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1 to 10 of 86 literature results
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Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1.
The major mood disorders, which include bipolar disorder and major depressive disorder (MDD), are considered heritable traits, although previous genet…
Authors: Francis J McMahon, Nirmala Akula, Thomas G Schulze, Pierandrea Muglia, Federica Tozzi, Sevilla D Detera-Wadleigh, C J M Steele, René Breuer, Jana Strohmaier, Jens R Wendland,…
Source: Nature genetics. 2010 Feb
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Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate.
We conducted a genome-wide association study for nonsyndromic cleft lip with or without cleft palate (NSCL/P) in 401 affected individuals and 1,323 co…
Authors: Elisabeth Mangold, Kerstin U Ludwig, Stefanie Birnbaum, Carlotta Baluardo, Melissa Ferrian, Stefan Herms, Heiko Reutter, Nilma Almeida de Assis, Taofik Al Chawa, Manuel Mattheisen,…
Source: Nature genetics. 2010 Jan
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Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24.
We conducted a genome-wide association study involving 224 cases and 383 controls of Central European origin to identify susceptibility loci for nonsy…
Authors: Stefanie Birnbaum, Kerstin U Ludwig, Heiko Reutter, Stefan Herms, Michael Steffens, Michele Rubini, Carlotta Baluardo, Melissa Ferrian, Nilma Almeida de Assis, Margrieta A Alblas,…
Source: Nature genetics. 2009 Apr
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Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis.
Marie Unna hereditary hypotrichosis (MUHH) is an autosomal dominant form of genetic hair loss. In a large Chinese family carrying MUHH, we identified …
Authors: Yaran Wen, Yang Liu, Yiming Xu, Yiwei Zhao, Rui Hua, Kaibo Wang, Miao Sun, Yuanhong Li, Sen Yang, Xue-Jun Zhang,…
Source: Nature genetics. 2009 Feb
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Susceptibility variants for male-pattern baldness on chromosome 20p11.
We carried out a genome-wide association study in 296 individuals with male-pattern baldness (androgenetic alopecia) and 347 controls. We then investi…
Authors: Axel M Hillmer, Felix F Brockschmidt, Sandra Hanneken, Sibylle Eigelshoven, Michael Steffens, Antonia Flaquer, Stefan Herms, Tim Becker, Anne-Katrin Kortüm, Dale R Nyholt,…
Source: Nature genetics. 2008 Nov
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Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis.
We conducted a genome-wide association study among 2,323 individuals with sporadic amyotrophic lateral sclerosis (ALS) and 9,013 control subjects and …
Authors: Michael A van Es, Jan H Veldink, Christiaan G J Saris, Hylke M Blauw, Paul W J van Vught, Anna Birve, Robin Lemmens, Helenius J Schelhaas, Ewout J N Groen, Mark H B Huisman,…
Source: Nature genetics. 2009 Oct
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Microduplications of 16p11.2 are associated with schizophrenia.
Recurrent microdeletions and microduplications of a 600-kb genomic region of chromosome 16p11.2 have been implicated in childhood-onset developmental …
Authors: Shane E McCarthy, Vladimir Makarov, George Kirov, Anjene M Addington, Jon McClellan, Seungtai Yoon, Diana O Perkins, Diane E Dickel, Mary Kusenda, Olga Krastoshevsky,…
Source: Nature genetics. 2009 Nov
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Large recurrent microdeletions associated with schizophrenia.
Reduced fecundity, associated with severe mental disorders, places negative selection pressure on risk alleles and may explain, in part, why common va…
Authors: Hreinn Stefansson, Dan Rujescu, Sven Cichon, Olli P H Pietiläinen, Andres Ingason, Stacy Steinberg, Ragnheidur Fossdal, Engilbert Sigurdsson, Thordur Sigmundsson, Jacobine E Buizer-Voskamp,…
Source: Nature. 2008 Sep 11
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Identification of loci associated with schizophrenia by genome-wide association and follow-up.
We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10(-5) in up to 16,726 additional…
Authors: Michael C O'Donovan, Nicholas Craddock, Nadine Norton, Hywel Williams, Timothy Peirce, Valentina Moskvina, Ivan Nikolov, Marian Hamshere, Liam Carroll, Lyudmila Georgieva,…
Source: Nature genetics. 2008 Sep
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Common variants conferring risk of schizophrenia.
Schizophrenia is a complex disorder, caused by both genetic and environmental factors and their interactions. Research on pathogenesis has traditional…
Authors: Hreinn Stefansson, Roel A Ophoff, Stacy Steinberg, Ole A Andreassen, Sven Cichon, Dan Rujescu, Thomas Werge, Olli P H Pietiläinen, Ole Mors, Preben B Mortensen,…
Source: Nature. 2009 Aug 6
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