1 to 8 of 8 literature results

• Hepatic insulin resistance directly promotes formation of cholesterol gallstones.

  Despite the well-documented association between gallstones and the metabolic syndrome, the mechanistic links between these two disorders remain unknow…

  Authors: Sudha B Biddinger, Joel T Haas, Bian B Yu, Olivier Bezy, Enxuan Jing, Wenwei Zhang, Terry G Unterman, Martin C Carey, C Ronald Kahn

  Source: Nature medicine. 2008 Jul

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• From mice to men: insights into the insulin resistance syndromes.

  The insulin resistance syndrome refers to a constellation of findings, including glucose intolerance, obesity, dyslipidemia, and hypertension, that pr…

  Authors: Sudha B Biddinger, C Ronald Kahn

  Source: Annual review of physiology. 2006

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• Dissecting the role of insulin resistance in the metabolic syndrome.

  PURPOSE OF REVIEW: Over 20 years ago, insulin resistance was postulated to play a central role in the pathogenesis of the metabolic syndrome. However,…

  Authors: Joel T Haas, Sudha B Biddinger

  Source: Current opinion in lipidology. 2009 Jun

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• Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c.

  Stearoyl-CoA desaturase (SCD)1 catalyzes the rate-limiting reaction of monounsaturated fatty acid (MUFA) synthesis and plays an important role in the …

  Authors: Sudha B Biddinger, Makoto Miyazaki, Jeremie Boucher, James M Ntambi, C Ronald Kahn

  Source: Diabetes. 2006 Jul

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• Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome.

  Both environmental and genetic factors play important roles in the development of the metabolic syndrome. To elucidate how these factors interact unde…

  Authors: Sudha B Biddinger, Katrine Almind, Makoto Miyazaki, Efi Kokkotou, James M Ntambi, C Ronald Kahn

  Source: Diabetes. 2005 May

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• High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice.

  Liver-specific insulin receptor knock-out (LIRKO) mice display hyperinsulinemia, abnormal glucose metabolism, and progressive liver dysfunction. In ad…

  Authors: Shmuel E Cohen, Efi Kokkotou, Sudha B Biddinger, Tatsuya Kondo, Rolf Gebhardt, Juergen Kratzsch, Christos S Mantzoros, C Ronald Kahn

  Source: The Journal of biological chemistry. 2007 Aug 10

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• Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis.

  Insulin resistance plays a central role in the development of the metabolic syndrome, but how it relates to cardiovascular disease remains controversi…

  Authors: Sudha B Biddinger, Antonio Hernandez-Ono, Christian Rask-Madsen, Joel T Haas, José O Alemán, Ryo Suzuki, Erez F Scapa, Chhavi Agarwal, Martin C Carey, Gregory Stephanopoulos,…

  Source: Cell metabolism. 2008 Feb

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• The insulin-like growth factor axis: a potential link between glycemic index and cancer.

  Authors: Sudha B Biddinger, David S Ludwig

  Source: The American journal of clinical nutrition. 2005 Aug

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