1 to 10 of 48 literature results

• Why aging T cells fail: implications for vaccination.

  The decline in CD4+ T cell function with aging contributes to reduced vaccine efficacy. In this commentary, we discuss the factors leading to age-rela…

  Authors: Laura Haynes, Susan L Swain

  Source: Immunity. 2006 Jun

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• T-cell immunosenescence: lessons learned from mouse models of aging.

  It is well established that increasing age is associated with a decreased capacity of the immune system to mediate effective immune responses to vacci…

  Authors: Alexander C Maue, Eric J Yager, Susan L Swain, David L Woodland, Marcia A Blackman, Laura Haynes

  Source: Trends in immunology. 2009 Jul

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• IL-7: maintaining T-cell memory and achieving homeostasis.

  During an immune response, peripheral T-cell populations expand and then contract as the response subsides, thus maintaining a fairly constant number …

  Authors: Linda M Bradley, Laura Haynes, Susan L Swain

  Source: Trends in immunology. 2005 Mar

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• IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge.

  Interferon-gamma is key in limiting Mycobacterium tuberculosis infection. Here we show that vaccination triggered an accelerated interferon-gamma resp…

  Authors: Shabaana A Khader, Guy K Bell, John E Pearl, Jeffrey J Fountain, Javier Rangel-Moreno, Garth E Cilley, Fang Shen, Sheri M Eaton, Sarah L Gaffen, Susan L Swain,…

  Source: Nature immunology. 2007 Apr

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• SAP deficiency results in a striking alteration of the protein profile in activated CD4 T cells.

  Deficiency in a protein called signaling lymphocytic activation molecule-associated protein (SAP) causes X-linked lymphoproliferative disease (XLP) an…

  Authors: Cris Kamperschroer, Susan L Swain, Thomas Grussenmeyer, Ivan Lefkovits

  Source: Journal of proteome research. 2006 Jul

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• Functionally diverse subsets in CD4 T cell responses against influenza.

  BACKGROUND: Antibody alone cannot provide optimal protection against many infectious diseases impacting global heath. In these cases, our challenge is…

  Authors: Tara M Strutt, K Kai McKinstry, Susan L Swain

  Source: Journal of clinical immunology. 2009 Mar

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• The effector to memory transition of CD4 T cells.

  The small number of antigen-specific memory CD4 T cells surviving long-term after antigen or pathogen challenge are often characterized by a surprisin…

  Authors: K Kai McKinstry, Tara M Strutt, Susan L Swain

  Source: Immunologic research. 2008

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• CD4 T cell responses to influenza infection.

  Immune responses to viral infections involve a complex orchestration between innate signals and adaptive responses of specific T and B cells. Anti-vir…

  Authors: Deborah M Brown, Eulogia Román, Susan L Swain

  Source: Seminars in immunology. 2004 Jun

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• IL-2 and antigen dose differentially regulate perforin- and FasL-mediated cytolytic activity in antigen specific CD4+ T cells.

  CD4 T cell effectors can promote survival against lethal influenza virus via perforin mediated cytolytic mechanisms; however, our understanding of how…

  Authors: Deborah M Brown, Cris Kamperschroer, Allison M Dilzer, Deborah M Roberts, Susan L Swain

  Source: Cellular immunology. 2009

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• CD4+ T-cell memory: generation and multi-faceted roles for CD4+ T cells in protective immunity to influenza.

  We have outlined the carefully orchestrated process of CD4+ T-cell differentiation from naïve to effector and from effector to memory cells with a foc…

  Authors: Susan L Swain, Javed N Agrewala, Deborah M Brown, Dawn M Jelley-Gibbs, Susanne Golech, Gail Huston, Stephen C Jones, Cris Kamperschroer, Won-Ha Lee, K Kai McKinstry,…

  Source: Immunological reviews. 2006 Jun

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