K S Yap, T Andrew Clayton, Huiru Tang, Jeremy R Everett, Gilles Hanton, Jean-Pierre Provost, Jean-Loic Le Net, Claude Charuel, John C Lindon, Jeremy K Nicholson

  Source: Journal of proteome research. 2006 Oct

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• Hepatotoxin-induced hypertyrosinemia and its toxicological significance.

  A (1)H Nuclear Magnetic Resonance (NMR) spectroscopic investigation of the effects of single doses of four model hepatotoxins on male Sprague-Dawley r…

  Authors: T Andrew Clayton, John C Lindon, Jeremy R Everett, Claude Charuel, Gilles Hanton, Jean-Loic Le Net, Jean-Pierre Provost, Jeremy K Nicholson

  Source: Archives of toxicology. 2007 Mar

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• A high-performance liquid chromatography and nuclear magnetic resonance spectroscopy-based analysis of commercially available praziquantel tablets.

  The amount of active ingredient in 20 commercially sourced batches of praziquantel (PZQ) tablets was determined using a high-performance liquid chroma…

  Authors: Jia Li, Yulan Wang, Alan Fenwick, T Andrew Clayton, Yu Y K Lau, Cristina Legido-Quigley, John C Lindon, Jürg Utzinger, Elaine Holmes

  Source: Journal of pharmaceutical and biomedical analysis. 2007 Oct 18

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• Diastereoisomeric singly bridged cyclophosphazene-macrocyclic compounds.

  31P NMR spectroscopy and added chiral shift reagent (CSR) or chiral solvating agent (CSA) have been used to show that unsymmetrically substituted sing…

  Authors: Iwona Porwolik-Czomperlik, Krystyna Brandt, T Andrew Clayton, David B Davies, Robert J Eaton, Robert A Shaw

  Source: Inorganic chemistry. 2002 Sep 23

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• Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism.

  We provide a demonstration in humans of the principle of pharmacometabonomics by showing a clear connection between an individual's metabolic phenotyp…

  Authors: T Andrew Clayton, David Baker, John C Lindon, Jeremy R Everett, Jeremy K Nicholson

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2009 Aug 25

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• Hepatotoxin-induced hypercreatinaemia and hypercreatinuria: their relationship to one another, to liver damage and to weakened nutritional status.

  Hypercreatinuria is a well-known feature of liver and testicular toxicity and we have recently proposed that hepatotoxin-induced hypercreatinuria woul…

  Authors: T Andrew Clayton, John C Lindon, Jeremy R Everett, Claude Charuel, Gilles Hanton, Jean-Loic Le Net, Jean-Pierre Provost, Jeremy K Nicholson

  Source: Archives of toxicology. 2004 Feb

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• An hypothesis for a mechanism underlying hepatotoxin-induced hypercreatinuria.

  As part of a wider metabonomic investigation into the early detection and discrimination of site-specific hepatotoxicity, male Sprague-Dawley rats wer…

  Authors: T Andrew Clayton, John C Lindon, Jeremy R Everett, Claude Charuel, Gilles Hanton, Jean-Loic Le Net, Jean-Pierre Provost, Jeremy K Nicholson

  Source: Archives of toxicology. 2003 Apr

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