1 to 10 of 52 literature results

• International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor.

  The nuclear receptors of the NR1H and NR1I subgroups include the constitutive androstane receptor, pregnane X receptor, farnesoid X receptors, liver X…

  Authors: David D Moore, Shigeaki Kato, Wen Xie, David J Mangelsdorf, Daniel R Schmidt, Rui Xiao, Steven A Kliewer

  Source: Pharmacological reviews. 2006 Dec

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• Identification of a hormonal basis for gallbladder filling.

  The cycle of gallbladder filling and emptying controls the flow of bile into the intestine for digestion. Here we show that fibroblast growth factor-1…

  Authors: Mihwa Choi, Antonio Moschetta, Angie L Bookout, Li Peng, Michihisa Umetani, Sam R Holmstrom, Kelly Suino-Powell, H Eric Xu, James A Richardson, Robert D Gerard,…

  Source: Nature medicine. 2006 Nov

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• Anthrax mounts a nuclear attack on glucocorticoid signaling.

  Anthrax causes profound inflammation and systemic shock. A recent study has shown that anthrax lethal toxin represses the transcriptional activity of …

  Authors: Steven A Kliewer

  Source: Trends in pharmacological sciences. 2003 Nov

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• Regulation of cyp3a gene transcription by the pregnane x receptor.

  The pregnane X receptor (PXR) is a promiscuous nuclear receptor that has evolved to protect the body from toxic chemicals. PXR is activated by a struc…

  Authors: Bryan Goodwin, Matthew R Redinbo, Steven A Kliewer

  Source: Annual review of pharmacology and toxicology. 2002

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• Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1.

  The orphan nuclear receptor steroidogenic factor 1 (SF-1) regulates the differentiation and function of endocrine glands. Although SF-1 is constitutiv…

  Authors: Yong Li, Mihwa Choi, Greg Cavey, Jennifer Daugherty, Kelly Suino, Amanda Kovach, Nathan C Bingham, Steven A Kliewer, H Eric Xu

  Source: Molecular cell. 2005 Feb 18

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• Structural basis of human pregnane X receptor activation by the hops constituent colupulone.

  Hops extracts are used to alleviate menopausal symptoms and as an alternative to hormone replacement therapy, but they can produce potentially harmful…

  Authors: Denise G Teotico, Jason J Bischof, Li Peng, Steven A Kliewer, Matthew R Redinbo

  Source: Molecular pharmacology. 2008 Dec

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• Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism.

  OBJECTIVE: Fluxes through mitochondrial pathways are defective in insulin-resistant skeletal muscle, but it is unclear whether similar mitochondrial d…

  Authors: Santhosh Satapati, Tianteng He, Takeshi Inagaki, Matthew Potthoff, Matthew E Merritt, Victoria Esser, David J Mangelsdorf, Steven A Kliewer, Jeffrey D Browning, Shawn C Burgess

  Source: Diabetes. 2008 Aug

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• The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization.

  Constitutive androstane receptor (CAR) induces xenobiotic, bilirubin, and thyroid hormone metabolism as a heterodimer with the retinoid X receptor (RX…

  Authors: Kelly Suino, Li Peng, Ross Reynolds, Yong Li, Ji-Young Cha, Joyce J Repa, Steven A Kliewer, H Eric Xu

  Source: Molecular cell. 2004 Dec 22

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• The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism.

  The nuclear pregnane X receptor (PXR; NR1I2) is an important component of the body's adaptive defense mechanism against toxic substances including for…

  Authors: Steven A Kliewer, Bryan Goodwin, Timothy M Willson

  Source: Endocrine reviews. 2002 Oct

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• Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha.

  Repression of gene transcription by nuclear receptors is mediated by interactions with co-repressor proteins such as SMRT and N-CoR, which in turn rec…

  Authors: H Eric Xu, Thomas B Stanley, Valerie G Montana, Millard H Lambert, Barry G Shearer, Jeffery E Cobb, David D McKee, Cristin M Galardi, Kelli D Plunket, Robert T Nolte,…

  Source: Nature. 2002 Feb 14

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