1 to 8 of 8 literature results

• Identification of ten loci associated with height highlights new biological pathways in human growth.

  Height is a classic polygenic trait, reflecting the combined influence of multiple as-yet-undiscovered genetic factors. We carried out a meta-analysis…

  Authors: Guillaume Lettre, Anne U Jackson, Christian Gieger, Fredrick R Schumacher, Sonja I Berndt, Serena Sanna, Susana Eyheramendy, Benjamin F Voight, Johannah L Butler, Candace Guiducci,…

  Source: Nature genetics. 2008 May

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• A model-based approach to capture genetic variation for future association studies.

  Genome-wide association studies are still constrained by the cost of genotyping. For this reason, the selection of a reduced set of markers or tags ab…

  Authors: Susana Eyheramendy, Jonathan Marchini, Gilean McVean, Simon Myers, Peter Donnelly

  Source: Genome research. 2007 Jan

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• Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations.

  Hypertension is a complex disease that affects a large proportion of adult population. Although approximately half of the inter-individual variance in…

  Authors: Elin Org, Susana Eyheramendy, Peeter Juhanson, Christian Gieger, Peter Lichtner, Norman Klopp, Gudrun Veldre, Angela Döring, Margus Viigimaa, Siim Sõber,…

  Source: Human molecular genetics. 2009 Jun 15

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• A second generation human haplotype map of over 3.1 million SNPs.

  We describe the Phase II HapMap, which characterizes over 3.1 million human single nucleotide polymorphisms (SNPs) genotyped in 270 individuals from f…

  Authors: International HapMap Consortium, Kelly A Frazer, Dennis G Ballinger, David R Cox, David A Hinds, Laura L Stuve, Richard A Gibbs, John W Belmont, Andrew Boudreau, Paul Hardenbol,…

  Source: Nature. 2007 Oct 18

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• Genome-wide detection and characterization of positive selection in human populations.

  With the advent of dense maps of human genetic variation, it is now possible to detect positive natural selection across the human genome. Here we rep…

  Authors: Pardis C Sabeti, Patrick Varilly, Ben Fry, Jason Lohmueller, Elizabeth Hostetter, Chris Cotsapas, Xiaohui Xie, Elizabeth H Byrne, Steven A McCarroll, Rachelle Gaudet,…

  Source: Nature. 2007 Oct 18

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• Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array.

  The outcome of Genome-Wide Association Studies (GWAS) has challenged the field of blood pressure (BP) genetics as previous candidate genes have not be…

  Authors: Siim Sõber, Elin Org, Katrin Kepp, Peeter Juhanson, Susana Eyheramendy, Christian Gieger, Peter Lichtner, Norman Klopp, Gudrun Veldre, Margus Viigimaa,…

  Source: PloS one. 2009

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• Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion.

  WNK1--a serine/threonine kinase involved in electrolyte homeostasis and blood pressure (BP) control--is an excellent candidate gene for essential hype…

  Authors: Stephen Newhouse, Martin Farrall, Chris Wallace, Mimoza Hoti, Beverley Burke, Philip Howard, Abiodun Onipinla, Kate Lee, Sue Shaw-Hawkins, Richard Dobson,…

  Source: PloS one. 2009

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• SLC2A9 is a high-capacity urate transporter in humans.

  BACKGROUND: Serum uric acid levels in humans are influenced by diet, cellular breakdown, and renal elimination, and correlate with blood pressure, met…

  Authors: Mark J Caulfield, Patricia B Munroe, Deb O'Neill, Kate Witkowska, Fadi J Charchar, Manuel Doblado, Sarah Evans, Susana Eyheramendy, Abiodun Onipinla, Philip Howard,…

  Source: PLoS medicine. 2008 Oct 7

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