1 to 10 of 76 literature results

• Platelet activation by extracellular matrix proteins in haemostasis and thrombosis.

  The prevention of excessive blood loss to avoid fatal haemorrhage is a pivotal process for all organisms possessing a circulatory system. Increased ci…

  Authors: Steve P Watson

  Source: Current pharmaceutical design. 2009

  View Full Text

• Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization, secondary mediators, and Rac.

  The C-type lectin-like receptor 2 (CLEC-2) activates platelets through Src and Syk tyrosine kinases via a single cytoplasmic YxxL motif known as a hem…

  Authors: Alice Y Pollitt, Beata Grygielska, Bertrand Leblond, Laurent Désiré, Johannes A Eble, Steve P Watson

  Source: Blood. 2010 Apr 8

  View Full Text

• Critical role of Src-Syk-PLC{gamma}2 signalling in megakaryocyte migration and thrombopoiesis.

  Migration of megakaryocytes (MKs) from the proliferative osteoblastic niche to the capillary-rich vascular niche is essential for proplatelet formatio…

  Authors: Alexandra Mazharian, Steve G Thomas, Tarvinder S Dhanjal, Christopher D Buckley, Steve P Watson

  Source: Blood. 2010 May 10

  View Full Text

• CLEC-2 activates Syk through dimerization.

  The C-type lectin receptor CLEC-2 activates platelets through Src and Syk tyrosine kinases, leading to tyrosine phosphorylation of downstream adapter …

  Authors: Craig E Hughes, Alice Y Pollitt, Jun Mori, Johannes A Eble, Michael G Tomlinson, John H Hartwig, Christopher A O'Callaghan, Klaus Fütterer, Steve P Watson

  Source: Blood. 2010 Apr 8

  View Full Text

• Regulation of proplatelet formation and platelet release by integrin alpha IIb beta3.

  Mature megakaryocytes form structures called proplatelets that serve as conduits for platelet packaging and release at vascular sinusoids. Since the m…

  Authors: Mark K Larson, Steve P Watson

  Source: Blood. 2006 Sep 1

  View Full Text

• A novel thromboxane A2 receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis.

  We investigated the cause of mild mucocutaneous bleeding in a 14-year-old male patient (P1). Platelet aggregation and ATP secretion induced by arachid…

  Authors: Andrew D Mumford, Ban B Dawood, Martina E Daly, Sherina L Murden, Michael D Williams, Majd B Protty, Jennifer C Spalton, Mark Wheatley, Stuart J Mundell, Steve P Watson

  Source: Blood. 2010 Jan 14

  View Full Text

• The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis.

  Platelets play a fundamental role in hemostasis and thrombosis. They are also involved in pathologic conditions resulting from blocked blood vessels, …

  Authors: Yotis A Senis, Michael G Tomlinson, Stuart Ellison, Alexandra Mazharian, Jenson Lim, Yan Zhao, Kristin N Kornerup, Jocelyn M Auger, Steve G Thomas, Tarvinder Dhanjal,…

  Source: Blood. 2009 May 14

  View Free Full Text

• JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia.

  The JAK2 V617F mutation is found in most patients with a myeloproliferative neoplasm (MPN) and is sufficient to produce a myeloproliferative phenotype…

  Authors: Juan Li, Dominik Spensberger, Jong Sook Ahn, Shubha Anand, Philip A Beer, Cedric Ghevaert, Edwin Chen, Ariel Forrai, Linda M Scott, Rita Ferreira,…

  Source: Blood. 2010 May 20

  View Full Text

• Critical role for ERK1/2 in bone marrow and fetal liver-derived primary megakaryocyte differentiation, motility, and proplatelet formation.

  OBJECTIVE: Megakaryopoiesis and platelet formation is a multistep process through which hematopoietic progenitor cells develop into mature megakaryocy…

  Authors: Alexandra Mazharian, Steve P Watson, Sonia Séverin

  Source: Experimental hematology. 2009 Oct

  View Full Text

• Dual role of collagen in factor XII-dependent thrombus formation.

  In vivo mouse models have indicated that the intrinsic coagulation pathway, initiated by factor XII, contributes to thrombus formation in response to …

  Authors: Paola E J van der Meijden, Imke C A Munnix, Jocelyn M Auger, José W P Govers-Riemslag, Judith M E M Cosemans, Marijke J E Kuijpers, Henri M Spronk, Steve P Watson, Thomas Renné, Johan W M Heemskerk

  Source: Blood. 2009 Jul 23

  View Full Text