1 to 10 of 40 literature results

• PKB/Akt modulates TGF-beta signalling through a direct interaction with Smad3.

  Transforming growth factor beta (TGF-beta) has a major role in cell proliferation, differentiation and apoptosis in many cell types. Integration of th…

  Authors: Ingrid Remy, Annie Montmarquette, Stephen W Michnick

  Source: Nature cell biology. 2004 Apr

  View Full Text

• Hereditary inclusion body myopathy-linked p97/VCP mutations in the NH2 domain and the D1 ring modulate p97/VCP ATPase activity and D2 ring conformation.

  Hereditary inclusion body myopathy associated with early-onset Paget disease of bone and frontotemporal dementia (hIBMPFTD) is a degenerative disorder…

  Authors: Dalia Halawani, Andréa C LeBlanc, Isabelle Rouiller, Stephen W Michnick, Marc J Servant, Martin Latterich

  Source: Molecular and cellular biology. 2009 Aug

  View Free Full Text

• A luxRury of synthetic signals.

  Authors: Stephen W Michnick

  Source: Nature biotechnology. 2006 Jun

  View Full Text

• Beta-lactamase protein fragment complementation assays as in vivo and in vitro sensors of protein protein interactions.

  We have previously described a strategy for detecting protein protein interactions based on protein interaction assisted folding of rationally designe…

  Authors: André Galarneau, Martin Primeau, Louis-Eric Trudeau, Stephen W Michnick

  Source: Nature biotechnology. 2002 Jun

  View Full Text

• Multiple tryptophan probes reveal that ubiquitin folds via a late misfolded intermediate.

  Much of our understanding of protein folding mechanisms is derived from experiments using intrinsic fluorescence of natural or genetically inserted tr…

  Authors: Alexis Vallée-Bélisle, Stephen W Michnick

  Source: Journal of molecular biology. 2007 Nov 30

  View Full Text

• Proteomics in living cells.

  The study of protein dynamics in vivo is central to understanding the chemical machinery that makes up the process of life: in determining how, when, …

  Authors: Stephen W Michnick

  Source: Drug discovery today. 2004 Mar 15

  View Full Text

• Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt.

  The serine/threonine kinase protein kinase B (PKB)/Akt plays a central role in many cellular processes, including cell growth, glucose metabolism, and…

  Authors: Ingrid Remy, Stephen W Michnick

  Source: Molecular and cellular biology. 2004 Feb

  View Free Full Text

• Protein fragment complementation strategies for biochemical network mapping.

  The organization of biochemical networks that make up the living cell can be defined by studying the dynamics of protein-protein interactions. To this…

  Authors: Stephen W Michnick

  Source: Current opinion in biotechnology. 2003 Dec

  View Full Text

• Convergent preparation and photophysical characterization of dimaleimide dansyl fluorogens: elucidation of the maleimide fluorescence quenching mechanism.

  Dimaleimide fluorogens are being developed for application to fluorescent protein labeling. In this method, fluorophores bearing two maleimide quenchi…

  Authors: Julia Guy, Karine Caron, Stéphane Dufresne, Stephen W Michnick, W G Skene, Jeffrey W Keillor

  Source: Journal of the American Chemical Society. 2007 Oct 3

  View Full Text

• Application of protein-fragment complementation assays in cell biology.

  We have developed a general experimental strategy that enables the quantitative detection of dynamic protein-protein interactions in intact living cel…

  Authors: Ingrid Remy, Stephen W Michnick

  Source: BioTechniques. 2007 Feb

  View Full Text