1 to 7 of 7 literature results

• Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.

  Phosphoinositide 3-kinases (PI3Ks) signal downstream of multiple cell-surface receptor types. Class IA PI3K isoforms couple to tyrosine kinases and co…

  Authors: Mariona Graupera, Julie Guillermet-Guibert, Lazaros C Foukas, Li-Kun Phng, Robert J Cain, Ashreena Salpekar, Wayne Pearce, Stephen Meek, Jaime Millan, Pedro R Cutillas,…

  Source: Nature. 2008 May 29

  View Full Text

• Capture of authentic embryonic stem cells from rat blastocysts.

  Embryonic stem (ES) cells have been available from inbred mice since 1981 but have not been validated for other rodents. Failure to establish ES cells…

  Authors: Mia Buehr, Stephen Meek, Kate Blair, Jian Yang, Janice Ure, Jose Silva, Renee McLay, John Hall, Qi-Long Ying, Austin Smith

  Source: Cell. 2008 Dec 26

  View Full Text

• Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation.

  The eight catalytic subunits of the mammalian phosphoinositide-3-OH kinase (PI(3)K) family form the backbone of an evolutionarily conserved signalling…

  Authors: Lazaros C Foukas, Marc Claret, Wayne Pearce, Klaus Okkenhaug, Stephen Meek, Emma Peskett, Sara Sancho, Andrew J H Smith, Dominic J Withers, Bart Vanhaesebroeck

  Source: Nature. 2006 May 18

  View Full Text

• Neurofascins are required to establish axonal domains for saltatory conduction.

  Voltage-gated sodium channels are concentrated in myelinated nerves at the nodes of Ranvier flanked by paranodal axoglial junctions. Establishment of …

  Authors: Diane L Sherman, Steven Tait, Shona Melrose, Richard Johnson, Barbara Zonta, Felipe A Court, Wendy B Macklin, Stephen Meek, Andrew J H Smith, David F Cottrell,…

  Source: Neuron. 2005 Dec 8

  View Full Text

• Targeted homozygous deletion of M-band titin in cardiomyocytes prevents sarcomere formation.

  Titin, a multifunctional protein that stretches from the Z-disk to the M-band in heart and skeletal muscle, contains a kinase domain, phosphorylation …

  Authors: Hanny Musa, Stephen Meek, Mathias Gautel, Dianna Peddie, Andrew J H Smith, Michelle Peckham

  Source: Journal of cell science. 2006 Oct 15

  View Full Text

• The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells.

  We have addressed the role of the inducible costimulator (ICOS) in the development of T cell help for B cells and in the generation, survival and reac…

  Authors: Simmi Mahajan, Ana Cervera, Megan MacLeod, Simon Fillatreau, Georgia Perona-Wright, Stephen Meek, Andrew Smith, Andrew MacDonald, David Gray

  Source: European journal of immunology. 2007 Jul

  View Full Text

• The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.

  The p110 isoforms of phosphoinositide 3-kinase (PI3K) are acutely regulated by extracellular stimuli. The class IA PI3K catalytic subunits (p110alpha,…

  Authors: Julie Guillermet-Guibert, Katja Bjorklof, Ashreena Salpekar, Cristiano Gonella, Faruk Ramadani, Antonio Bilancio, Stephen Meek, Andrew J H Smith, Klaus Okkenhaug, Bart Vanhaesebroeck

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2008 Jun 17

  View Free Full Text