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FOXP3: of mice and men.
The immune system has evolved mechanisms to recognize and eliminate threats, as well as to protect against self-destruction. Tolerance to self-antigen…
Authors: Steven F Ziegler
Source: Annual review of immunology. 2006
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Regulatory T cells and inflammation: better late than never.
In this issue of Immunity, Curotto de Lafaille et al. (2008) show that adaptive T regulatory cells control airway inflammation and that it is when the…
Authors: Steven F Ziegler
Source: Immunity. 2008 Jul 18
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TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation.
Dendritic cells (DCs) are professional antigen-presenting cells that have the ability to sense infection and tissue stress, sample and present antigen…
Authors: Yong-Jun Liu, Vasilli Soumelis, Norihiko Watanabe, Tomoki Ito, Yui-Hsi Wang, Rene de Waal Malefyt, Miyuki Omori, Baohua Zhou, Steven F Ziegler
Source: Annual review of immunology. 2007
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Thymic stromal lymphopoietin in normal and pathogenic T cell development and function.
Thymic stromal lymphopoietin, a four helix-bundle cytokine, is expressed mainly by barrier epithelial cells and is a potent activator of several cell …
Authors: Steven F Ziegler, Yong-Jun Liu
Source: Nature immunology. 2006 Jul
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TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function.
T helper cells that produce IL-17 (T(H)17 cells) promote autoimmunity in mice and have been implicated in the pathogenesis of human inflammatory disea…
Authors: Liang Zhou, Jared E Lopes, Mark M W Chong, Ivaylo I Ivanov, Roy Min, Gabriel D Victora, Yuelei Shen, Jianguang Du, Yuri P Rubtsov, Alexander Y Rudensky,…
Source: Nature. 2008 May 8
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Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development.
The cytokine thymic stromal lymphopoietin (TSLP) drives immature B cell development in vitro and may regulate T helper type 2 responses. Here we analy…
Authors: Alexander Astrakhan, Miyuki Omori, Thuc Nguyen, Shirly Becker-Herman, Masanori Iseki, Theingi Aye, Kelly Hudkins, James Dooley, Andrew Farr, Charles E Alpers,…
Source: Nature immunology. 2007 May
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FOXP3 controls regulatory T cell function through cooperation with NFAT.
Antigen stimulation of immune cells activates the transcription factor NFAT, a key regulator of T cell activation and anergy. NFAT forms cooperative c…
Authors: Yongqing Wu, Madhuri Borde, Vigo Heissmeyer, Markus Feuerer, Ariya D Lapan, James C Stroud, Darren L Bates, Liang Guo, Aidong Han, Steven F Ziegler,…
Source: Cell. 2006 Jul 28
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Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice.
The cytokine thymic stromal lymphopoietin (TSLP) has been linked to human allergic inflammatory diseases. We show here that TSLP expression was increa…
Authors: Baohua Zhou, Michael R Comeau, Thibaut De Smedt, H Denny Liggitt, Martin E Dahl, David B Lewis, Dora Gyarmati, Theingi Aye, Daniel J Campbell, Steven F Ziegler
Source: Nature immunology. 2005 Oct
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FOXP3: not just for regulatory T cells anymore.
The forkhead family transcription factor FOXP3 has been shown to be critical for the development and function of CD4+ CD25+ regulatory T cells. Recent…
Authors: Steven F Ziegler
Source: European journal of immunology. 2007 Jan
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CD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice.
Gene transfer of a factor VIII (FVIII) plasmid into hemophilia A (HemA) mice achieved supraphysiologic FVIII expression, but triggered production of h…
Authors: Carol H Miao, Benjamin R Harmeling, Steven F Ziegler, Benjamin C Yen, Troy Torgerson, Liping Chen, Roger J Yau, Baowei Peng, Arthur R Thompson, Hans D Ochs,…
Source: Blood. 2009 Nov 5
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