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1 to 9 of 9 literature results
There is a clear case for drug treatments to be selected according to the characteristics of an individual patient, in order to improve efficacy and r…
Authors: T Andrew Clayton, John C Lindon, Olivier Cloarec, Henrik Antti, Claude Charuel, Gilles Hanton, Jean-Pierre Provost, Jean-Loïc Le Net, David Baker, Rosalind J Walley,…
Source: Nature. 2006 Apr 20
View Full TextThe amino sugar galactosamine (galN) induces alterations in the hepatic uridine nucleotide pool and has been widely used as a model of human viral hep…
Authors: Muireann Coen, Elizabeth J Want, T Andrew Clayton, Cynthia M Rhode, Young Shick Hong, Hector C Keun, Glenn H Cantor, Alan L Metz, Donald G Robertson, Michael D Reily,…
Source: Journal of proteome research. 2009 Nov
View Full TextThe time-related metabolic events in rat liver, plasma, and urine following hepatotoxic insult with allyl formate (75 mg/kg) were studied using a comb…
Authors: Ivan K S Yap, T Andrew Clayton, Huiru Tang, Jeremy R Everett, Gilles Hanton, Jean-Pierre Provost, Jean-Loic Le Net, Claude Charuel, John C Lindon, Jeremy K Nicholson
Source: Journal of proteome research. 2006 Oct
View Full TextA (1)H Nuclear Magnetic Resonance (NMR) spectroscopic investigation of the effects of single doses of four model hepatotoxins on male Sprague-Dawley r…
Authors: T Andrew Clayton, John C Lindon, Jeremy R Everett, Claude Charuel, Gilles Hanton, Jean-Loic Le Net, Jean-Pierre Provost, Jeremy K Nicholson
Source: Archives of toxicology. 2007 Mar
View Full TextThe amount of active ingredient in 20 commercially sourced batches of praziquantel (PZQ) tablets was determined using a high-performance liquid chroma…
Authors: Jia Li, Yulan Wang, Alan Fenwick, T Andrew Clayton, Yu Y K Lau, Cristina Legido-Quigley, John C Lindon, Jürg Utzinger, Elaine Holmes
Source: Journal of pharmaceutical and biomedical analysis. 2007 Oct 18
View Full Text31P NMR spectroscopy and added chiral shift reagent (CSR) or chiral solvating agent (CSA) have been used to show that unsymmetrically substituted sing…
Authors: Iwona Porwolik-Czomperlik, Krystyna Brandt, T Andrew Clayton, David B Davies, Robert J Eaton, Robert A Shaw
Source: Inorganic chemistry. 2002 Sep 23
View Full TextWe provide a demonstration in humans of the principle of pharmacometabonomics by showing a clear connection between an individual's metabolic phenotyp…
Authors: T Andrew Clayton, David Baker, John C Lindon, Jeremy R Everett, Jeremy K Nicholson
Source: Proceedings of the National Academy of Sciences of the United States of America. 2009 Aug 25
View Free Full TextHypercreatinuria is a well-known feature of liver and testicular toxicity and we have recently proposed that hepatotoxin-induced hypercreatinuria woul…
Authors: T Andrew Clayton, John C Lindon, Jeremy R Everett, Claude Charuel, Gilles Hanton, Jean-Loic Le Net, Jean-Pierre Provost, Jeremy K Nicholson
Source: Archives of toxicology. 2004 Feb
View Full TextAs part of a wider metabonomic investigation into the early detection and discrimination of site-specific hepatotoxicity, male Sprague-Dawley rats wer…
Authors: T Andrew Clayton, John C Lindon, Jeremy R Everett, Claude Charuel, Gilles Hanton, Jean-Loic Le Net, Jean-Pierre Provost, Jeremy K Nicholson
Source: Archives of toxicology. 2003 Apr
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