1 to 10 of 49 literature results

• MyoD and E-protein heterodimers switch rhabdomyosarcoma cells from an arrested myoblast phase to a differentiated state.

  Rhabdomyosarcomas are characterized by expression of myogenic specification genes, such as MyoD and/or Myf5, and some muscle structural genes in a pop…

  Authors: Zhihong Yang, Kyle L MacQuarrie, Erwin Analau, Ashlee E Tyler, F Jeffery Dilworth, Yi Cao, Scott J Diede, Stephen J Tapscott

  Source: Genes & development. 2009 Mar 15

  View Free Full Text

• Widespread and nonrandom distribution of DNA palindromes in cancer cells provides a structural platform for subsequent gene amplification.

  Breakage-fusion-bridge cycles contribute to chromosome instability and generate large DNA palindromes that facilitate gene amplification in human canc…

  Authors: Hisashi Tanaka, Donald A Bergstrom, Meng-Chao Yao, Stephen J Tapscott

  Source: Nature genetics. 2005 Mar

  View Full Text

• Emerging parallels in the generation and regeneration of skeletal muscle.

  Previously, skeletal muscle regeneration appeared to be very different from embryonic specification of muscle, but in this issue of Cell, Polesskaya e…

  Authors: Lauren Snider, Stephen J Tapscott

  Source: Cell. 2003 Jun 27

  View Full Text

• Antisense transcription and heterochromatin at the DM1 CTG repeats are constrained by CTCF.

  Prior studies of the DM1 locus have shown that the CTG repeats are a component of a CTCF-dependent insulator element and that repeat expansion results…

  Authors: Diane H Cho, Cortlandt P Thienes, Sarah E Mahoney, Erwin Analau, Galina N Filippova, Stephen J Tapscott

  Source: Molecular cell. 2005 Nov 11

  View Full Text

• Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice.

  Disruption of cell polarity is seen in many cancers; however, it is generally considered a late event in tumor progression. Lethal giant larvae (Lgl) …

  Authors: Olga Klezovitch, Tania E Fernandez, Stephen J Tapscott, Valeri Vasioukhin

  Source: Genes & development. 2004 Mar 1

  View Free Full Text

• BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect.

  The mechanisms of retinoid activity in tumors remain largely unknown. Here we establish that retinoids cause extensive apoptosis of medulloblastoma ce…

  Authors: Andrew R Hallahan, Joel I Pritchard, Roshantha A S Chandraratna, Richard G Ellenbogen, J Russel Geyer, Ryan P Overland, Andrew D Strand, Stephen J Tapscott, James M Olson

  Source: Nature medicine. 2003 Aug

  View Full Text

• Regulation of thalamocortical patterning and synaptic maturation by NeuroD2.

  During cortical development, both activity-dependent and genetically determined mechanisms are required to establish proper neuronal connectivity. Whi…

  Authors: Gulayse Ince-Dunn, Benjamin J Hall, Shu-Ching Hu, Beth Ripley, Richard L Huganir, James M Olson, Stephen J Tapscott, Anirvan Ghosh

  Source: Neuron. 2006 Mar 2

  View Full Text

• Pbx marks genes for activation by MyoD indicating a role for a homeodomain protein in establishing myogenic potential.

  Skeletal muscle differentiation is initiated by the transcription factor MyoD, which binds directly to the regulatory regions of genes expressed durin…

  Authors: Charlotte A Berkes, Donald A Bergstrom, Bennett H Penn, Karen J Seaver, Paul S Knoepfler, Stephen J Tapscott

  Source: Molecular cell. 2004 May 21

  View Full Text

• Cell-lineage regulated myogenesis for dystrophin replacement: a novel therapeutic approach for treatment of muscular dystrophy.

  Duchenne muscular dystrophy (DMD) is characterized in skeletal muscle by cycles of myofiber necrosis and regeneration leading to loss of muscle fibers…

  Authors: En Kimura, Jay J Han, Sheng Li, Brent Fall, Jennifer Ra, Miki Haraguchi, Stephen J Tapscott, Jeffrey S Chamberlain

  Source: Human molecular genetics. 2008 Aug 15

  View Free Full Text

• XIC is required for Siamois activity and dorsoanterior development.

  Siamois is the transcriptional mediator of the dorsal Wnt signaling pathway and is necessary for formation of the Spemann organizer and dorsoanterior …

  Authors: Lauren Snider, Stephen J Tapscott

  Source: Molecular and cellular biology. 2005 Jun

  View Free Full Text