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The major mood disorders, which include bipolar disorder and major depressive disorder (MDD), are considered heritable traits, although previous genet…
Authors: Francis J McMahon, Nirmala Akula, Thomas G Schulze, Pierandrea Muglia, Federica Tozzi, Sevilla D Detera-Wadleigh, C J M Steele, René Breuer, Jana Strohmaier, Jens R Wendland,…
Source: Nature genetics. 2010 Feb
View Full TextWe conducted a genome-wide association study for nonsyndromic cleft lip with or without cleft palate (NSCL/P) in 401 affected individuals and 1,323 co…
Authors: Elisabeth Mangold, Kerstin U Ludwig, Stefanie Birnbaum, Carlotta Baluardo, Melissa Ferrian, Stefan Herms, Heiko Reutter, Nilma Almeida de Assis, Taofik Al Chawa, Manuel Mattheisen,…
Source: Nature genetics. 2010 Jan
View Full TextWe conducted a genome-wide association study involving 224 cases and 383 controls of Central European origin to identify susceptibility loci for nonsy…
Authors: Stefanie Birnbaum, Kerstin U Ludwig, Heiko Reutter, Stefan Herms, Michael Steffens, Michele Rubini, Carlotta Baluardo, Melissa Ferrian, Nilma Almeida de Assis, Margrieta A Alblas,…
Source: Nature genetics. 2009 Apr
View Full TextMarie Unna hereditary hypotrichosis (MUHH) is an autosomal dominant form of genetic hair loss. In a large Chinese family carrying MUHH, we identified …
Authors: Yaran Wen, Yang Liu, Yiming Xu, Yiwei Zhao, Rui Hua, Kaibo Wang, Miao Sun, Yuanhong Li, Sen Yang, Xue-Jun Zhang,…
Source: Nature genetics. 2009 Feb
View Full TextWe carried out a genome-wide association study in 296 individuals with male-pattern baldness (androgenetic alopecia) and 347 controls. We then investi…
Authors: Axel M Hillmer, Felix F Brockschmidt, Sandra Hanneken, Sibylle Eigelshoven, Michael Steffens, Antonia Flaquer, Stefan Herms, Tim Becker, Anne-Katrin Kortüm, Dale R Nyholt,…
Source: Nature genetics. 2008 Nov
View Full TextWe conducted a genome-wide association study among 2,323 individuals with sporadic amyotrophic lateral sclerosis (ALS) and 9,013 control subjects and …
Authors: Michael A van Es, Jan H Veldink, Christiaan G J Saris, Hylke M Blauw, Paul W J van Vught, Anna Birve, Robin Lemmens, Helenius J Schelhaas, Ewout J N Groen, Mark H B Huisman,…
Source: Nature genetics. 2009 Oct
View Full TextRecurrent microdeletions and microduplications of a 600-kb genomic region of chromosome 16p11.2 have been implicated in childhood-onset developmental …
Authors: Shane E McCarthy, Vladimir Makarov, George Kirov, Anjene M Addington, Jon McClellan, Seungtai Yoon, Diana O Perkins, Diane E Dickel, Mary Kusenda, Olga Krastoshevsky,…
Source: Nature genetics. 2009 Nov
View Full TextReduced fecundity, associated with severe mental disorders, places negative selection pressure on risk alleles and may explain, in part, why common va…
Authors: Hreinn Stefansson, Dan Rujescu, Sven Cichon, Olli P H Pietiläinen, Andres Ingason, Stacy Steinberg, Ragnheidur Fossdal, Engilbert Sigurdsson, Thordur Sigmundsson, Jacobine E Buizer-Voskamp,…
Source: Nature. 2008 Sep 11
View Free Full TextWe carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10(-5) in up to 16,726 additional…
Authors: Michael C O'Donovan, Nicholas Craddock, Nadine Norton, Hywel Williams, Timothy Peirce, Valentina Moskvina, Ivan Nikolov, Marian Hamshere, Liam Carroll, Lyudmila Georgieva,…
Source: Nature genetics. 2008 Sep
View Full TextSchizophrenia is a complex disorder, caused by both genetic and environmental factors and their interactions. Research on pathogenesis has traditional…
Authors: Hreinn Stefansson, Roel A Ophoff, Stacy Steinberg, Ole A Andreassen, Sven Cichon, Dan Rujescu, Thomas Werge, Olli P H Pietiläinen, Ole Mors, Preben B Mortensen,…
Source: Nature. 2009 Aug 6
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