1 to 10 of 13 literature results

• Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase.

  Protein kinases have central functions in various cellular signal transduction pathways through their substrate phosphorylation. Here we show that a p…

  Authors: Subbareddy Maddika, Junjie Chen

  Source: Nature cell biology. 2009 Apr

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• Unscheduled Akt-triggered activation of cyclin-dependent kinase 2 as a key effector mechanism of apoptin's anticancer toxicity.

  Apoptin, a protein from the chicken anemia virus, has attracted attention because it specifically kills tumor cells while leaving normal cells unharme…

  Authors: Subbareddy Maddika, Soumya Panigrahi, Emilia Wiechec, Sebastian Wesselborg, Ute Fischer, Klaus Schulze-Osthoff, Marek Los

  Source: Molecular and cellular biology. 2009 Mar

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• Akt-mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis.

  Here, we show that CDK2, an S-phase cyclin-dependent kinase, is a novel target for Akt during cell cycle progression and apoptosis. Akt phosphorylates…

  Authors: Subbareddy Maddika, Sudharsana Rao Ande, Emilia Wiechec, Lise Lotte Hansen, Sebastian Wesselborg, Marek Los

  Source: Journal of cell science. 2008 Apr 1

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• The ubiquitin pathway: an emerging drug target in cancer therapy.

  Ubiquitination is a highly ordered multistep enzymatic process, carried out by a well-defined systematic ubiquitin pathway, which is required for main…

  Authors: Sudharsana Rao Ande, Junjie Chen, Subbareddy Maddika

  Source: European journal of pharmacology. 2009 Dec 25

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• Cancer-specific toxicity of apoptin is independent of death receptors but involves the loss of mitochondrial membrane potential and the release of mitochondrial cell-death mediators by a Nur77-dependent pathway.

  Apoptin, a small proline-rich protein derived from the chicken anaemia virus, induces cell death selectively in cancer cells. The signalling pathways …

  Authors: Subbareddy Maddika, Evan P Booy, Dina Johar, Spencer B Gibson, Saeid Ghavami, Marek Los

  Source: Journal of cell science. 2005 Oct 1

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• Cancer-selective therapy of the future: apoptin and its mechanism of action.

  Classical chemotherapy, that specifically targets rapidly proliferating cells, has been in existence for over eighty years and has proven to be fully …

  Authors: Subbareddy Maddika, Francisco J Mendoza, Kristin Hauff, Christina R Zamzow, Ted Paranjothy, Marek Los

  Source: Cancer biology & therapy. 2006 Jan

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• Functional interaction between Chfr and Kif22 controls genomic stability.

  Proper activation of checkpoint during mitotic stress is an important mechanism to prevent genomic instability. Chfr (Check point protein with FHA (Fo…

  Authors: Subbareddy Maddika, Shirley M-H Sy, Junjie Chen

  Source: The Journal of biological chemistry. 2009 May 8

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• Switching Akt: from survival signaling to deadly response.

  Akt, a protein kinase hyperactivated in many tumors, plays a major role in both cell survival and resistance to tumor therapy. A recent study,1 along …

  Authors: Marek Los, Subbareddy Maddika, Bettina Erb, Klaus Schulze-Osthoff

  Source: BioEssays : news and reviews in molecular, cellular and developmental biology. 2009 May

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• Role of BNIP3 in TNF-induced cell death--TNF upregulates BNIP3 expression.

  Tumor necrosis factor alpha (TNF) is a cytokine that induces caspase-dependent (apoptotic) and caspase-independent (necrosis-like) cell death in diffe…

  Authors: Saeid Ghavami, Mehdi Eshraghi, Kamran Kadkhoda, Mark M Mutawe, Subbareddy Maddika, Graham H Bay, Sebastian Wesselborg, Andrew J Halayko, Thomas Klonisch, Marek Los

  Source: Biochimica et biophysica acta. 2009 Mar

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• Stroke, myocardial infarction, acute and chronic inflammatory diseases: caspases and other apoptotic molecules as targets for drug development.

  Mapping of the human and other eukaryotic genomes has provided the pharmacological industry with excellent models for drug discovery. Control of cell …

  Authors: Michael Kreuter, Claus Langer, Claus Kerkhoff, Pallu Reddanna, Anna L Kania, Subbareddy Maddika, Katerina Chlichlia, Truc Nguyen Bui, Marek Los

  Source: Archivum immunologiae et therapiae experimentalis. 2004 May-Jun

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