1 to 10 of 51 literature results

• Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease.

  Following recent success in genome-wide association studies, a critical focus of human genetics is to understand how genetic variation at implicated l…

  Authors: Steven A McCarroll, Alan Huett, Petric Kuballa, Shannon D Chilewski, Aimee Landry, Philippe Goyette, Michael C Zody, Jennifer L Hall, Steven R Brant, Judy H Cho,…

  Source: Nature genetics. 2008 Sep

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• Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.

  Ulcerative colitis is a chronic inflammatory disease of the colon that presents as diarrhea and gastrointestinal bleeding. We performed a genome-wide …

  Authors: Mark S Silverberg, Judy H Cho, John D Rioux, Dermot P B McGovern, Jing Wu, Vito Annese, Jean-Paul Achkar, Philippe Goyette, Regan Scott, Wei Xu,…

  Source: Nature genetics. 2009 Feb

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• Genome-wide association identifies multiple ulcerative colitis susceptibility loci.

  Ulcerative colitis is a chronic, relapsing inflammatory condition of the gastrointestinal tract with a complex genetic and environmental etiology. In …

  Authors: Dermot P B McGovern, Agnès Gardet, Leif Törkvist, Philippe Goyette, Jonah Essers, Kent D Taylor, Benjamin M Neale, Rick T H Ong, Caroline Lagacé, Chun Li,…

  Source: Nature genetics. 2010 Mar 14

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• Exposed: the genetic underpinnings of ulcerative colitis relative to Crohn's disease.

  Authors: Steven R Brant

  Source: Gastroenterology. 2009 Feb

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• Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.

  We present a genome-wide association study of ileal Crohn disease and two independent replication studies that identify several new regions of associa…

  Authors: John D Rioux, Ramnik J Xavier, Kent D Taylor, Mark S Silverberg, Philippe Goyette, Alan Huett, Todd Green, Petric Kuballa, M Michael Barmada, Lisa Wu Datta,…

  Source: Nature genetics. 2007 May

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• MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha.

  BACKGROUND & AIMS: Chronic inflammatory bowel diseases such as ulcerative colitis (UC) are associated with differential expression of genes involved i…

  Authors: Feng Wu, Michelle Zikusoka, Anil Trindade, Themistocles Dassopoulos, Mary L Harris, Theodore M Bayless, Steven R Brant, Shukti Chakravarti, John H Kwon

  Source: Gastroenterology. 2008 Nov

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• Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.

  Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combine…

  Authors: Jeffrey C Barrett, Sarah Hansoul, Dan L Nicolae, Judy H Cho, Richard H Duerr, John D Rioux, Steven R Brant, Mark S Silverberg, Kent D Taylor, M Michael Barmada,…

  Source: Nature genetics. 2008 Aug

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• Common variants at five new loci associated with early-onset inflammatory bowel disease.

  The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis are common causes of morbidity in children and young adults in the wester…

  Authors: Marcin Imielinski, Robert N Baldassano, Anne Griffiths, Richard K Russell, Vito Annese, Marla Dubinsky, Subra Kugathasan, Jonathan P Bradfield, Thomas D Walters, Patrick Sleiman,…

  Source: Nature genetics. 2009 Dec

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• Patient trust-in-physician and race are predictors of adherence to medical management in inflammatory bowel disease.

  BACKGROUND: Adherence plays an important role in the therapeutic effectiveness of medical therapy in inflammatory bowel disease (IBD). We assessed whe…

  Authors: Geoffrey C Nguyen, Thomas A LaVeist, Mary L Harris, Lisa W Datta, Theodore M Bayless, Steven R Brant

  Source: Inflammatory bowel diseases. 2009 Aug

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• Corrigendum: Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.

  Authors: Mark S Silverberg, Judy H Cho, John D Rioux, Dermot P B McGovern, Jing Wu, Vito Annese, Jean-Paul Achkar, Philippe Goyette, Regan Scott, Wei Xu,…

  Source: Nature genetics. 2009 Jun

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