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Human pregnane X receptor and resistance to chemotherapy in prostate cancer.
Resistance to chemotherapy is a significant barrier to the effective management of prostate cancer. Human pregnane X receptor (hPXR), an orphan nuclea…
Authors: Yakun Chen, Yong Tang, Man-Tzu Wang, Su Zeng, Daotai Nie
Source: Cancer research. 2007 Nov 1
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Clinical features and prognostic factors in patients with bone metastases from hepatocellular carcinoma receiving external beam radiotherapy.
BACKGROUND: The current study was performed to identify clinical features and independent predictors of survival in patients with bone metastases from…
Authors: Jian He, Zhao-Chong Zeng, Zhao-You Tang, Jia Fan, Jian Zhou, Meng-Su Zeng, Jian-Hua Wang, Jing Sun, Bing Chen, Ping Yang,…
Source: Cancer. 2009 Jun 15
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Development of enantioselective polyclonal antibodies to detect styrene oxide protein adducts.
Styrene has been reported to be pneumotoxic and hepatotoxic in humans and animals. Styrene oxide, a major reactive metabolite of styrene, has been fou…
Authors: Shuijie Shen, Fan Zhang, Su Zeng, Ye Tian, Xiaojuan Chai, Shirley Gee, Bruce D Hammock, Jiang Zheng
Source: Analytical chemistry. 2009 Apr 1
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Glucuronidation of flavonoids by recombinant UGT1A3 and UGT1A9.
Flavonoids are highlighted for their potential roles in the prevention of oxidative stress-associated diseases. Their metabolisms in vivo, such as glu…
Authors: Yakun Chen, Shenggu Xie, Shuqing Chen, Su Zeng
Source: Biochemical pharmacology. 2008 Aug 1
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An approach based on liquid chromatography/electrospray ionization-mass spectrometry to detect diol metabolites as biomarkers of exposure to styrene and 1,3-butadiene.
Styrene and 1,3-butadiene are important intermediates used extensively in the plastics industry. They are metabolized mainly through cytochrome P450-m…
Authors: Shuijie Shen, Fan Zhang, Su Zeng, Jiang Zheng
Source: Analytical biochemistry. 2009 Mar 15
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Carboxyl-glucuronidation of mitiglinide by human UDP-glucuronosyltransferases.
Mitiglinide (MGN) is a new potassium channel antagonist for the treatment of type 2 diabetes mellitus. In the present study, a potential metabolic pat…
Authors: Lushan Yu, Sijie Lu, Yongjun Lin, Su Zeng
Source: Biochemical pharmacology. 2007 Jun 1
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Stereoselective transport and uptake of propranolol across human intestinal Caco-2 cell monolayers.
The transport and uptake of individual propranolol (PPL) enantiomers were studied in human intestinal Caco-2 cell monolayers, and a reversed-phase HPL…
Authors: Yi Wang, Jiang Cao, Xiaodan Wang, Su Zeng
Source: Chirality. 2010 Mar
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Enantioselective plasma protein binding of propafenone: mechanism, drug interaction, and species difference.
The interaction of propafenone (PPF) enantiomers with human plasma, human serum albumin (HSA), alpha(1)-acid glycoprotein (AGP), as well as with plasm…
Authors: Yanjun Hong, Yihong Tang, Su Zeng
Source: Chirality. 2009 Jul
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Design, synthesis, and examination of neuron protective properties of alkenylated and amidated dehydro-silybin derivatives.
A series of C7-O- and C20-O-amidated 2,3-dehydrosilybin (DHS) derivatives ((+/-)-1a-f and (+/-)-2), as well as a set of alkenylated DHS analogues ((+/…
Authors: Lei Xiang Yang, Ke Xin Huang, Hai Bo Li, Jing Xu Gong, Feng Wang, Yu Bing Feng, Qiao Feng Tao, Yi Hang Wu, Xiao Kun Li, Xiu Mei Wu,…
Source: Journal of medicinal chemistry. 2009 Dec 10
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An effort to test the embryotoxicity of benzene, toluene, xylene, and formaldehyde to murine embryonic stem cells using airborne exposure technique.
Benzene, toluene, xylene, and formaldehyde are well-known indoor air pollutants, especially after house decoration. They are also common pollutants in…
Authors: Shuijie Shen, Lingmin Yuan, Su Zeng
Source: Inhalation toxicology. 2009 Oct
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